ID   L8IKQ5_9CETA            Unreviewed;       307 AA.
AC   L8IKQ5;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Cyclin-dependent kinase 5 activator {ECO:0000256|PIRNR:PIRNR009324};
GN   ORFNames=E5288_WYG020630 {ECO:0000313|EMBL:MXQ84536.1}, M91_10428
GN   {ECO:0000313|EMBL:ELR55712.1};
OS   Bos mutus (wild yak).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR55712.1, ECO:0000313|Proteomes:UP000011080};
RN   [1] {ECO:0000313|EMBL:ELR55712.1, ECO:0000313|Proteomes:UP000011080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YakQH1 {ECO:0000313|EMBL:ELR55712.1}, and yakQH1
RC   {ECO:0000313|Proteomes:UP000011080};
RX   PubMed=22751099; DOI=10.1038/ng.2343;
RA   Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA   Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA   Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA   Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA   Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA   Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA   Wang J., Liu J.;
RT   "The yak genome and adaptation to life at high altitude.";
RL   Nat. Genet. 44:946-949(2012).
RN   [2] {ECO:0000313|EMBL:MXQ84536.1, ECO:0000313|Proteomes:UP000322234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WY2019 {ECO:0000313|EMBL:MXQ84536.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:MXQ84536.1};
RA   Liu Y.;
RT   "The sequence and de novo assembly of the wild yak genome.";
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Heterodimer of a catalytic subunit and a regulatory subunit.
CC       {ECO:0000256|PIRNR:PIRNR009324}.
CC   -!- SIMILARITY: Belongs to the cyclin-dependent kinase 5 activator family.
CC       {ECO:0000256|ARBA:ARBA00010175, ECO:0000256|PIRNR:PIRNR009324}.
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DR   EMBL; JH881209; ELR55712.1; -; Genomic_DNA.
DR   EMBL; VBQZ03000021; MXQ84536.1; -; Genomic_DNA.
DR   RefSeq; XP_005896727.1; XM_005896665.2.
DR   SMR; L8IKQ5; -.
DR   STRING; 72004.XP_005896727.1; -.
DR   Ensembl; ENSBMUT00000015177; ENSBMUP00000013103; ENSBMUG00000010012.
DR   GeneID; 102284508; -.
DR   KEGG; bom:102284508; -.
DR   CTD; 8851; -.
DR   Proteomes; UP000011080; Unassembled WGS sequence.
DR   Proteomes; UP000322234; Unassembled WGS sequence.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0016533; C:protein kinase 5 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR   GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IEA:Ensembl.
DR   GO; GO:0035255; F:ionotropic glutamate receptor binding; IEA:Ensembl.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR   GO; GO:0007413; P:axonal fasciculation; IEA:Ensembl.
DR   GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
DR   GO; GO:0048013; P:ephrin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0070315; P:G1 to G0 transition involved in cell differentiation; IEA:Ensembl.
DR   GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR   GO; GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0007158; P:neuron cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR   GO; GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0061001; P:regulation of dendritic spine morphogenesis; IEA:Ensembl.
DR   GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0042501; P:serine phosphorylation of STAT protein; IEA:Ensembl.
DR   GO; GO:0021722; P:superior olivary nucleus maturation; IEA:Ensembl.
DR   InterPro; IPR004944; CDK5_activator.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   PANTHER; PTHR23401; PTHR23401; 1.
DR   Pfam; PF03261; CDK5_activator; 1.
DR   PIRSF; PIRSF009324; Cdk5_activator; 1.
DR   SUPFAM; SSF47954; SSF47954; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|EMBL:ELR55712.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW   Transferase {ECO:0000313|EMBL:ELR55712.1}.
FT   REGION          97..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..129
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  34088 MW;  738F24F3F458EE68 CRC64;
     MGTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL PWKRIVAVSA
     KKKNSKKVQP NSSYQNNITH LNNENLKKSL SCANLSTFAQ PPPAQPPAPP ASQLSGSQTG
     VSSSVKKAPH PAVSSAGTPK RVIVQASTSE LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS
     VDRSLLLQGW QDQGFITPAN VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE
     ISYPLKPFLV ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR
     LLLGLDR
//