ID M1V8F4_CYAM1 Unreviewed; 575 AA. AC M1V8F4; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 27-MAR-2024, entry version 43. DE RecName: Full=Major facilitator superfamily domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040619}; GN ORFNames=CYME_CMK236C {ECO:0000313|EMBL:BAM80589.1}; OS Cyanidioschyzon merolae (strain NIES-3377 / 10D) (Unicellular red alga). OC Eukaryota; Rhodophyta; Bangiophyceae; Cyanidiales; Cyanidiaceae; OC Cyanidioschyzon. OX NCBI_TaxID=280699 {ECO:0000313|EMBL:BAM80589.1, ECO:0000313|Proteomes:UP000007014}; RN [1] {ECO:0000313|EMBL:BAM80589.1, ECO:0000313|Proteomes:UP000007014} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=10D {ECO:0000313|EMBL:BAM80589.1, RC ECO:0000313|Proteomes:UP000007014}; RX PubMed=15071595; DOI=10.1038/nature02398; RA Matsuzaki M., Misumi O., Shin-i T., Maruyama S., Takahara M., RA Miyagishima S., Mori T., Nishida K., Yagisawa F., Nishida K., Yoshida Y., RA Nishimura Y., Nakao S., Kobayashi T., Momoyama Y., Higashiyama T., RA Minoda A., Sano M., Nomoto H., Oishi K., Hayashi H., Ohta F., Nishizaka S., RA Haga S., Miura S., Morishita T., Kabeya Y., Terasawa K., Suzuki Y., RA Ishii Y., Asakawa S., Takano H., Ohta N., Kuroiwa H., Tanaka K., RA Shimizu N., Sugano S., Sato N., Nozaki H., Ogasawara N., Kohara Y., RA Kuroiwa T.; RT "Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon RT merolae 10D."; RL Nature 428:653-657(2004). RN [2] {ECO:0000313|EMBL:BAM80589.1, ECO:0000313|Proteomes:UP000007014} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=10D {ECO:0000313|EMBL:BAM80589.1, RC ECO:0000313|Proteomes:UP000007014}; RX PubMed=17623057; DOI=10.1186/1741-7007-5-28; RA Nozaki H., Takano H., Misumi O., Terasawa K., Matsuzaki M., Maruyama S., RA Nishida K., Yagisawa F., Yoshida Y., Fujiwara T., Takio S., Tamura K., RA Chung S.J., Nakamura S., Kuroiwa H., Tanaka K., Sato N., Kuroiwa T.; RT "A 100%-complete sequence reveals unusually simple genomic features in the RT hot-spring red alga Cyanidioschyzon merolae."; RL BMC Biol. 5:28-28(2007). CC -!- SUBCELLULAR LOCATION: Lysosome membrane CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004155}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP006493; BAM80589.1; -; Genomic_DNA. DR RefSeq; XP_005536625.1; XM_005536568.1. DR AlphaFoldDB; M1V8F4; -. DR TCDB; 2.A.1.53.4; the major facilitator superfamily (mfs). DR EnsemblPlants; CMK236CT; CMK236CT; CMK236C. DR GeneID; 16994252; -. DR Gramene; CMK236CT; CMK236CT; CMK236C. DR KEGG; cme:CYME_CMK236C; -. DR eggNOG; KOG4686; Eukaryota. DR HOGENOM; CLU_024694_1_1_1; -. DR OMA; YYSAIFP; -. DR OrthoDB; 1387029at2759; -. DR Proteomes; UP000007014; Chromosome 11. DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro. DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2. DR InterPro; IPR011701; MFS. DR InterPro; IPR020846; MFS_dom. DR InterPro; IPR036259; MFS_trans_sf. DR PANTHER; PTHR23512; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1; 1. DR PANTHER; PTHR23512:SF3; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1; 1. DR Pfam; PF07690; MFS_1; 1. DR SUPFAM; SSF103473; MFS general substrate transporter; 1. DR PROSITE; PS50850; MFS; 1. PE 4: Predicted; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007014}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 32..49 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 70..92 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 98..120 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 132..153 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 192..213 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 260..287 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 299..317 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 323..344 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 359..380 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 386..411 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 423..443 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 31..449 FT /note="Major facilitator superfamily (MFS) profile" FT /evidence="ECO:0000259|PROSITE:PS50850" FT REGION 226..245 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 546..575 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 575 AA; 61513 MW; BEA65FE0E83BD11B CRC64; MEDDYGSIES AKPQQDASSA QAAIEASGST RALILAAACL LTFGSYFCYD TPSALVITLR EKLQLTGFQY NVLFSIYSWP NVVLVFIGGL VIDTYGSRRA SLALATLVLV GQVVMLIGVL QHRYWLLLSG RFIFGMGGES LGVCQSIIVS RWFAGHELAT AFGLSLTVSR IGSILSFMLL PVVDQVAGIV SAFAVGVIIC ALSICAALVY ASIELSVEHK RAEGAAALQP TKTRTRAPAG ERSPRSRRSS LLQVARCLDL SFWLCAGISM VSYALVFSFI AIGSDLLHQA FGTSRERGSL LVSLVYDFSM VLAPLLGRLF DAVGLRGIFV LVSCTLNLLS FALLEHTRTS AWQPVPRPVY GMICMGVAFS GLSSSVWPSM TVISPVWALG AALGIAQALQ NLGTSLMSIY VGHVVDAFGY EAVLSRFVLI ACIAVLLALW WNIDDWRYRD GRVNRSAAAA EAAAAAAMEL PVAAGTPQGA AVAYVPLYVP VYVMVSPEAI QSVRRACYQK LGESEVGIRR RDLYAQLGIA HPAVVRKAAE TGAQLPSPDA YHARVFRPER PTEAAGSASS SQSTN //