ID M1L269_9HIV1 Unreviewed; 853 AA. AC M1L269; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 17-FEB-2016, entry version 20. DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|SAAS:SAAS00411610}; DE AltName: Full=Endogenous retrovirus group K member 113 Env polyprotein {ECO:0000256|SAAS:SAAS00159454}; DE AltName: Full=Endogenous retrovirus group K member 13-1 Env polyprotein {ECO:0000256|SAAS:SAAS00411892}; DE AltName: Full=Endogenous retrovirus group K member 18 Env polyprotein {ECO:0000256|SAAS:SAAS00159191}; DE AltName: Full=Endogenous retrovirus group K member 19 Env polyprotein {ECO:0000256|SAAS:SAAS00411904}; DE AltName: Full=Endogenous retrovirus group K member 21 Env polyprotein {ECO:0000256|SAAS:SAAS00159138}; DE AltName: Full=Endogenous retrovirus group K member 24 Env polyprotein {ECO:0000256|SAAS:SAAS00159416}; DE AltName: Full=Endogenous retrovirus group K member 25 Env polyprotein {ECO:0000256|SAAS:SAAS00411846}; DE AltName: Full=Endogenous retrovirus group K member 6 Env polyprotein {ECO:0000256|SAAS:SAAS00411868}; DE AltName: Full=Endogenous retrovirus group K member 7 Env polyprotein {ECO:0000256|SAAS:SAAS00159103}; DE AltName: Full=Endogenous retrovirus group K member 8 Env polyprotein {ECO:0000256|SAAS:SAAS00159133}; DE AltName: Full=Endogenous retrovirus group K member 9 Env polyprotein {ECO:0000256|SAAS:SAAS00159347}; GN Name=env {ECO:0000313|EMBL:AGF34672.1}; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AGF34672.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AGF34672.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=2011.ANHUI.WH69 {ECO:0000313|EMBL:AGF34672.1}; RX PubMed=23372706; DOI=10.1371/journal.pone.0054322; RA Wu J., Meng Z., Xu J., Lei Y., Jin L., Zhong P., Han R., Su B.; RT "New Emerging Recombinant HIV-1 Strains and Close Transmission Linkage RT of HIV-1 Strains in the Chinese MSM Population Indicate a New Epidemic RT Risk."; RL PLoS ONE 8:E54322-E54322(2013). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC183781; AGF34672.1; -; Genomic_RNA. DR GO; GO:0044174; C:host cell endosome; IEA:UniProtKB-KW. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR Gene3D; 2.170.40.20; -; 2. DR InterPro; IPR000777; HIV1_GP160. DR InterPro; IPR000328; Retroviral_envelope_protein. DR Pfam; PF00516; GP120; 2. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; SSF56502; 2. PE 4: Predicted; KW Apoptosis {ECO:0000256|SAAS:SAAS00491382}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00487956}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|SAAS:SAAS00487637}; KW Host cell membrane {ECO:0000256|SAAS:SAAS00491210}; KW Host endosome {ECO:0000256|SAAS:SAAS00491443}; KW Host membrane {ECO:0000256|SAAS:SAAS00493156}; KW Host-virus interaction {ECO:0000256|RuleBase:RU003294, KW ECO:0000256|SAAS:SAAS00490508}; KW Membrane {ECO:0000256|SAAS:SAAS00491184, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|SAAS:SAAS00491847, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00490549, KW ECO:0000256|SAM:Phobius}; KW Viral attachment to host cell {ECO:0000256|SAAS:SAAS00490424}; KW Viral envelope protein {ECO:0000256|RuleBase:RU003294, KW ECO:0000256|SAAS:SAAS00490691, ECO:0000313|EMBL:AGF34672.1}; KW Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00486890}; KW Virion {ECO:0000256|SAAS:SAAS00491099}; KW Virus entry into host cell {ECO:0000256|SAAS:SAAS00490724}. FT TRANSMEM 12 34 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 502 525 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 668 695 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 32 145 GP120. {ECO:0000259|Pfam:PF00516}. FT DOMAIN 137 501 GP120. {ECO:0000259|Pfam:PF00516}. FT DOMAIN 520 711 GP41. {ECO:0000259|Pfam:PF00517}. FT UNSURE 272 272 D or N. {ECO:0000313|EMBL:AGF34672.1}. SQ SEQUENCE 853 AA; 96371 MW; 08A2E3C1825E45EC CRC64; MRVTGIKKNW PLWKWGTMLL GMLMICSAEG NLWVTVYYGV PVWKEATTTL FCASDAKAYN AEAHNVWATH ACVPTDPDPQ EVVLENVTEN FNMWKNEMVN QMHEDVISLW DQSLKPCVKL TPLCVTLNCT NVTSNSNSVN NNSSLENTQE MKNCSFNTTT VVRDKKQQVY ALFYRLDIVP LTNSSEYRLI NCNTSAITQA CPKVSFDPIP IHYCTPAGYA LLKCNDERFN GTGPCHNVSS VQCTHGIKPV VSTQLLLNGS LAEKEIIVRS EDLTNNAKTI IVQLNKSVEI VCIRPGNNTR KSIRIGPGQT FYATGEIIGD IRQAHCNISG KDWEETLRNV SKKLAEHFQN KTIQFASSSG GDLEITTHSF NCRGEFFYCN TSGLFNKTYM HNDTLNSTEN WPXITIPCRI KQIINMWQEV GRAMYAPPIA GNITCKSNIT GLLLVRDGGA GSNDTEIFRP GGGDMRDNWR SELYKYKVVE IKPLGVAPTD AKRRVVEREK RAVGIGAVFL GFLGVAGSTM GAASLTLTVQ ARQLLSGIVQ QQSNLLRAIE AQQHMLQLTV WGIKQLQTRV LAIERYLKDQ QLLGIWGCSG KLICTTAVPW NSSWSNKSQK EIWDNMTWMQ WDKEISNYTD TIYRLLEVSQ NQQERNEKDL LALDSWKNLW NWFDITNWLW YIKIFIMIVG GLIGLRIIFA VLSIVKRVRE GYSPLSFQTP SHHQREPDRP EGIEEGGGEQ GRDRSVRLVS GFLAIVWDDL RSLCLFSYHR LRDFILIATR TVELLGHSSL KGLRRGWEGL KYLGNLLLYW GQELKISAIS LIDATAIATA GWTDRVIEAA QRAWLALLHI PRRIRQGFER ALV //