ID K7ENW7_HUMAN Unreviewed; 389 AA. AC K7ENW7; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 12-SEP-2018, entry version 36. DE SubName: Full=DNA (cytosine-5)-methyltransferase 1 {ECO:0000313|Ensembl:ENSP00000467125}; DE Flags: Fragment; GN Name=DNMT1 {ECO:0000313|Ensembl:ENSP00000467125}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467125, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000467125, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000467125} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the class I-like SAM-binding CC methyltransferase superfamily. C5-methyltransferase family. CC {ECO:0000256|PROSITE-ProRule:PRU01016}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC010077; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC011511; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC020931; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7ENW7; -. DR MaxQB; K7ENW7; -. DR PeptideAtlas; K7ENW7; -. DR PRIDE; K7ENW7; -. DR Ensembl; ENST00000588913; ENSP00000467125; ENSG00000130816. DR UCSC; uc060teu.1; human. DR EuPathDB; HostDB:ENSG00000130816.14; -. DR HGNC; HGNC:2976; DNMT1. DR OpenTargets; ENSG00000130816; -. DR eggNOG; ENOG410IF68; Eukaryota. DR eggNOG; COG0270; LUCA. DR GeneTree; ENSGT00390000005100; -. DR ChiTaRS; DNMT1; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000130816; Expressed in 215 organ(s), highest expression level in oocyte. DR ExpressionAtlas; K7ENW7; baseline and differential. DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW. DR InterPro; IPR001525; C5_MeTfrase. DR InterPro; IPR029063; SAM-dependent_MTases. DR Pfam; PF00145; DNA_methylase; 1. DR PRINTS; PR00105; C5METTRFRASE. DR SUPFAM; SSF53335; SSF53335; 2. DR PROSITE; PS51679; SAM_MT_C5; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01016}; KW Proteomics identification {ECO:0000213|EPD:K7ENW7, KW ECO:0000213|MaxQB:K7ENW7, ECO:0000213|PeptideAtlas:K7ENW7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01016}; KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01016}. FT ACT_SITE 2 2 {ECO:0000256|PROSITE-ProRule:PRU01016}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000467125}. SQ SEQUENCE 389 AA; 43389 MW; 00CD4BB3D6A2C2F6 CRC64; XCQGFSGMNR FNSRTYSKFK NSLVVSFLSY CDYYRPRFFL LENVRNFVSF KRSMVLKLTL RCLVRMGYQC TFGVLQAGQY GVAQTRRRAI ILAAAPGEKL PLFPEPLHVF APRACQLSVV VDDKKFVSNI TRLSSGPFRT ITVRDTMSDL PEVRNGASAL EISYNGEPQS WFQRQLRGAQ YQPILRDHIC KDMSALVAAR MRHIPLAPGS DWRDLPNIEV RLSDGTMARK LRYTHHDRKN GRSSSGALRG VCSCVEAGKA CDPAARQFNT LIPWCLPHTG NRHNHWAGLY GRLEWDGFFS TTVTNPEPMG KQGRVLHPEQ HRVVSVRECA RSQGFPDTYR LFGNILDKHR QVSGAAPAGS GQEGGFCACH QVGLGPAQSL PGGRLLAAG //