ID K8QKI7_LACRH Unreviewed; 462 AA. AC K8QKI7; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 19-JAN-2022, entry version 43. DE SubName: Full=PTS system mannose-specific IIA/IIB/IIC component {ECO:0000313|EMBL:EKS53789.1}; DE EC=2.7.1.69 {ECO:0000313|EMBL:EKS53789.1}; GN ORFNames=LRHMDP2_30 {ECO:0000313|EMBL:EKS53789.1}; OS Lacticaseibacillus rhamnosus LRHMDP2. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; OC Lacticaseibacillus. OX NCBI_TaxID=1203258 {ECO:0000313|EMBL:EKS53789.1, ECO:0000313|Proteomes:UP000009330}; RN [1] {ECO:0000313|EMBL:EKS53789.1, ECO:0000313|Proteomes:UP000009330} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LRHMDP2 {ECO:0000313|EMBL:EKS53789.1, RC ECO:0000313|Proteomes:UP000009330}; RX PubMed=23405363; RA Chen Z., Wilkins M.R., Hunter N., Nadkarni M.A.; RT "Draft Genome Sequences of Two Clinical Isolates of Lactobacillus rhamnosus RT from Initial Stages of Dental Pulp Infection."; RL Genome Announc. 1:E00073-E00012(2013). CC -!- SUBCELLULAR LOCATION: Cell inner membrane CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004429}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EKS53789.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AMQW01000001; EKS53789.1; -; Genomic_DNA. DR EnsemblBacteria; EKS53789; EKS53789; LRHMDP2_30. DR PATRIC; fig|1203258.5.peg.29; -. DR Proteomes; UP000009330; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro. DR GO; GO:0103111; F:D-glucosamine PTS permease activity; IEA:UniProtKB-EC. DR GO; GO:0022877; F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro. DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. DR CDD; cd05569; PTS_IIB_fructose; 1. DR InterPro; IPR036095; PTS_EIIB-like_sf. DR InterPro; IPR013011; PTS_EIIB_2. DR InterPro; IPR003501; PTS_EIIB_2/3. DR InterPro; IPR003352; PTS_EIIC. DR InterPro; IPR013014; PTS_EIIC_2. DR InterPro; IPR003353; PTS_IIB_fruc. DR InterPro; IPR006327; PTS_IIC_fruc. DR Pfam; PF02378; PTS_EIIC; 1. DR Pfam; PF02302; PTS_IIB; 1. DR SUPFAM; SSF52794; SSF52794; 1. DR TIGRFAMs; TIGR01427; PTS_IIC_fructo; 1. DR PROSITE; PS51099; PTS_EIIB_TYPE_2; 1. DR PROSITE; PS51104; PTS_EIIC_TYPE_2; 1. PE 4: Predicted; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683}; KW Sugar transport {ECO:0000256|ARBA:ARBA00022597}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EKS53789.1}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 122..141 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 162..182 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 202..223 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 244..269 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 359..379 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 386..406 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 426..447 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..82 FT /note="PTS EIIB type-2" FT /evidence="ECO:0000259|PROSITE:PS51099" FT DOMAIN 111..457 FT /note="PTS EIIC type-2" FT /evidence="ECO:0000259|PROSITE:PS51104" FT REGION 87..107 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 462 AA; 47485 MW; B29FD4A6393858F6 CRC64; MAAEKLQKTG QSDGYKVKVE TQGASGTEDT LTADDIKAAD FVVLAIDVAI DGMERFVGKR VVFSTTAEAI KDPQKLIDAG KHAEVYTGEK QHGDEQETSD ADDSGHEQSP VIKQLLNGVS HMIPFVVIGG LFIALSIALG GHATAKGMVV APNTIWSTMN QIGTIGFSLM IPILAGFIAY AIAGRAALAP AMVGAMVANT PAILGTKAGT GFLGAILVGY AAGYLTKWMN SWPIPKSLRA VMPIFVIPLL GTAVICAAFV YLLGSPISWL MTALQNLLTF LSKSPSTSIV LGLVLGAMVS VDMGGPVNKV AFLFGVASIT AGTPEIMGAV ACAIAVPPLS AGIATLFKSE LTTNEEKTAG VSAILMGLIG ITEGAIPLAT AHPKQVFPGI IIGSGVASAV GMIFHITDAV PHGGPIVGVL GATNNLGLFF LAILIGVLVS TAIIVLLKQH TVAHQKKLAA AK //