ID   L8IKQ5_9CETA            Unreviewed;       307 AA.
AC   L8IKQ5;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=Cyclin-dependent kinase 5 activator {ECO:0000256|PIRNR:PIRNR009324};
GN   ORFNames=E5288_WYG020630 {ECO:0000313|EMBL:MXQ84536.1}, M91_10428
GN   {ECO:0000313|EMBL:ELR55712.1};
OS   Bos mutus (wild yak).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR55712.1, ECO:0000313|Proteomes:UP000011080};
RN   [1] {ECO:0000313|EMBL:ELR55712.1, ECO:0000313|Proteomes:UP000011080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YakQH1 {ECO:0000313|EMBL:ELR55712.1}, and yakQH1
RC   {ECO:0000313|Proteomes:UP000011080};
RX   PubMed=22751099; DOI=10.1038/ng.2343;
RA   Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA   Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA   Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA   Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA   Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA   Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA   Wang J., Liu J.;
RT   "The yak genome and adaptation to life at high altitude.";
RL   Nat. Genet. 44:946-949(2012).
RN   [2] {ECO:0000313|EMBL:MXQ84536.1, ECO:0000313|Proteomes:UP000322234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WY2019 {ECO:0000313|EMBL:MXQ84536.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:MXQ84536.1};
RA   Liu Y.;
RT   "The sequence and de novo assembly of the wild yak genome.";
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: p35 is a neuron specific activator of CDK5. The complex
CC       p35/CDK5 is required for neurite outgrowth and cortical lamination.
CC       Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4
CC       signaling. Activator of TPKII. The complex p35/CDK5 participates in the
CC       regulation of the circadian clock by modulating the function of CLOCK
CC       protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates
CC       the transcriptional activity of the CLOCK-BMAL1 heterodimer in
CC       association with altered stability and subcellular distribution.
CC       {ECO:0000256|ARBA:ARBA00037486}.
CC   -!- SUBUNIT: Heterodimer of a catalytic subunit and a regulatory subunit.
CC       {ECO:0000256|PIRNR:PIRNR009324}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004342};
CC       Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004342}. Cell projection, neuron projection
CC       {ECO:0000256|ARBA:ARBA00004487}. Cytoplasm, perinuclear region
CC       {ECO:0000256|ARBA:ARBA00004556}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor
CC       {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004423}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}. Perikaryon
CC       {ECO:0000256|ARBA:ARBA00004484}.
CC   -!- SIMILARITY: Belongs to the cyclin-dependent kinase 5 activator family.
CC       {ECO:0000256|ARBA:ARBA00010175, ECO:0000256|PIRNR:PIRNR009324}.
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DR   EMBL; JH881209; ELR55712.1; -; Genomic_DNA.
DR   EMBL; VBQZ03000021; MXQ84536.1; -; Genomic_DNA.
DR   RefSeq; XP_005896727.1; XM_005896665.2.
DR   AlphaFoldDB; L8IKQ5; -.
DR   SMR; L8IKQ5; -.
DR   STRING; 72004.ENSBMUP00000013103; -.
DR   Ensembl; ENSBMUT00000015177; ENSBMUP00000013103; ENSBMUG00000010012.
DR   GeneID; 102284508; -.
DR   KEGG; bom:102284508; -.
DR   CTD; 8851; -.
DR   OrthoDB; 2876525at2759; -.
DR   Proteomes; UP000011080; Unassembled WGS sequence.
DR   Proteomes; UP000322234; Unassembled WGS sequence.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IEA:Ensembl.
DR   GO; GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016533; C:protein kinase 5 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR   GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IEA:Ensembl.
DR   GO; GO:0035255; F:ionotropic glutamate receptor binding; IEA:Ensembl.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR   GO; GO:0007413; P:axonal fasciculation; IEA:Ensembl.
DR   GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
DR   GO; GO:0048013; P:ephrin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0070315; P:G1 to G0 transition involved in cell differentiation; IEA:Ensembl.
DR   GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR   GO; GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR   GO; GO:0007158; P:neuron cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0061001; P:regulation of dendritic spine morphogenesis; IEA:Ensembl.
DR   GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   GO; GO:0021722; P:superior olivary nucleus maturation; IEA:Ensembl.
DR   Gene3D; 1.10.472.10; Cyclin-like; 1.
DR   InterPro; IPR004944; CDK5_activator.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   PANTHER; PTHR23401; CYCLIN DEPENDANT KINASE-5 ACTIVATOR; 1.
DR   PANTHER; PTHR23401:SF2; CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1; 1.
DR   Pfam; PF03261; CDK5_activator; 1.
DR   PIRSF; PIRSF009324; Cdk5_activator; 1.
DR   SUPFAM; SSF47954; Cyclin-like; 1.
PE   3: Inferred from homology;
KW   Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Kinase {ECO:0000313|EMBL:ELR55712.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW   Transferase {ECO:0000313|EMBL:ELR55712.1};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   REGION          97..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..129
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  34088 MW;  738F24F3F458EE68 CRC64;
     MGTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL PWKRIVAVSA
     KKKNSKKVQP NSSYQNNITH LNNENLKKSL SCANLSTFAQ PPPAQPPAPP ASQLSGSQTG
     VSSSVKKAPH PAVSSAGTPK RVIVQASTSE LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS
     VDRSLLLQGW QDQGFITPAN VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE
     ISYPLKPFLV ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR
     LLLGLDR
//