ID K7WFS5_TOXGO Unreviewed; 371 AA. AC K7WFS5; S7W4N3; S8G5K4; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 27-MAR-2024, entry version 52. DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119}; DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119}; GN ORFNames=TGRH88_044100 {ECO:0000313|EMBL:KAF4640484.1}; OS Toxoplasma gondii. OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia; OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma. OX NCBI_TaxID=5811 {ECO:0000313|EMBL:AFW99805.1}; RN [1] {ECO:0000313|EMBL:AFW99805.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RH {ECO:0000313|EMBL:AFW99805.1}; RA Frenal K., Mueller C., Jia Y., Soldati-Favre D.; RT "Characterization of putative PATs in Toxoplasma gondii."; RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:KAF4640484.1, ECO:0000313|Proteomes:UP000557509} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RH-88 {ECO:0000313|EMBL:KAF4640484.1, RC ECO:0000313|Proteomes:UP000557509}; RA Lorenzi H.A., Venepally P., Rozenberg A., Sibley D.; RT "Genome sequence of Toxoplasma gondii RH-88 strain."; RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119}; CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004477}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity. CC {ECO:0000256|RuleBase:RU079119}. CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family. CC {ECO:0000256|RuleBase:RU079119}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JX658553; AFW99805.1; -; mRNA. DR EMBL; JAAUHK010000195; KAF4640484.1; -; Genomic_DNA. DR AlphaFoldDB; K7WFS5; -. DR VEuPathDB; ToxoDB:TGARI_224290; -. DR VEuPathDB; ToxoDB:TGCAST_224290; -. DR VEuPathDB; ToxoDB:TGCOUG_224290; -. DR VEuPathDB; ToxoDB:TGDOM2_224290A; -. DR VEuPathDB; ToxoDB:TGDOM2_224290B; -. DR VEuPathDB; ToxoDB:TGFOU_224290; -. DR VEuPathDB; ToxoDB:TGGT1_224290; -. DR VEuPathDB; ToxoDB:TGMAS_224290; -. DR VEuPathDB; ToxoDB:TGME49_224290; -. DR VEuPathDB; ToxoDB:TGP89_224290A; -. DR VEuPathDB; ToxoDB:TGP89_224290B; -. DR VEuPathDB; ToxoDB:TGPRC2_224290; -. DR VEuPathDB; ToxoDB:TGRH88_044100; -. DR VEuPathDB; ToxoDB:TGRUB_224290; -. DR VEuPathDB; ToxoDB:TGVAND_224290; -. DR VEuPathDB; ToxoDB:TGVEG_224290; -. DR Proteomes; UP000557509; Unassembled WGS sequence. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC. DR InterPro; IPR001594; Palmitoyltrfase_DHHC. DR PANTHER; PTHR22883:SF43; PALMITOYLTRANSFERASE APP; 1. DR PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1. DR Pfam; PF01529; DHHC; 1. DR PROSITE; PS50216; DHHC; 1. PE 2: Evidence at transcript level; KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315, KW ECO:0000256|RuleBase:RU079119}; Membrane {ECO:0000256|RuleBase:RU079119}; KW Transferase {ECO:0000256|RuleBase:RU079119}; KW Transmembrane {ECO:0000256|RuleBase:RU079119}; KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}. FT TRANSMEM 77..97 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU079119" FT TRANSMEM 208..235 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU079119" FT TRANSMEM 256..282 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU079119" FT DOMAIN 163..291 FT /note="Palmitoyltransferase DHHC" FT /evidence="ECO:0000259|Pfam:PF01529" FT REGION 1..75 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12..28 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 371 AA; 41503 MW; B7DF50029314408A CRC64; MYNLSGADGD GVSTEDTEDS EADHLSATDD EEDLERGLLF RPESVHAAPP RPVHQSKELQ EEPEDAEDEE EDEEEPGLLM VTLILLVLPA VLFYPCVLPR LPEEKQVPAG WTFGLLLTGT LSTLIPVAFG DPGIIPREPC PTELPRGADR VKYITINGVS VPQKWCTTCY FYRPPRSKHC SVCNNCVRRF DHHCPWVSNC VGERNYRIFF FFLLLCVLYC LFAVAGIGVA FHTQIHSRGP FSFASVWTTV KACPHLALLF CYGVCCSIPV CHLLFFNIYL IVNNRTTNEE ALQLFTKKNP YSLGCLLNVR QFLCHRVGPS YVTPAGKART VSEKIGGLVE YCRCPSFLLP PSPRLRHSHA GKHHGASHRS L //