ID   L7YCG8_9FLAO            Unreviewed;       943 AA.
AC   L7YCG8;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   12-APR-2017, entry version 33.
DE   RecName: Full=Leucine--tRNA ligase {ECO:0000256|HAMAP-Rule:MF_00049};
DE            EC=6.1.1.4 {ECO:0000256|HAMAP-Rule:MF_00049};
DE   AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00049};
DE            Short=LeuRS {ECO:0000256|HAMAP-Rule:MF_00049};
GN   Name=leuS {ECO:0000256|HAMAP-Rule:MF_00049};
GN   ORFNames=BLBBOR_124 {ECO:0000313|EMBL:AGD98032.1};
OS   Blattabacterium sp. (Blatta orientalis) str. Tarazona.
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Blattabacteriaceae; Blattabacterium.
OX   NCBI_TaxID=1072467 {ECO:0000313|EMBL:AGD98032.1, ECO:0000313|Proteomes:UP000011228};
RN   [1] {ECO:0000313|EMBL:AGD98032.1, ECO:0000313|Proteomes:UP000011228}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tarazona {ECO:0000313|EMBL:AGD98032.1,
RC   ECO:0000313|Proteomes:UP000011228};
RX   PubMed=23355305; DOI=10.1093/gbe/evt011;
RA   Patino-Navarrete R., Moya A., Latorre A., Pereto J.;
RT   "Comparative genomics of Blattabacterium cuenoti: the frozen legacy of
RT   an ancient endosymbiont genome.";
RL   Genome Biol. Evol. 5:351-361(2013).
CC   -!- CATALYTIC ACTIVITY: ATP + L-leucine + tRNA(Leu) = AMP +
CC       diphosphate + L-leucyl-tRNA(Leu). {ECO:0000256|HAMAP-
CC       Rule:MF_00049}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00049}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase
CC       family. {ECO:0000256|HAMAP-Rule:MF_00049,
CC       ECO:0000256|RuleBase:RU363039}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_00049}.
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DR   EMBL; CP003605; AGD98032.1; -; Genomic_DNA.
DR   RefSeq; WP_015370523.1; NC_020195.1.
DR   EnsemblBacteria; AGD98032; AGD98032; BLBBOR_124.
DR   KEGG; bbq:BLBBOR_124; -.
DR   KO; K01869; -.
DR   OrthoDB; POG091H01JZ; -.
DR   Proteomes; UP000011228; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:UniProtKB-HAMAP.
DR   Gene3D; 1.10.730.10; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00049_B; Leu_tRNA_synth_B; 1.
DR   InterPro; IPR002302; Leu-tRNA-ligase.
DR   InterPro; IPR025709; Leu_tRNA-synth_edit.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   PANTHER; PTHR43740; PTHR43740; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF13603; tRNA-synt_1_2; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 1.
DR   PRINTS; PR00985; TRNASYNTHLEU.
DR   SUPFAM; SSF47323; SSF47323; 1.
DR   SUPFAM; SSF50677; SSF50677; 1.
DR   TIGRFAMs; TIGR00396; leuS_bact; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00049,
KW   ECO:0000256|RuleBase:RU363039, ECO:0000313|EMBL:AGD98032.1};
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00049,
KW   ECO:0000256|RuleBase:RU363039};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011228};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00049};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00049,
KW   ECO:0000256|RuleBase:RU363039, ECO:0000313|EMBL:AGD98032.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00049,
KW   ECO:0000256|RuleBase:RU363039};
KW   Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00049,
KW   ECO:0000256|RuleBase:RU363039}.
FT   DOMAIN       36    145       tRNA-synt_1g. {ECO:0000259|Pfam:PF09334}.
FT   DOMAIN      279    460       tRNA-synt_1_2. {ECO:0000259|Pfam:
FT                                PF13603}.
FT   DOMAIN      794    905       Anticodon_1. {ECO:0000259|Pfam:PF08264}.
FT   MOTIF       717    721       "KMSKS" region. {ECO:0000256|HAMAP-Rule:
FT                                MF_00049}.
FT   BINDING     720    720       ATP. {ECO:0000256|HAMAP-Rule:MF_00049}.
SQ   SEQUENCE   943 AA;  111224 MW;  6D4296F8C1BFCA33 CRC64;
     MEYNFREIEK RWQIFWKKHN IFHTKENNGN KSSKYYILNM FPYPSGSGLH IGHCLGYIAS
     DIYARYKRTT GHNVLFPIGF DSFGLPAEQY AIQTGQHPFK TTRQNVKKYQ SQMDKIGLSF
     DWSRKLSTSD PTYYRWTQWM FIQIFNSWYD KTSEKAKSID LLVEEFNKNG NLLVNASHSL
     NYKFDSKMWK EFNSSKKESI LLNYRLAFLC ENTVNWCPGL GTVLANDEIT NGRSQRGGYP
     IHRKKMLQWH IRITAYIERL LKGLESVDCS KSLKKLQYNW IGKTLGYSIF LELFFQNQKE
     NIKRIELFIS RPETIFGMTF IILSTDHPMA EKISISSHRE EVSLYCKKNL VEEKNISGVF
     TGNYVIHPFI KKKKIPIYVS NSFSVDHETL SIIGVPGHEK ICKKFAKNMD LEVLSVLTPE
     KKEENTNNEL YEGKNGICIN SDFLNGLKVQ EAKKKVIQIL EEKNIGFKKN SYRLRDAIFS
     RQRYWGEPIP IYFKNKIPKT IPLEKLPLLL PEINNYHPKN GKSPLTRVKN WAWDERKMKI
     VSNTLVDNKY VFPIETSTMP SWAGSSWYFL RYMDAHNNQF FLDKKKEHIW KNIDLYIGGA
     EHSTGHLIYA RFWHKFLKDR GWVSTEEPFK KIFNQGMILN YSATILKIIG KNIFISYGLR
     NSHNQGENLQ KIYVDISLVN SNNELDINKF QDSRPEFSQA KFFLEKGRFF CQRQLEKMSK
     SKYNVITPDK ISEKYGSDIF RLYEMFLGPV MESKPWNEEK INGIKNFLNK FLRLFHINKV
     FQVSDLDPTF QELKILHHTI KKLQEKINSF SFNTSISYLM IMVNQLSILK CNKRKILEPL
     VKLIAPFSPH IAEELWRKLG KEKSIIFYPF PVYDQKFLVK EKITYPIMFN GKLKFQETFE
     SKLTIEEIRK KILNHPKIKF ILDEKILQKI IIIPKKIINI LFI
//