ID M1X892_PIPNO Unreviewed; 229 AA. AC M1X892; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 03-AUG-2022, entry version 35. DE RecName: Full=Cytochrome c oxidase subunit 1 {ECO:0000256|ARBA:ARBA00015947}; DE AltName: Full=Cytochrome c oxidase polypeptide I {ECO:0000256|ARBA:ARBA00032715}; DE Flags: Fragment; GN Name=COI {ECO:0000313|EMBL:CCN27095.1}; OS Pipiza noctiluca (Hoverfly) (Musca noctiluca). OG Mitochondrion {ECO:0000313|EMBL:CCN27095.1}. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Syrphoidea; OC Syrphidae; Syrphinae; Pipizini; Pipiza. OX NCBI_TaxID=1162231 {ECO:0000313|EMBL:CCN27095.1}; RN [1] {ECO:0000313|EMBL:CCN27095.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FSUNS:J003 {ECO:0000313|EMBL:CCN27095.1}; RA Vujic A., Stahls G., Acanski J., Bartsch H., Bygebjerg R., Stefanovic A.; RT "Systematics of Pipizini and taxonomy of European Pipiza Fall.n: molecular RT and morphological evidence (Diptera, Syrphidae)."; RL Zool. Scr. 42:288-305(2013). CC -!- CATALYTIC ACTIVITY: CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)- CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436, CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, CC ChEBI:CHEBI:29034; EC=7.1.1.9; CC Evidence={ECO:0000256|ARBA:ARBA00029331}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11437; CC Evidence={ECO:0000256|ARBA:ARBA00029331}; CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; CC Evidence={ECO:0000256|ARBA:ARBA00001971}; CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC {ECO:0000256|ARBA:ARBA00004673}. CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a CC multisubunit enzyme composed of a catalytic core of 3 subunits and CC several supernumerary subunits. The complex exists as a monomer or a CC dimer and forms supercomplexes (SCs) in the inner mitochondrial CC membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 CC complex, complex III, CIII). {ECO:0000256|ARBA:ARBA00011164}. CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC {ECO:0000256|ARBA:ARBA00009578}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HF542967; CCN27095.1; -; Genomic_DNA. DR UniPathway; UPA00705; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway. DR Gene3D; 1.20.210.10; -; 1. DR InterPro; IPR023616; Cyt_c_oxase-like_su1_dom. DR InterPro; IPR036927; Cyt_c_oxase-like_su1_sf. DR InterPro; IPR000883; Cyt_C_Oxase_1. DR PANTHER; PTHR10422; PTHR10422; 1. DR Pfam; PF00115; COX1; 1. DR SUPFAM; SSF81442; SSF81442; 1. DR PROSITE; PS50855; COX1; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000313|EMBL:CCN27095.1}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 12..32 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 44..69 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 81..100 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 120..141 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 153..171 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 191..214 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..229 FT /note="COX1" FT /evidence="ECO:0000259|PROSITE:PS50855" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:CCN27095.1" FT NON_TER 229 FT /evidence="ECO:0000313|EMBL:CCN27095.1" SQ SEQUENCE 229 AA; 25908 MW; 8A1DA0E74477B3C3 CRC64; QECGKXETFG SLGMIYAMLS IGILGFIVWA HHMFTIGMDV DTRAYFTSAT MVIAIPTGIK VFSWMATIYG TQLIYSPTMM WALGFVFLFT IGGLTGVVLA NSSIDLILHD TYYVVAHFHY VLSMGAVFAI MTGFIHWYPL FTGLTLNTKW LKTQFTVMFI GVNLTFFPQH FLGLAGMPRR YSDYPDAYTT WNIMSTIGST ISLLAIIMFM IIIWKSMIKQ RQVIYAIQL //