ID L0CEG4_ECOLX Unreviewed; 158 AA. AC L0CEG4; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 29-MAY-2013, entry version 4. DE RecName: Full=Adenylosuccinate synthetase; DE EC=6.3.4.4; DE Flags: Fragment; GN Name=purA; OS Escherichia coli. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=3662, 3665, 3677, and 3697; RX PubMed=22995280; DOI=10.1016/j.meegid.2012.09.003; RA Gonzalez-Gonzalez A., Sanchez-Reyes L.L., Delgado Sapien G., RA Eguiarte L.E., Souza V.; RT "Hierarchical clustering of genetic diversity associated to different RT levels of mutation and recombination in Escherichia coli: A study RT based on Mexican isolates."; RL Infect. Genet. Evol. 13C:187-197(2012). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=3662, 3665, 3677, and 3697; RA Gonzalez A.; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Plays an important role in the de novo pathway of purine CC nucleotide biosynthesis (By similarity). CC -!- CATALYTIC ACTIVITY: GTP + IMP + L-aspartate = GDP + phosphate + CC N(6)-(1,2-dicarboxyethyl)-AMP. CC -!- PATHWAY: Purine metabolism; AMP biosynthesis via de novo pathway; CC AMP from IMP: step 1/2. CC -!- SIMILARITY: Belongs to the adenylosuccinate synthetase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ819070; AGA13695.1; -; Genomic_DNA. DR EMBL; JQ819074; AGA13699.1; -; Genomic_DNA. DR EMBL; JQ819077; AGA13702.1; -; Genomic_DNA. DR EMBL; JQ819079; AGA13704.1; -; Genomic_DNA. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0004019; F:adenylosuccinate synthase activity; IEA:InterPro. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:InterPro. DR HAMAP; MF_00011; Adenylosucc_synth; 1; -. DR InterPro; IPR018220; Adenylosuccinate_synthase_AS. DR InterPro; IPR001114; Adenylosuccinate_synthetase. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR11846; PTHR11846; 1. DR Pfam; PF00709; Adenylsucc_synt; 1. DR SMART; SM00788; Adenylsucc_synt; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS00513; ADENYLOSUCCIN_SYN_2; 1. PE 3: Inferred from homology; KW GTP-binding; Ligase; Magnesium; Metal-binding; Nucleotide-binding; KW Purine biosynthesis. FT NON_TER 1 1 FT NON_TER 158 158 SQ SEQUENCE 158 AA; 17285 MW; C4F7CC1C3092A0FD CRC64; NAREKARGAK AIGTTGRGIG PAYEDKVARR GLRVGDLFDK ETFAEKLKEV MEYHNFQLVN YYNAEAVDYQ KVLDDTMAVA DILTSMVVDV SDLLDQARQR GDFVMFEGAQ GTLLDIDHGT YPYVTSSNTT AGGVATGSGL GPRYVDYVLG ILKAYSTR //