ID   K7WFS5_TOXGO            Unreviewed;       371 AA.
AC   K7WFS5; S7W4N3; S8G5K4;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   29-MAY-2024, entry version 53.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN   ORFNames=TGRH88_044100 {ECO:0000313|EMBL:KAF4640484.1};
OS   Toxoplasma gondii.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX   NCBI_TaxID=5811 {ECO:0000313|EMBL:AFW99805.1};
RN   [1] {ECO:0000313|EMBL:AFW99805.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RH {ECO:0000313|EMBL:AFW99805.1};
RA   Frenal K., Mueller C., Jia Y., Soldati-Favre D.;
RT   "Characterization of putative PATs in Toxoplasma gondii.";
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KAF4640484.1, ECO:0000313|Proteomes:UP000557509}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RH-88 {ECO:0000313|EMBL:KAF4640484.1,
RC   ECO:0000313|Proteomes:UP000557509};
RA   Lorenzi H.A., Venepally P., Rozenberg A., Sibley D.;
RT   "Genome sequence of Toxoplasma gondii RH-88 strain.";
RL   Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000256|RuleBase:RU079119}.
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DR   EMBL; JX658553; AFW99805.1; -; mRNA.
DR   EMBL; JAAUHK010000195; KAF4640484.1; -; Genomic_DNA.
DR   AlphaFoldDB; K7WFS5; -.
DR   VEuPathDB; ToxoDB:TGARI_224290; -.
DR   VEuPathDB; ToxoDB:TGCAST_224290; -.
DR   VEuPathDB; ToxoDB:TGCOUG_224290; -.
DR   VEuPathDB; ToxoDB:TGDOM2_224290A; -.
DR   VEuPathDB; ToxoDB:TGDOM2_224290B; -.
DR   VEuPathDB; ToxoDB:TGFOU_224290; -.
DR   VEuPathDB; ToxoDB:TGGT1_224290; -.
DR   VEuPathDB; ToxoDB:TGMAS_224290; -.
DR   VEuPathDB; ToxoDB:TGME49_224290; -.
DR   VEuPathDB; ToxoDB:TGP89_224290A; -.
DR   VEuPathDB; ToxoDB:TGP89_224290B; -.
DR   VEuPathDB; ToxoDB:TGPRC2_224290; -.
DR   VEuPathDB; ToxoDB:TGRH88_044100; -.
DR   VEuPathDB; ToxoDB:TGRUB_224290; -.
DR   VEuPathDB; ToxoDB:TGVAND_224290; -.
DR   VEuPathDB; ToxoDB:TGVEG_224290; -.
DR   Proteomes; UP000557509; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:TreeGrafter.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006612; P:protein targeting to membrane; IEA:TreeGrafter.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   PANTHER; PTHR22883:SF43; PALMITOYLTRANSFERASE APP; 1.
DR   PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF01529; DHHC; 1.
DR   PROSITE; PS50216; DHHC; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU079119}; Membrane {ECO:0000256|RuleBase:RU079119};
KW   Transferase {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        208..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        256..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   DOMAIN          163..291
FT                   /note="Palmitoyltransferase DHHC"
FT                   /evidence="ECO:0000259|Pfam:PF01529"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..28
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   371 AA;  41503 MW;  B7DF50029314408A CRC64;
     MYNLSGADGD GVSTEDTEDS EADHLSATDD EEDLERGLLF RPESVHAAPP RPVHQSKELQ
     EEPEDAEDEE EDEEEPGLLM VTLILLVLPA VLFYPCVLPR LPEEKQVPAG WTFGLLLTGT
     LSTLIPVAFG DPGIIPREPC PTELPRGADR VKYITINGVS VPQKWCTTCY FYRPPRSKHC
     SVCNNCVRRF DHHCPWVSNC VGERNYRIFF FFLLLCVLYC LFAVAGIGVA FHTQIHSRGP
     FSFASVWTTV KACPHLALLF CYGVCCSIPV CHLLFFNIYL IVNNRTTNEE ALQLFTKKNP
     YSLGCLLNVR QFLCHRVGPS YVTPAGKART VSEKIGGLVE YCRCPSFLLP PSPRLRHSHA
     GKHHGASHRS L
//