ID K7EV64_PONAB Unreviewed; 527 AA. AC K7EV64; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 26-FEB-2020, entry version 37. DE SubName: Full=Biotinidase {ECO:0000313|Ensembl:ENSPPYP00000024444}; GN Name=BTD {ECO:0000313|Ensembl:ENSPPYP00000024444}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000024444, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000024444, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000024444} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ABGA01375095; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01375096; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01375097; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01375098; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01375099; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01375100; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01375101; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009237577.1; XM_009239302.1. DR RefSeq; XP_009237579.1; XM_009239304.1. DR RefSeq; XP_009237580.1; XM_009239305.1. DR Ensembl; ENSPPYT00000033705; ENSPPYP00000024444; ENSPPYG00000014086. DR GeneID; 100458389; -. DR CTD; 686; -. DR eggNOG; KOG0806; Eukaryota. DR eggNOG; COG0388; LUCA. DR GeneTree; ENSGT00390000013823; -. DR HOGENOM; CLU_033209_0_0_1; -. DR OrthoDB; 1276751at2759; -. DR Proteomes; UP000001595; Chromosome 3. DR GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro. DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro. DR CDD; cd07567; biotinidase_like; 1. DR Gene3D; 3.60.110.10; -; 1. DR InterPro; IPR012101; Biotinidase-like_euk. DR InterPro; IPR040154; Biotinidase/VNN. DR InterPro; IPR003010; C-N_Hydrolase. DR InterPro; IPR036526; C-N_Hydrolase_sf. DR PANTHER; PTHR10609; PTHR10609; 1. DR Pfam; PF00795; CN_hydrolase; 1. DR PIRSF; PIRSF011861; Biotinidase; 1. DR SUPFAM; SSF56317; SSF56317; 1. DR PROSITE; PS50263; CN_HYDROLASE; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..25 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 26..527 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003900980" FT DOMAIN 56..335 FT /note="CN hydrolase" FT /evidence="ECO:0000259|PROSITE:PS50263" FT COILED 60..87 FT /evidence="ECO:0000256|SAM:Coils" FT ACT_SITE 96 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR011861-1" FT ACT_SITE 196 FT /note="Proton donor" FT /evidence="ECO:0000256|PIRSR:PIRSR011861-1" FT ACT_SITE 229 FT /note="Nucleophile" FT /evidence="ECO:0000256|PIRSR:PIRSR011861-1" SQ SEQUENCE 527 AA; 59392 MW; 46C6C761968FC948 CRC64; MVCIMSGARS KLALFLCGCY VVALGAHTGE ESVAEHHEAE YYMAAVYEHP SILSLNPLAL VSRQEALELM NQNLDIYEQQ VMTAAQKGVQ IIVFPEDGIH GFNFTRTSIY PFLDFMPSPQ VVRWNPCLEP HRFSDTEVLQ RLSCMAIRGD MFLVANLGTK QPCHSSDPRC PKDGRYQFNT NVVFSNNGTL VDRYRKHNLY FEAAFDVPLK VDHITFDTPF AGRFGIFTCF DILFFDPTIR LLRDYKVKHV VYPTAWMNQL PLLAAIEIQK AFAVAFGINV LAANVHHPVL GMTGSGIHTP LESFWYHDME NPKSHLIIAQ VAKNPVGLIG AENATGETDP SHSKFLKILS GDPYCEKDAQ EVHCDEATQW NVNAPPTFHS EMMYDNFTLV PVWGKEGYLH VCSNGFCCYL LYKRPSLSKE LYALGVFNGL HTVHGTYYIQ VCALVRCGGL GFDTCGQEIT EATGIFEFHL WGNFSTSYIF PLFLTSGMTL EVPDQLGWEN DHYFLRKSRL SSGLVTAALY GRLYERD //