ID   L8IKQ5_9CETA            Unreviewed;       307 AA.
AC   L8IKQ5;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   22-APR-2020, entry version 39.
DE   RecName: Full=Cyclin-dependent kinase 5 activator {ECO:0000256|PIRNR:PIRNR009324};
GN   ORFNames=M91_10428 {ECO:0000313|EMBL:ELR55712.1};
OS   Bos mutus (wild yak).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR55712.1, ECO:0000313|Proteomes:UP000011080};
RN   [1] {ECO:0000313|EMBL:ELR55712.1, ECO:0000313|Proteomes:UP000011080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX   PubMed=22751099; DOI=10.1038/ng.2343;
RA   Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA   Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA   Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA   Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA   Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA   Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA   Wang J., Liu J.;
RT   "The yak genome and adaptation to life at high altitude.";
RL   Nat. Genet. 44:946-949(2012).
CC   -!- SUBUNIT: Heterodimer of a catalytic subunit and a regulatory subunit.
CC       {ECO:0000256|PIRNR:PIRNR009324}.
CC   -!- SIMILARITY: Belongs to the cyclin-dependent kinase 5 activator family.
CC       {ECO:0000256|PIRNR:PIRNR009324}.
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DR   EMBL; JH881209; ELR55712.1; -; Genomic_DNA.
DR   RefSeq; XP_005896727.1; XM_005896665.2.
DR   SMR; L8IKQ5; -.
DR   Ensembl; ENSBMUT00000015177; ENSBMUP00000013103; ENSBMUG00000010012.
DR   GeneID; 102284508; -.
DR   KEGG; bom:102284508; -.
DR   CTD; 8851; -.
DR   KO; K11716; -.
DR   Proteomes; UP000011080; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0016533; C:protein kinase 5 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR   GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IEA:Ensembl.
DR   GO; GO:0035255; F:ionotropic glutamate receptor binding; IEA:Ensembl.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR   GO; GO:0007413; P:axonal fasciculation; IEA:Ensembl.
DR   GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
DR   GO; GO:0048013; P:ephrin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR   GO; GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
DR   GO; GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0007158; P:neuron cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR   GO; GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
DR   GO; GO:0071158; P:positive regulation of cell cycle arrest; IEA:Ensembl.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0061001; P:regulation of dendritic spine morphogenesis; IEA:Ensembl.
DR   GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0042501; P:serine phosphorylation of STAT protein; IEA:Ensembl.
DR   GO; GO:0021722; P:superior olivary nucleus maturation; IEA:Ensembl.
DR   InterPro; IPR004944; CDK5_activator.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   PANTHER; PTHR23401; PTHR23401; 1.
DR   Pfam; PF03261; CDK5_activator; 1.
DR   PIRSF; PIRSF009324; Cdk5_activator; 1.
DR   SUPFAM; SSF47954; SSF47954; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|EMBL:ELR55712.1};
KW   Transferase {ECO:0000313|EMBL:ELR55712.1}.
SQ   SEQUENCE   307 AA;  34088 MW;  738F24F3F458EE68 CRC64;
     MGTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL PWKRIVAVSA
     KKKNSKKVQP NSSYQNNITH LNNENLKKSL SCANLSTFAQ PPPAQPPAPP ASQLSGSQTG
     VSSSVKKAPH PAVSSAGTPK RVIVQASTSE LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS
     VDRSLLLQGW QDQGFITPAN VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE
     ISYPLKPFLV ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR
     LLLGLDR
//