ID M1L269_9HIV1 Unreviewed; 853 AA. AC M1L269; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 19-FEB-2014, entry version 7. DE RecName: Full=Envelope glycoprotein gp160; GN Name=env; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=2011.ANHUI.WH69; RX PubMed=23372706; DOI=10.1371/journal.pone.0054322; RA Wu J., Meng Z., Xu J., Lei Y., Jin L., Zhong P., Han R., Su B.; RT "New Emerging Recombinant HIV-1 Strains and Close Transmission Linkage RT of HIV-1 Strains in the Chinese MSM Population Indicate a New Epidemic RT Risk."; RL PLoS ONE 8:E54322-E54322(2013). CC -!- FUNCTION: The envelope glyprotein gp160 precursor down-modulates CC cell surface CD4 antigen by interacting with it in the endoplasmic CC reticulum and blocking its transport to the cell surface (By CC similarity). CC -!- FUNCTION: The gp120-gp41 heterodimer allows rapid transcytosis of CC the virus through CD4 negative cells such as simple epithelial CC monolayers of the intestinal, rectal and endocervical epithelial CC barriers. Both gp120 and gp41 specifically recognize CC glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo- CC galactosyl-ceramide (GalS) present in the lipid rafts structures CC of epithelial cells. Binding to these alternative receptors allows CC the rapid transcytosis of the virus through the epithelial cells. CC This transcytotic vesicle-mediated transport of virions from the CC apical side to the basolateral side of the epithelial cells does CC not involve infection of the cells themselves (By similarity). CC -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass type I membrane CC protein. Host cell membrane; Single-pass type I membrane protein. CC Host endosome membrane; Single-pass type I membrane protein (By CC similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC183781; AGF34672.1; -; Genomic_RNA. DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR Gene3D; 2.170.40.20; -; 2. DR InterPro; IPR000777; HIV1_GP160. DR InterPro; IPR000328; Retroviral_envelope_protein. DR Pfam; PF00516; GP120; 1. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; SSF56502; 2. PE 3: Inferred from homology; KW AIDS; Apoptosis; Cleavage on pair of basic residues; Disulfide bond; KW Fusion of virus membrane with host membrane; Host cell membrane; KW Host endosome; Host membrane; Host-virus interaction; Membrane; KW Transmembrane; Transmembrane helix; Viral attachment to host cell; KW Viral envelope protein; Viral immunoevasion; KW Viral penetration into host cytoplasm; Virion; KW Virus entry into host cell. FT UNSURE 272 272 D or N. SQ SEQUENCE 853 AA; 96371 MW; 08A2E3C1825E45EC CRC64; MRVTGIKKNW PLWKWGTMLL GMLMICSAEG NLWVTVYYGV PVWKEATTTL FCASDAKAYN AEAHNVWATH ACVPTDPDPQ EVVLENVTEN FNMWKNEMVN QMHEDVISLW DQSLKPCVKL TPLCVTLNCT NVTSNSNSVN NNSSLENTQE MKNCSFNTTT VVRDKKQQVY ALFYRLDIVP LTNSSEYRLI NCNTSAITQA CPKVSFDPIP IHYCTPAGYA LLKCNDERFN GTGPCHNVSS VQCTHGIKPV VSTQLLLNGS LAEKEIIVRS EDLTNNAKTI IVQLNKSVEI VCIRPGNNTR KSIRIGPGQT FYATGEIIGD IRQAHCNISG KDWEETLRNV SKKLAEHFQN KTIQFASSSG GDLEITTHSF NCRGEFFYCN TSGLFNKTYM HNDTLNSTEN WPXITIPCRI KQIINMWQEV GRAMYAPPIA GNITCKSNIT GLLLVRDGGA GSNDTEIFRP GGGDMRDNWR SELYKYKVVE IKPLGVAPTD AKRRVVEREK RAVGIGAVFL GFLGVAGSTM GAASLTLTVQ ARQLLSGIVQ QQSNLLRAIE AQQHMLQLTV WGIKQLQTRV LAIERYLKDQ QLLGIWGCSG KLICTTAVPW NSSWSNKSQK EIWDNMTWMQ WDKEISNYTD TIYRLLEVSQ NQQERNEKDL LALDSWKNLW NWFDITNWLW YIKIFIMIVG GLIGLRIIFA VLSIVKRVRE GYSPLSFQTP SHHQREPDRP EGIEEGGGEQ GRDRSVRLVS GFLAIVWDDL RSLCLFSYHR LRDFILIATR TVELLGHSSL KGLRRGWEGL KYLGNLLLYW GQELKISAIS LIDATAIATA GWTDRVIEAA QRAWLALLHI PRRIRQGFER ALV //