ID M3TR10_ENTH1 Unreviewed; 535 AA. AC M3TR10; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 24-JAN-2024, entry version 28. DE SubName: Full=Crooked neck protein, putative {ECO:0000313|EMBL:EMH78038.1}; GN ORFNames=EHI8A_192450 {ECO:0000313|EMBL:EMH78038.1}; OS Entamoeba histolytica HM-1:IMSS-B. OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae; OC Entamoeba. OX NCBI_TaxID=885319 {ECO:0000313|EMBL:EMH78038.1, ECO:0000313|Proteomes:UP000030781}; RN [1] {ECO:0000313|EMBL:EMH78038.1, ECO:0000313|Proteomes:UP000030781} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HM3:IMSS-B {ECO:0000313|Proteomes:UP000030781}; RA Hannick L., Zafar N., Lorenzi H., Ali I.A., Petri W.P., Caler E.; RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression. CC Required for the spliceosome assembly and initiation of the DNA CC replication. {ECO:0000256|ARBA:ARBA00037040}. CC -!- SUBUNIT: Associated with the spliceosome. CC {ECO:0000256|ARBA:ARBA00011524}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the crooked-neck family. CC {ECO:0000256|ARBA:ARBA00008644}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KB609845; EMH78038.1; -; Genomic_DNA. DR AlphaFoldDB; M3TR10; -. DR EnsemblProtists; EMH78038; EMH78038; EHI8A_192450. DR VEuPathDB; AmoebaDB:EHI8A_192450; -. DR Proteomes; UP000030781; Unassembled WGS sequence. DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro. DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2. DR InterPro; IPR003107; HAT. DR InterPro; IPR045075; Syf1-like. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR InterPro; IPR019734; TPR_repeat. DR PANTHER; PTHR11246:SF3; CROOKED NECK-LIKE PROTEIN 1; 1. DR PANTHER; PTHR11246; PRE-MRNA SPLICING FACTOR; 1. DR Pfam; PF14559; TPR_19; 1. DR SMART; SM00386; HAT; 11. DR SUPFAM; SSF48452; TPR-like; 3. DR PROSITE; PS50005; TPR; 1. PE 3: Inferred from homology; KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}. FT REPEAT 422..455 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" SQ SEQUENCE 535 AA; 65784 MW; 2EE160605409F83A CRC64; MNKVKDIYIH LNFMNNERLK QRKTLKCLVL TKLLQLYYVI VGGKICCFYH IQLKELEKEV MIMSNKPIIK NREFAEIQIT AEQLIREARD NQTPSYTRPK MTIHDEEELQ AYRLTKRKEF EQGVTKERQN PKRWTRYAFW EEEQGEYVRA RSIFERALEQ DYTIADTWMK YVDFELRNNQ VNKARNILER ATSLLPMVYK LWFKYVRLEE TVENFDHCKE VFEKWMTFKP GEYPWLAYIK FEIRIGEIKV AKELFEQANQ QLHCEEIYKE WVEFEKRFGT VESTRELFNK MAKDIEVCQN SYYQMFAEFE LSQGEIERAR QIYLFGIDHS KEENKRILLN NYVKFEKING EMKDVDNAIW KKRRFEYEQK IQENPFDYDT WYDYIQMEMN EIESEETTTM LYERIISQTP QEITKEKWTR YIEFWVLYAR YEEKLQHYEN AFDIFSRTIK IIPHKYFTFK KVWRAYANYA RRRKNIPLVR KIYGAAIGWC HKDDIFKDYI EFETENGEQE RIHKIQAKWN EFKPKEIKQE EVNNE //