ID L8IKQ5_9CETA Unreviewed; 307 AA. AC L8IKQ5; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 27-NOV-2024, entry version 58. DE RecName: Full=Cyclin-dependent kinase 5 activator {ECO:0000256|PIRNR:PIRNR009324}; GN ORFNames=E5288_WYG020630 {ECO:0000313|EMBL:MXQ84536.1}, M91_10428 GN {ECO:0000313|EMBL:ELR55712.1}; OS Bos mutus (wild yak). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR55712.1, ECO:0000313|Proteomes:UP000011080}; RN [1] {ECO:0000313|EMBL:ELR55712.1, ECO:0000313|Proteomes:UP000011080} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=YakQH1 {ECO:0000313|EMBL:ELR55712.1}, and yakQH1 RC {ECO:0000313|Proteomes:UP000011080}; RX PubMed=22751099; DOI=10.1038/ng.2343; RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J., RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y., RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y., RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T., RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R., RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P., RA Wang J., Liu J.; RT "The yak genome and adaptation to life at high altitude."; RL Nat. Genet. 44:946-949(2012). RN [2] {ECO:0000313|EMBL:MXQ84536.1, ECO:0000313|Proteomes:UP000322234} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WY2019 {ECO:0000313|EMBL:MXQ84536.1}; RC TISSUE=Blood {ECO:0000313|EMBL:MXQ84536.1}; RA Liu Y.; RT "The sequence and de novo assembly of the wild yak genome."; RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: p35 is a neuron specific activator of CDK5. The complex CC p35/CDK5 is required for neurite outgrowth and cortical lamination. CC Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 CC signaling. Activator of TPKII. The complex p35/CDK5 participates in the CC regulation of the circadian clock by modulating the function of CLOCK CC protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates CC the transcriptional activity of the CLOCK-BMAL1 heterodimer in CC association with altered stability and subcellular distribution. CC {ECO:0000256|ARBA:ARBA00037486}. CC -!- SUBUNIT: Heterodimer composed of a catalytic subunit CDK5 and a CC regulatory subunit CDK5R1 (p25) and macromolecular complex composed of CC at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only CC the heterodimer shows kinase activity. Interacts with EPHA4 and NGEF; CC may mediate the activation of NGEF by EPHA4. Interacts with RASGRF2. CC The complex p35/CDK5 interacts with CLOCK. CC {ECO:0000256|ARBA:ARBA00046889}. CC -!- SUBUNIT: Heterodimer of a catalytic subunit and a regulatory subunit. CC {ECO:0000256|PIRNR:PIRNR009324}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; CC Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004342}. Cell projection, neuron projection CC {ECO:0000256|ARBA:ARBA00004487}. Cytoplasm, perinuclear region CC {ECO:0000256|ARBA:ARBA00004556}. Nucleus CC {ECO:0000256|ARBA:ARBA00004123}. Perikaryon CC {ECO:0000256|ARBA:ARBA00004484}. CC -!- SIMILARITY: Belongs to the cyclin-dependent kinase 5 activator family. CC {ECO:0000256|ARBA:ARBA00010175, ECO:0000256|PIRNR:PIRNR009324}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JH881209; ELR55712.1; -; Genomic_DNA. DR EMBL; VBQZ03000021; MXQ84536.1; -; Genomic_DNA. DR RefSeq; XP_005896727.1; XM_005896665.2. DR AlphaFoldDB; L8IKQ5; -. DR SMR; L8IKQ5; -. DR STRING; 72004.ENSBMUP00000013103; -. DR Ensembl; ENSBMUT00000015177; ENSBMUP00000013103; ENSBMUG00000010012. DR GeneID; 102284508; -. DR KEGG; bom:102284508; -. DR CTD; 8851; -. DR OrthoDB; 2876525at2759; -. DR Proteomes; UP000011080; Unassembled WGS sequence. DR Proteomes; UP000322234; Unassembled WGS sequence. DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IEA:Ensembl. DR GO; GO:0030426; C:growth cone; IEA:TreeGrafter. DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl. DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016533; C:protein kinase 5 complex; IEA:UniProtKB-UniRule. DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl. DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IEA:Ensembl. DR GO; GO:0035255; F:ionotropic glutamate receptor binding; IEA:Ensembl. DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW. DR GO; GO:0002020; F:protease binding; IEA:Ensembl. DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl. DR GO; GO:0007411; P:axon guidance; IEA:Ensembl. DR GO; GO:0007413; P:axonal fasciculation; IEA:Ensembl. DR GO; GO:0021549; P:cerebellum development; IEA:Ensembl. DR GO; GO:0048013; P:ephrin receptor signaling pathway; IEA:Ensembl. DR GO; GO:0070315; P:G1 to G0 transition involved in cell differentiation; IEA:Ensembl. DR GO; GO:0021766; P:hippocampus development; IEA:Ensembl. DR GO; GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl. DR GO; GO:0007158; P:neuron cell-cell adhesion; IEA:Ensembl. DR GO; GO:0001764; P:neuron migration; IEA:Ensembl. DR GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl. DR GO; GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl. DR GO; GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl. DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl. DR GO; GO:0061001; P:regulation of dendritic spine morphogenesis; IEA:Ensembl. DR GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:Ensembl. DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW. DR GO; GO:0021722; P:superior olivary nucleus maturation; IEA:Ensembl. DR FunFam; 1.10.472.10:FF:000025; Cyclin-dependent kinase 5 activator; 1. DR Gene3D; 1.10.472.10; Cyclin-like; 1. DR InterPro; IPR004944; CDK5_activator. DR InterPro; IPR036915; Cyclin-like_sf. DR PANTHER; PTHR23401; CYCLIN DEPENDANT KINASE-5 ACTIVATOR; 1. DR PANTHER; PTHR23401:SF2; CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1; 1. DR Pfam; PF03261; CDK5_activator; 1. DR PIRSF; PIRSF009324; Cdk5_activator; 1. DR SUPFAM; SSF47954; Cyclin-like; 1. PE 3: Inferred from homology; KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Cell projection {ECO:0000256|ARBA:ARBA00023273}; KW Kinase {ECO:0000313|EMBL:ELR55712.1}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000011080}; KW Transferase {ECO:0000313|EMBL:ELR55712.1}; KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT REGION 97..135 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 111..129 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 307 AA; 34088 MW; 738F24F3F458EE68 CRC64; MGTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL PWKRIVAVSA KKKNSKKVQP NSSYQNNITH LNNENLKKSL SCANLSTFAQ PPPAQPPAPP ASQLSGSQTG VSSSVKKAPH PAVSSAGTPK RVIVQASTSE LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS VDRSLLLQGW QDQGFITPAN VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE ISYPLKPFLV ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR LLLGLDR //