ID L7SVA5_9HEPC Unreviewed; 554 AA. AC L7SVA5; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 08-NOV-2023, entry version 25. DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107}; DE Flags: Fragment; OS Hepacivirus hominis. OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; OC Amarillovirales; Flaviviridae; Hepacivirus. OX NCBI_TaxID=3052230 {ECO:0000313|EMBL:AGC23312.1}; RN [1] {ECO:0000313|EMBL:AGC23312.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=OBSHCVFR_P75 {ECO:0000313|EMBL:AGC23312.1}; RA Schvoerer E., Moenne-Loccoz R., Murray J.M., Velay A., Turek M., Fofana I., RA Fafi-Kremer S., Erba A.-C., Habersetzer F., Doffoel M., Gut J.-P., RA Donlin M.J., Tavis J.E., Zeisel M.B., Stoll-Keller F., Baumert T.F.; RT "Hepatitis C virus envelope glycoprotein signatures are associated with RT treatment failure and modulation of viral entry and neutralization."; RL J. Infect. Dis. 0:0-0(2013). CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004115}. Host endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004482}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004482}. Host lipid droplet CC {ECO:0000256|ARBA:ARBA00004338}. Lipid droplet CC {ECO:0000256|ARBA:ARBA00004502}. Membrane CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004563}. CC -!- SIMILARITY: Belongs to the hepacivirus polyprotein family. CC {ECO:0000256|ARBA:ARBA00008286}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC256901; AGC23312.1; -; Genomic_RNA. DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0044186; C:host cell lipid droplet; IEA:UniProtKB-SubCell. DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW. DR Gene3D; 3.30.160.890; Hepatitis C virus envelope glycoprotein E1, chain C; 1. DR InterPro; IPR002519; HCV_Env. DR InterPro; IPR002531; HCV_NS1. DR Pfam; PF01539; HCV_env; 1. DR Pfam; PF01560; HCV_NS1; 1. PE 3: Inferred from homology; KW Clathrin-mediated endocytosis of virus by host KW {ECO:0000256|ARBA:ARBA00022570}; KW Fusion of virus membrane with host endosomal membrane KW {ECO:0000256|ARBA:ARBA00022510}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|ARBA:ARBA00022510}; KW Host lipid droplet {ECO:0000256|ARBA:ARBA00023190}; KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879}; KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595}; KW Virion {ECO:0000256|ARBA:ARBA00022879}; KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890}; KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00022570}. FT DOMAIN 2..191 FT /note="Hepatitis C virus Envelope glycoprotein E1" FT /evidence="ECO:0000259|Pfam:PF01539" FT DOMAIN 196..538 FT /note="Hepatitis C virus Non-structural protein E2/NS1" FT /evidence="ECO:0000259|Pfam:PF01560" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AGC23312.1" FT NON_TER 554 FT /evidence="ECO:0000313|EMBL:AGC23312.1" SQ SEQUENCE 554 AA; 61254 MW; AD63BC569DE73DD0 CRC64; YEVRNASGVY HVTNDCSNSS IVYEATDMIM HTPGCVPCVR ENNSSRCWVP LTPTLAARNT SIPTTTIRRH VDLLVGAAAL CSAMYVGDLC GSVLLVSQLF TFSPRRHETV QDCNCSIYPG RVSGHRMAWD MMMNWSPTTA LVVSQLLRIP QAVMDVVAGA HWGILAGLAY YSMVGNWAKV LIVMLLFAGV DGNTYTSGGA AGHATSRFAS LFNLGSAQKL QLINTNGSWH INRTALNCND SYQTGFIAAL FYRHNFNASG CPERLASCRS IDKFSQGWGP ITYAEPEDSD QRPYCWHYAP RQCGVVNASK VCGPVYCFTP SPVVVGTTDR SGVPTYSWGE NETDVLLLNN TRPPQGNWFG CTWMNSTGFT KTCGGPPCKI GGAGNNTLTC PTDCFRKHPE ATYTKCGSGP WLTPRCLVDY PYRLWHYPCT VNFTVFKVRM YVGGVEHRLN AACNWTRGER CDLEDRDRSE LSPLLLSTTE WQILPCSFTT LPALSTGLIH LHQNIVDVQY LYGIGSAVVS FAVKWEYVML LFFFLADARV CACLWMMLLI AQAE //