ID L7R5S6_MEGLY Unreviewed; 1247 AA. AC L7R5S6; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 07-OCT-2020, entry version 32. DE RecName: Full=Unconventional myosin-6 {ECO:0000256|ARBA:ARBA00018603}; DE AltName: Full=Unconventional myosin-VI {ECO:0000256|ARBA:ARBA00015382}; DE Flags: Fragment; GN Name=Myo6 {ECO:0000313|EMBL:AGB93866.1}; OS Megaderma lyra (Greater false vampire bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Megadermatidae; OC Megaderma. OX NCBI_TaxID=9413 {ECO:0000313|EMBL:AGB93866.1}; RN [1] {ECO:0000313|EMBL:AGB93866.1} RP NUCLEOTIDE SEQUENCE. RA Shen B., Han X., Jones G., Rossiter S.J., Zhang S.; RT "Adaptive evolution of the Myo6 gene in Old World fruit bats (Family: RT Pteropodidae)."; RL PLoS ONE 8:E62307-E62307(2013). CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium CC {ECO:0000256|ARBA:ARBA00004486}. Cell projection, microvillus CC {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle membrane CC {ECO:0000256|ARBA:ARBA00004632}. Cytoplasm, cytosol CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasm, perinuclear region CC {ECO:0000256|ARBA:ARBA00004556}. Cytoplasmic vesicle, clathrin-coated CC vesicle {ECO:0000256|ARBA:ARBA00004132}. Golgi apparatus, trans-Golgi CC network membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane CC protein {ECO:0000256|ARBA:ARBA00004150}. Membrane CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004170}. Nucleus CC {ECO:0000256|ARBA:ARBA00004123}. Vesicle CC {ECO:0000256|ARBA:ARBA00004373}. CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314, CC ECO:0000256|PROSITE-ProRule:PRU00782}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JX023450; AGB93866.1; -; mRNA. DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-KW. DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell. DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell. DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. DR GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell. DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0051015; F:actin filament binding; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0003774; F:motor activity; IEA:UniProtKB-UniRule. DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW. DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW. DR CDD; cd01382; MYSc_Myo6; 1. DR Gene3D; 2.30.30.360; -; 1. DR Gene3D; 3.40.850.10; -; 1. DR InterPro; IPR036961; Kinesin_motor_dom_sf. DR InterPro; IPR032412; Myosin-VI_CBD. DR InterPro; IPR001609; Myosin_head_motor_dom. DR InterPro; IPR004009; Myosin_N. DR InterPro; IPR008989; Myosin_S1_N. DR InterPro; IPR036114; MYSc_Myo6. DR InterPro; IPR027417; P-loop_NTPase. DR Pfam; PF16521; Myosin-VI_CBD; 1. DR Pfam; PF00063; Myosin_head; 1. DR PRINTS; PR00193; MYOSINHEAVY. DR SMART; SM00242; MYSc; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS51456; MYOSIN_MOTOR; 1. DR PROSITE; PS51844; SH3_LIKE; 1. PE 2: Evidence at transcript level; KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE- KW ProRule:PRU00782}; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU00782}; Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Cell projection {ECO:0000256|ARBA:ARBA00023273}; KW Coated pit {ECO:0000256|ARBA:ARBA00023176}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Endocytosis {ECO:0000256|ARBA:ARBA00022583}; KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034}; KW Hearing {ECO:0000256|ARBA:ARBA00022740}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE- KW ProRule:PRU00782}; KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE- KW ProRule:PRU00782}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU00782}; Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Protein transport {ECO:0000256|ARBA:ARBA00022927}; KW Transport {ECO:0000256|ARBA:ARBA00022927}. FT DOMAIN 1..45 FT /note="Myosin N-terminal SH3-like" FT /evidence="ECO:0000259|PROSITE:PS51844" FT DOMAIN 49..763 FT /note="Myosin motor" FT /evidence="ECO:0000259|PROSITE:PS51456" FT NP_BIND 143..150 FT /note="ATP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782" FT REGION 643..665 FT /note="Actin-binding" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782" FT REGION 926..947 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1087..1134 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 856..890 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 1087..1101 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1108..1134 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AGB93866.1" FT NON_TER 1247 FT /evidence="ECO:0000313|EMBL:AGB93866.1" SQ SEQUENCE 1247 AA; 144148 MW; 16C7E3762932623A CRC64; APHPTDGFQM GNIVDIGPDS LTIEPLNQKG KTFLALINQV FPAEEDSKKD VEDNCSLMYL NEATLLHNIK VRYSKDRIYT YVANILIAVN PYFDIPKIYS SETIKSYQGK SLGTMPPHVF AIADKAFRDM KVLKMSQSII VSGESGAGKT ENTKFVLRYL TESYGTGQDI DDRIVEANPL LEAFGNAKTV RNNNSSRFGK FVEIHFNEKS SVVGGFVSHY LLEKSRICVQ GKEERNYHIF YRLCAGASED IQEKLHLSSP DNFRYLNRGC TRYFATKETD KQILQNRKSP EYLKAGSLKD PLLDDHGDFI RMCTAMKKIG LDDDEKLDLF RVVAGVLHLG NIDFEEAGSS SGGCNLKNKS TQSLEYCAEL LGLDQDDLRV SLTTRVMLTT AGGTKGTVIK VPLKVEQANN ARDALAKTVY SHLFDHVVNR VNQCFPFETS SYFIGVLDIA GFEYFEHNSF EQFCINYCNE KLQQFFNERI LKEEQELYQK EGLGVNEVHY VDNQDCIDLI EAKLVGILDI LDEENRLPQP SDQHFTSAVH QKHKDHFRLT IPRKSKLAVH RNIRDDEGFI IRHFAGAVCY ETTQFVEKNN DALHMSLESL ICESRDKFIR ELFESSTNNN KDTKQKAGKL SFISVGNKFK TQLNLLLDKL RSTGASFIRC IKPNLKMTSH HFEGAQILSQ LQCSGMVSVL DLMQGGFPSR ASFHELYNMY KKYMPDKLAR LDPRLFCKAL FKALGLNEID YKFGLTKVFF RPGKFAEFDQ IMKSDPDHLA ELVKRVNHWL ICSRWKKVQW CSLSVIKLKN KIKYRAEACI KMQKTIRMWL CKRRHKPRID GLVKVGTLRK RIDKFNEVVS ALKDGKPEVN KQIKDLEISI DALMAKIKST MMTREQIQKE YDALVKSSEE LLSALQKKKQ QEEEAERLRR IQEEMEKERK RREEDEQRRR KEEEERRMKL DMEAKRKQEE EERKKREDDE KRIQAEVEEQ LARQREEESQ QQAVLEQERR DRELALRIAQ SEAELISDEA QADLALRRGP AVQATKAAAG TKKHDLSKWK YAELRDTINT SCDIELLAAC REEFHRRLKV YHAWKSKNKK RNTETEQRAP KSVTDYDFAP FLNSSPQQNP AAQRPARQQA VETDRQQRFF RIPFIRPADQ YKDPQSKKKG WWYAHFDGPW IARQMELHPD KPPILLVAGK DDMEMCELNL EETGLTRKRG AEILPRQFEE IWERCGGIQY LQNAIESRQA RPTYATA //