ID K7ENW7_HUMAN Unreviewed; 389 AA. AC K7ENW7; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 05-OCT-2016, entry version 21. DE SubName: Full=DNA (cytosine-5)-methyltransferase 1 {ECO:0000313|Ensembl:ENSP00000467125}; DE Flags: Fragment; GN Name=DNMT1 {ECO:0000313|Ensembl:ENSP00000467125}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467125, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000467125, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000467125} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSP00000467125}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC010077; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC011511; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC020931; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7ENW7; -. DR STRING; 9606.ENSP00000352516; -. DR MaxQB; K7ENW7; -. DR PaxDb; K7ENW7; -. DR PeptideAtlas; K7ENW7; -. DR PRIDE; K7ENW7; -. DR Ensembl; ENST00000588913; ENSP00000467125; ENSG00000130816. DR UCSC; uc060teu.1; human. DR HGNC; HGNC:2976; DNMT1. DR eggNOG; ENOG410IF68; Eukaryota. DR eggNOG; COG0270; LUCA. DR GeneTree; ENSGT00390000005100; -. DR OMA; RECARTQ; -. DR ChiTaRS; DNMT1; human. DR Proteomes; UP000005640; Chromosome 19. DR ExpressionAtlas; K7ENW7; baseline and differential. DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro. DR InterPro; IPR001525; C5_MeTfrase. DR InterPro; IPR029063; SAM-dependent_MTases. DR Pfam; PF00145; DNA_methylase; 1. DR PRINTS; PR00105; C5METTRFRASE. DR SUPFAM; SSF53335; SSF53335; 2. DR PROSITE; PS51679; SAM_MT_C5; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:K7ENW7, KW ECO:0000213|MaxQB:K7ENW7, ECO:0000213|PeptideAtlas:K7ENW7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 2 354 SAM-dependent_MTases. {ECO:0000259|Pfam: FT PF00145}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000467125}. SQ SEQUENCE 389 AA; 43389 MW; 00CD4BB3D6A2C2F6 CRC64; XCQGFSGMNR FNSRTYSKFK NSLVVSFLSY CDYYRPRFFL LENVRNFVSF KRSMVLKLTL RCLVRMGYQC TFGVLQAGQY GVAQTRRRAI ILAAAPGEKL PLFPEPLHVF APRACQLSVV VDDKKFVSNI TRLSSGPFRT ITVRDTMSDL PEVRNGASAL EISYNGEPQS WFQRQLRGAQ YQPILRDHIC KDMSALVAAR MRHIPLAPGS DWRDLPNIEV RLSDGTMARK LRYTHHDRKN GRSSSGALRG VCSCVEAGKA CDPAARQFNT LIPWCLPHTG NRHNHWAGLY GRLEWDGFFS TTVTNPEPMG KQGRVLHPEQ HRVVSVRECA RSQGFPDTYR LFGNILDKHR QVSGAAPAGS GQEGGFCACH QVGLGPAQSL PGGRLLAAG //