ID   M0QZH7_HUMAN            Unreviewed;       161 AA.
AC   M0QZH7;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 57.
DE   SubName: Full=DMRT like family C2 {ECO:0000313|Ensembl:ENSP00000470553.1};
DE   Flags: Fragment;
GN   Name=DMRTC2 {ECO:0000313|Ensembl:ENSP00000470553.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000470553.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000470553.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000470553.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00070}.
CC   -!- SIMILARITY: Belongs to the DMRT family.
CC       {ECO:0000256|ARBA:ARBA00006834}.
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DR   EMBL; AC243967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M0QZH7; -.
DR   SMR; M0QZH7; -.
DR   MassIVE; M0QZH7; -.
DR   PeptideAtlas; M0QZH7; -.
DR   Antibodypedia; 30826; 153 antibodies from 22 providers.
DR   Ensembl; ENST00000596660.1; ENSP00000470553.1; ENSG00000142025.16.
DR   UCSC; uc060zda.1; human.
DR   HGNC; HGNC:13911; DMRTC2.
DR   VEuPathDB; HostDB:ENSG00000142025; -.
DR   GeneTree; ENSGT00940000161904; -.
DR   OMA; PLPWTPM; -.
DR   ChiTaRS; DMRTC2; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000142025; Expressed in right testis and 49 other cell types or tissues.
DR   ExpressionAtlas; M0QZH7; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 4.10.1040.10; DM DNA-binding domain; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR026607; DMRT.
DR   PANTHER; PTHR12322; DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT; 1.
DR   PANTHER; PTHR12322:SF15; DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR C2; 1.
DR   Pfam; PF00751; DM; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF82927; Cysteine-rich DNA binding domain, (DM domain); 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00070};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00070};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00070};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:M0QZH7,
KW   ECO:0007829|ProteomicsDB:M0QZH7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00070}.
FT   DOMAIN          42..89
FT                   /note="DM"
FT                   /evidence="ECO:0000259|PROSITE:PS50809"
FT   DNA_BIND        42..89
FT                   /note="DM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00070"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         161
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000470553.1"
SQ   SEQUENCE   161 AA;  17833 MW;  0E7F36DC073F8102 CRC64;
     MEPSDMPAGY HCPLDSAPWD ETRDPQSTEL IPRRAISRSP TCARCRNHGV TAHLKGHKRL
     CLFQACECHK CVLILERRRV MAAQVALRRQ QEAQLKKHLM RRGEASPKAP NHFRKGTTQP
     QVPSGKENIA PQPQTPHGAV LLAPTPPGKN SCGPLLLSHP P
//