ID K7YXX1_9INFA Unreviewed; 97 AA. AC K7YXX1; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 18-JAN-2017, entry version 23. DE RecName: Full=Matrix protein 2 {ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00395487}; GN Name=M2 {ECO:0000313|EMBL:AFX88542.1}; OS Influenza A virus (A/pintail/Alberta/352/1986(H6N2)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=1261960 {ECO:0000313|EMBL:AFX88542.1}; RN [1] {ECO:0000313|EMBL:AFX88542.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/pintail/Alberta/352/1986 {ECO:0000313|EMBL:AFX88542.1}; RA Wentworth D.E., Dugan V., Halpin R., Lin X., Bera J., Ghedin E., RA Fedorova N., Tsitrin T., Stockwell T., Amedeo P., Bishop B., RA Edworthy P., Gupta N., Katzel D., Li K., Schobel S., Shrivastava S., RA Thovarai V., Wang S., van Doorn R., Mai L.Q., Hang N.L., Phuong H.V., RA Cuong V.D., Thanh L., Thach N.C., Quyen P.D., Bao Y., Sanders R., RA Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.; RT "The NIAID Influenza Genome Sequencing Project."; RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AFX88542.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/pintail/Alberta/352/1986 {ECO:0000313|EMBL:AFX88542.1}; RG The NIAID Influenza Genome Sequencing Consortium; RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases. CC -!- ENZYME REGULATION: The M2 protein from most influenza A strains is CC inhibited by amantadine and rimantadine, resulting in viral CC uncoating incapacity. Emergence of amantadine-resistant variants CC is usually rapid. {ECO:0000256|RuleBase:RU361247}. CC -!- SUBUNIT: Homotetramer; composed of two disulfide-linked dimers CC held together by non-covalent interactions. May interact with CC matrix protein 1. {ECO:0000256|RuleBase:RU361247}. CC -!- SUBCELLULAR LOCATION: Host apical cell membrane CC {ECO:0000256|SAAS:SAAS00581620}; Single-pass type III membrane CC protein {ECO:0000256|SAAS:SAAS00581620}. CC -!- DOMAIN: Cytoplasmic tail plays an important role in virion CC assembly and morphogenesis. {ECO:0000256|RuleBase:RU361247}. CC -!- SIMILARITY: Belongs to the influenza viruses matrix protein M2 CC family. {ECO:0000256|RuleBase:RU361247, CC ECO:0000256|SAAS:SAAS00581646}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY126385; AFX88542.1; -; Viral_cRNA. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:InterPro. DR GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro. DR GO; GO:0039521; P:suppression by virus of host autophagy; IEA:UniProtKB-KW. DR InterPro; IPR002089; Flu_M2. DR Pfam; PF00599; Flu_M2; 1. DR ProDom; PD001031; Flu_M2; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|SAAS:SAAS00108279}; KW Host cell membrane {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108156}; KW Host membrane {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108238}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00472422}; KW Hydrogen ion transport {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108569}; KW Inhibition of host autophagy by virus {ECO:0000256|SAAS:SAAS00108142}; KW Ion channel {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108550}; KW Ion transport {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108149}; KW Membrane {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108449, ECO:0000256|SAM:Phobius}; KW Signal-anchor {ECO:0000256|RuleBase:RU361247}; KW Transmembrane {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108343, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108211, ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU361247, KW ECO:0000256|SAAS:SAAS00108321}; KW Virion {ECO:0000256|RuleBase:RU361247, ECO:0000256|SAAS:SAAS00108457}. FT TRANSMEM 26 48 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 97 AA; 11210 MW; AB3216314372F2B2 CRC64; MSLLTEVETP TRSGWECKCS DSSDPLIFAA SIIGILHLIL WILDRLFFKY IYRRLKYGLK RGPSTEGVPK SMREEYQQEQ QSAVDVDDGH FVNIELE //