ID M1L269_9HIV1 Unreviewed; 853 AA. AC M1L269; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 18-JUL-2018, entry version 41. DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|RuleBase:RU363095}; DE Contains: DE RecName: Full=Surface protein gp120 {ECO:0000256|RuleBase:RU363095}; DE Short=SU {ECO:0000256|RuleBase:RU363095}; DE AltName: Full=Glycoprotein 120 {ECO:0000256|RuleBase:RU363095}; DE Short=gp120 {ECO:0000256|RuleBase:RU363095}; DE Contains: DE RecName: Full=Transmembrane protein gp41 {ECO:0000256|RuleBase:RU363095}; DE Short=TM {ECO:0000256|RuleBase:RU363095}; GN Name=env {ECO:0000313|EMBL:AGF34672.1}; OS Human immunodeficiency virus 1. OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AGF34672.1, ECO:0000313|Proteomes:UP000106273}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AGF34672.1, ECO:0000313|Proteomes:UP000106273} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2011.ANHUI.WH69 {ECO:0000313|EMBL:AGF34672.1}; RX PubMed=23372706; DOI=10.1371/journal.pone.0054322; RA Wu J., Meng Z., Xu J., Lei Y., Jin L., Zhong P., Han R., Su B.; RT "New Emerging Recombinant HIV-1 Strains and Close Transmission Linkage RT of HIV-1 Strains in the Chinese MSM Population Indicate a New Epidemic RT Risk."; RL PLoS ONE 8:E54322-E54322(2013). CC -!- SUBUNIT: The mature envelope protein (Env) consists of a CC homotrimer of non-covalently associated gp120-gp41 heterodimers. CC The resulting complex protrudes from the virus surface as a spike. CC {ECO:0000256|RuleBase:RU363095}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS01060237}; Peripheral membrane protein CC {ECO:0000256|SAAS:SAAS01060237}. Host cell membrane CC {ECO:0000256|SAAS:SAAS01060091}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS01060091}. Host endosome membrane CC {ECO:0000256|SAAS:SAAS01060316}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS01060316}. Virion membrane CC {ECO:0000256|SAAS:SAAS00796993}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00796993}. CC -!- DOMAIN: The 17 amino acids long immunosuppressive region is CC present in many retroviral envelope proteins. Synthetic peptides CC derived from this relatively conserved sequence inhibit immune CC function in vitro and in vivo. {ECO:0000256|RuleBase:RU363095}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|RuleBase:RU363095}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC183781; AGF34672.1; -; Genomic_RNA. DR Proteomes; UP000106273; Genome. DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule. DR GO; GO:0090527; P:actin filament reorganization; IEA:UniProtKB-UniRule. DR GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-UniRule. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-UniRule. DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-UniRule. DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:1903905; P:positive regulation of establishment of T cell polarity; IEA:UniProtKB-UniRule. DR GO; GO:1903908; P:positive regulation of plasma membrane raft polarization; IEA:UniProtKB-UniRule. DR GO; GO:1903911; P:positive regulation of receptor clustering; IEA:UniProtKB-UniRule. DR GO; GO:0019082; P:viral protein processing; IEA:UniProtKB-UniRule. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule. DR CDD; cd09909; HIV-1-like_HR1-HR2; 1. DR Gene3D; 2.170.40.20; -; 2. DR HAMAP; MF_04083; HIV_ENV; 1. DR InterPro; IPR036377; Gp120_core_sf. DR InterPro; IPR037527; Gp160. DR InterPro; IPR000328; GP41-like. DR InterPro; IPR000777; HIV1_Gp120. DR Pfam; PF00516; GP120; 2. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; SSF56502; 2. PE 3: Inferred from homology; KW Apoptosis {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS01060203}; KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU363095}; KW Complete proteome {ECO:0000313|Proteomes:UP000106273}; KW Disulfide bond {ECO:0000256|SAAS:SAAS01050261}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|RuleBase:RU363095, ECO:0000256|SAAS:SAAS01050351}; KW Host cell membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS01060118}; KW Host endosome {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS01060155}; KW Host membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS01060308}; KW Host-virus interaction {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797036}; KW Membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797370}; KW Transmembrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797262}; KW Transmembrane helix {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797734}; KW Viral attachment to host cell {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797747}; KW Viral envelope protein {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797156, ECO:0000313|EMBL:AGF34672.1}; KW Viral penetration into host cytoplasm {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS01050355}; KW Virion {ECO:0000256|RuleBase:RU363095, ECO:0000256|SAAS:SAAS00796948}; KW Virus entry into host cell {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797206}. FT TRANSMEM 12 34 Helical. {ECO:0000256|RuleBase:RU363095}. FT TRANSMEM 502 525 Helical. {ECO:0000256|RuleBase:RU363095}. FT TRANSMEM 668 695 Helical. {ECO:0000256|RuleBase:RU363095}. FT DOMAIN 32 145 GP120. {ECO:0000259|Pfam:PF00516}. FT DOMAIN 137 501 GP120. {ECO:0000259|Pfam:PF00516}. FT DOMAIN 520 711 GP41. {ECO:0000259|Pfam:PF00517}. FT UNSURE 272 272 D or N. {ECO:0000313|EMBL:AGF34672.1}. SQ SEQUENCE 853 AA; 96371 MW; 08A2E3C1825E45EC CRC64; MRVTGIKKNW PLWKWGTMLL GMLMICSAEG NLWVTVYYGV PVWKEATTTL FCASDAKAYN AEAHNVWATH ACVPTDPDPQ EVVLENVTEN FNMWKNEMVN QMHEDVISLW DQSLKPCVKL TPLCVTLNCT NVTSNSNSVN NNSSLENTQE MKNCSFNTTT VVRDKKQQVY ALFYRLDIVP LTNSSEYRLI NCNTSAITQA CPKVSFDPIP IHYCTPAGYA LLKCNDERFN GTGPCHNVSS VQCTHGIKPV VSTQLLLNGS LAEKEIIVRS EDLTNNAKTI IVQLNKSVEI VCIRPGNNTR KSIRIGPGQT FYATGEIIGD IRQAHCNISG KDWEETLRNV SKKLAEHFQN KTIQFASSSG GDLEITTHSF NCRGEFFYCN TSGLFNKTYM HNDTLNSTEN WPXITIPCRI KQIINMWQEV GRAMYAPPIA GNITCKSNIT GLLLVRDGGA GSNDTEIFRP GGGDMRDNWR SELYKYKVVE IKPLGVAPTD AKRRVVEREK RAVGIGAVFL GFLGVAGSTM GAASLTLTVQ ARQLLSGIVQ QQSNLLRAIE AQQHMLQLTV WGIKQLQTRV LAIERYLKDQ QLLGIWGCSG KLICTTAVPW NSSWSNKSQK EIWDNMTWMQ WDKEISNYTD TIYRLLEVSQ NQQERNEKDL LALDSWKNLW NWFDITNWLW YIKIFIMIVG GLIGLRIIFA VLSIVKRVRE GYSPLSFQTP SHHQREPDRP EGIEEGGGEQ GRDRSVRLVS GFLAIVWDDL RSLCLFSYHR LRDFILIATR TVELLGHSSL KGLRRGWEGL KYLGNLLLYW GQELKISAIS LIDATAIATA GWTDRVIEAA QRAWLALLHI PRRIRQGFER ALV //