ID L7QI57_9MONO Unreviewed; 676 AA. AC L7QI57; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 14-DEC-2022, entry version 41. DE SubName: Full=Envelope glycoprotein {ECO:0000313|EMBL:AQA27304.1}; DE SubName: Full=Virion spike glycoprotein {ECO:0000313|EMBL:AGB56830.1}; GN Name=GP {ECO:0000313|EMBL:AGB56830.1}; OS Zaire ebolavirus. OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; OC Monjiviricetes; Mononegavirales; Filoviridae; Ebolavirus. OX NCBI_TaxID=186538 {ECO:0000313|EMBL:AGB56830.1, ECO:0000313|Proteomes:UP000144463}; RN [1] {ECO:0000313|EMBL:AGB56830.1, ECO:0000313|Proteomes:UP000144463} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=EBOV/H.sapiens-tc/GAB/2002/Ilembe RC {ECO:0000313|EMBL:AGB56830.1}; RX PubMed=23255795; DOI=10.1128/JVI.03118-12; RA Carroll S.A., Towner J.S., Sealy T.K., McMullan L.K., Khristova M.L., RA Burt F.J., Swanepoel R., Rollin P.E., Nichol S.T.; RT "Molecular evolution of viruses of the family filoviridae based on 97 RT whole-genome sequences."; RL J. Virol. 87:2608-2616(2013). RN [2] {ECO:0007829|PDB:2MB1} RP STRUCTURE BY NMR OF 507-560, AND DISULFIDE BONDS. RX PubMed=24696482; DOI=10.1128/JVI.00396-14; RA Gregory S.M., Larsson P., Nelson E.A., Kasson P.M., White J.M., Tamm L.K.; RT "Ebolavirus entry requires a compact hydrophobic fist at the tip of the RT fusion loop."; RL J. Virol. 88:6636-6649(2014). RN [3] {ECO:0000313|EMBL:AQA27304.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Ebola virus/cynomolgus macaque-wt/GAB/2001/1000ffu-CB821D5 RC {ECO:0000313|EMBL:AQA27484.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/1000ffu-CB821D7 {ECO:0000313|EMBL:AQA27493.1}, RC Ebola virus/cynomolgus macaque-wt/GAB/2001/1000ffu-CB821D9 RC {ECO:0000313|EMBL:AQA27502.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/1000ffu-CB829D7 {ECO:0000313|EMBL:AQA27511.1}, RC Ebola virus/cynomolgus macaque-wt/GAB/2001/1000ffu-CB829D9 RC {ECO:0000313|EMBL:AQA27520.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/1000ffu-CC089D7 {ECO:0000313|EMBL:AQA27304.1}, RC Ebola virus/cynomolgus macaque-wt/GAB/2001/1000ffu-CC089D9 RC {ECO:0000313|EMBL:AQA27313.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/100ffu-CA881D5 {ECO:0000313|EMBL:AQA27529.1}, RC Ebola virus/cynomolgus macaque-wt/GAB/2001/100ffu-CA881D7 RC {ECO:0000313|EMBL:AQA27538.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/100ffu-CA881D9 {ECO:0000313|EMBL:AQA27547.1}, RC Ebola virus/cynomolgus macaque-wt/GAB/2001/100ffu-CA952D5 RC {ECO:0000313|EMBL:AQA27556.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/100ffu-CA952D7 {ECO:0000313|EMBL:AQA27565.1}, RC Ebola virus/cynomolgus macaque-wt/GAB/2001/100ffu-CA952D9 RC {ECO:0000313|EMBL:AQA27574.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/100ffu-CB118D7 {ECO:0000313|EMBL:AQA27331.1}, RC Ebola virus/cynomolgus macaque-wt/GAB/2001/100ffu-CB118D9 RC {ECO:0000313|EMBL:AQA27340.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/100ffu-CB748D5 {ECO:0000313|EMBL:AQA27430.1}, RC Ebola virus/cynomolgus macaque-wt/GAB/2001/100ffu-CB748D7 RC {ECO:0000313|EMBL:AQA27439.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/100ffu-CB748D9 {ECO:0000313|EMBL:AQA27448.1}, RC Ebola virus/cynomolgus macaque-wt/GAB/2001/100ffu-CB760D5 RC {ECO:0000313|EMBL:AQA27457.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/100ffu-CB760D7 {ECO:0000313|EMBL:AQA27466.1}, RC Ebola virus/cynomolgus macaque-wt/GAB/2001/100ffu-CB760D9 RC {ECO:0000313|EMBL:AQA27475.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/10ffu-CA954D5 {ECO:0000313|EMBL:AQA27583.1}, Ebola RC virus/cynomolgus macaque-wt/GAB/2001/10ffu-CA954D7 RC {ECO:0000313|EMBL:AQA27592.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/10ffu-CA954D9 {ECO:0000313|EMBL:AQA27601.1}, Ebola RC virus/cynomolgus macaque-wt/GAB/2001/10ffu-CB145D5 RC {ECO:0000313|EMBL:AQA27349.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/10ffu-CB145D7 {ECO:0000313|EMBL:AQA27358.1}, Ebola RC virus/cynomolgus macaque-wt/GAB/2001/10ffu-CB145D9 RC {ECO:0000313|EMBL:AQA27367.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/10ffu-CB633D5 {ECO:0000313|EMBL:AQA27376.1}, Ebola RC virus/cynomolgus macaque-wt/GAB/2001/10ffu-CB633D7 RC {ECO:0000313|EMBL:AQA27385.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/10ffu-CB633D9 {ECO:0000313|EMBL:AQA27394.1}, Ebola RC virus/cynomolgus macaque-wt/GAB/2001/10ffu-CB661D5 RC {ECO:0000313|EMBL:AQA27403.1}, Ebola virus/cynomolgus RC macaque-wt/GAB/2001/10ffu-CB661D7 {ECO:0000313|EMBL:AQA27412.1}, Ebola RC virus/cynomolgus macaque-wt/GAB/2001/10ffu-CB661D9 RC {ECO:0000313|EMBL:AQA27421.1}, and Ebola RC virus/Hsapiens-tc/GAB/2011/inoculum strain Gabon 2001 RC {ECO:0000313|EMBL:AQA27610.1}; RX PubMed=28132865; DOI=10.1016/j.antiviral.2017.01.017; RA Piorkowski G., Jacquot F., Querat G., Carbonnelle C., Pannetier D., RA Mentre F., Raoul H., de Lamballerie X.; RT "Implementation of a non-human primate model of Ebola disease: Infection of RT Mauritian cynomolgus macaques and analysis of virus populations."; RL Antiviral Res. 140:95-105(2017). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the filoviruses glycoprotein family. CC {ECO:0000256|ARBA:ARBA00006741}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC242800; AGB56830.1; -; Viral_cRNA. DR EMBL; KY471090; AQA27304.1; -; Viral_cRNA. DR EMBL; KY471091; AQA27313.1; -; Viral_cRNA. DR EMBL; KY471093; AQA27331.1; -; Viral_cRNA. DR EMBL; KY471094; AQA27340.1; -; Viral_cRNA. DR EMBL; KY471095; AQA27349.1; -; Viral_cRNA. DR EMBL; KY471096; AQA27358.1; -; Viral_cRNA. DR EMBL; KY471097; AQA27367.1; -; Viral_cRNA. DR EMBL; KY471098; AQA27376.1; -; Viral_cRNA. DR EMBL; KY471099; AQA27385.1; -; Viral_cRNA. DR EMBL; KY471100; AQA27394.1; -; Viral_cRNA. DR EMBL; KY471101; AQA27403.1; -; Viral_cRNA. DR EMBL; KY471102; AQA27412.1; -; Viral_cRNA. DR EMBL; KY471103; AQA27421.1; -; Viral_cRNA. DR EMBL; KY471104; AQA27430.1; -; Viral_cRNA. DR EMBL; KY471105; AQA27439.1; -; Viral_cRNA. DR EMBL; KY471106; AQA27448.1; -; Viral_cRNA. DR EMBL; KY471107; AQA27457.1; -; Viral_cRNA. DR EMBL; KY471108; AQA27466.1; -; Viral_cRNA. DR EMBL; KY471109; AQA27475.1; -; Viral_cRNA. DR EMBL; KY471110; AQA27484.1; -; Viral_cRNA. DR EMBL; KY471111; AQA27493.1; -; Viral_cRNA. DR EMBL; KY471112; AQA27502.1; -; Viral_cRNA. DR EMBL; KY471113; AQA27511.1; -; Viral_cRNA. DR EMBL; KY471114; AQA27520.1; -; Viral_cRNA. DR EMBL; KY471115; AQA27529.1; -; Viral_cRNA. DR EMBL; KY471116; AQA27538.1; -; Viral_cRNA. DR EMBL; KY471117; AQA27547.1; -; Viral_cRNA. DR EMBL; KY471118; AQA27556.1; -; Viral_cRNA. DR EMBL; KY471119; AQA27565.1; -; Viral_cRNA. DR EMBL; KY471120; AQA27574.1; -; Viral_cRNA. DR EMBL; KY471121; AQA27583.1; -; Viral_cRNA. DR EMBL; KY471122; AQA27592.1; -; Viral_cRNA. DR EMBL; KY471123; AQA27601.1; -; Viral_cRNA. DR EMBL; KY471124; AQA27610.1; -; Viral_cRNA. DR PDB; 2MB1; NMR; -; A=507-560. DR PDBsum; 2MB1; -. DR SMR; L7QI57; -. DR Proteomes; UP000144463; Genome. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR InterPro; IPR014625; GPC_FiloV. DR InterPro; IPR002561; GPC_filovir-type_extra_dom. DR Pfam; PF01611; Filo_glycop; 1. DR PIRSF; PIRSF036874; GPC_FiloV; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:2MB1}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR036874-50}; KW Lipoprotein {ECO:0000256|PIRSR:PIRSR036874-51}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Palmitate {ECO:0000256|PIRSR:PIRSR036874-51}; KW RNA editing {ECO:0000256|ARBA:ARBA00022495}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Viral envelope protein {ECO:0000313|EMBL:AQA27304.1}; KW Virion {ECO:0000313|EMBL:AQA27304.1}. FT TRANSMEM 651..675 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 15..348 FT /note="Filo_glycop" FT /evidence="ECO:0000259|Pfam:PF01611" FT REGION 314..335 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 371..476 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 314..331 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 371..397 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 401..415 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 430..470 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT LIPID 670 FT /note="S-palmitoyl cysteine; by host" FT /evidence="ECO:0000256|PIRSR:PIRSR036874-51" FT LIPID 672 FT /note="S-palmitoyl cysteine; by host" FT /evidence="ECO:0000256|PIRSR:PIRSR036874-51" FT DISULFID 53..609 FT /note="Interchain (between GP1 and GP2 chains)" FT /evidence="ECO:0000256|PIRSR:PIRSR036874-50" FT DISULFID 108..135 FT /evidence="ECO:0000256|PIRSR:PIRSR036874-50" FT DISULFID 121..147 FT /evidence="ECO:0000256|PIRSR:PIRSR036874-50" FT DISULFID 511..556 FT /evidence="ECO:0000256|PIRSR:PIRSR036874-50, FT ECO:0007829|PDB:2MB1" FT DISULFID 601..608 FT /evidence="ECO:0000256|PIRSR:PIRSR036874-50" SQ SEQUENCE 676 AA; 74482 MW; C15173F529AF4C42 CRC64; MGITGILQLP RDRFKRTSFF LWVIILFQRT FSIPLGVIHN STLQVSDVDK LVCRDKLSST NQLRSVGLNL EGNGVATDVP SATKRWGFRS GVPPKVVNYE AGEWAENCYN LEIKKPDGSE CLPAAPDGIR GFPRCRYVHK VSGTGPCAGD FAFHKEGAFF LYDRLASTVI YRGTTFAEGV VAFLILPQAK KDFFSSHPLR EPVNATEDPS SGYYSTTIRY QATGFGTNET EYLFEVDNLT YVQLESRFTP QFLLQLNETI YASGKRSNTT GKLIWKVNPE IDTTIGEWAF WETKKNLTRK IRSEELSFTA VSNGAKDISG QSPARTSSDP ETYTTTEDHK IMASENSSAM VQVHNQGREA AVSHLITLAT ISTSPQSPTT KPGQDNSTHN TPVYKLDISE ATQVEQHHRR TDNDSTASDT PPATTAAGPP KAENINTSKS ADSLDPATTT SPQNYSETAG NNNTHHQDTG EESAGSGKLG LIANTIAGVA GLITGGRRTR REAIVNAQPK CNPNLHYWTT QDEGAAIGLA WIPYFGPAAE GIYTEGLMHN QDGLICGLRQ LANETTQALQ LFLRATTELR TFSILNRKAI DFLLQRWGGT CHILGPDCCI EPHDWTKNIT DKIDQIIHDF VDKTLPDQGD NDNWWTGWRQ WIPAGIGVTG VIIAVIALFC ICKFVF //