ID K7EN02_HUMAN Unreviewed; 185 AA. AC K7EN02; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 29-MAY-2024, entry version 62. DE RecName: Full=Troponin I, cardiac muscle {ECO:0000256|ARBA:ARBA00018910}; GN Name=TNNI3 {ECO:0000313|Ensembl:ENSP00000466729.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466729.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000466729.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000466729.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2024) to UniProtKB. CC -!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin CC filament regulatory complex which confers calcium-sensitivity to CC striated muscle actomyosin ATPase activity. CC {ECO:0000256|ARBA:ARBA00001988}. CC -!- SIMILARITY: Belongs to the troponin I family. CC {ECO:0000256|ARBA:ARBA00009930}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC010327; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF459707; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; K7EN02; -. DR SMR; K7EN02; -. DR IntAct; K7EN02; 1. DR MassIVE; K7EN02; -. DR PeptideAtlas; K7EN02; -. DR Antibodypedia; 4354; 2810 antibodies from 52 providers. DR Ensembl; ENST00000588882.1; ENSP00000466729.1; ENSG00000129991.13. DR UCSC; uc061cxc.1; human. DR HGNC; HGNC:11947; TNNI3. DR VEuPathDB; HostDB:ENSG00000129991; -. DR GeneTree; ENSGT01030000234588; -. DR HOGENOM; CLU_098686_1_0_1; -. DR ChiTaRS; TNNI3; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000129991; Expressed in apex of heart and 101 other cell types or tissues. DR ExpressionAtlas; K7EN02; baseline and differential. DR GO; GO:0005861; C:troponin complex; IEA:InterPro. DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW. DR GO; GO:0060048; P:cardiac muscle contraction; IEA:TreeGrafter. DR GO; GO:0003009; P:skeletal muscle contraction; IEA:TreeGrafter. DR Gene3D; 1.20.5.350; -; 1. DR Gene3D; 6.10.250.180; -; 1. DR InterPro; IPR001978; Troponin. DR InterPro; IPR038077; Troponin_sf. DR PANTHER; PTHR13738; TROPONIN I; 1. DR PANTHER; PTHR13738:SF2; TROPONIN I, CARDIAC MUSCLE; 1. DR Pfam; PF00992; Troponin; 1. DR SUPFAM; SSF90250; Troponin coil-coiled subunits; 1. PE 1: Evidence at protein level; KW Actin-binding {ECO:0000256|ARBA:ARBA00023203}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Muscle protein {ECO:0000256|ARBA:ARBA00023179}; KW Proteomics identification {ECO:0007829|MaxQB:K7EN02, KW ECO:0007829|PeptideAtlas:K7EN02}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT COILED 24..85 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 185 AA; 21328 MW; D5E86E3AC136DB49 CRC64; MILPCSISPW QKKSKISASR KLQLKTLLLQ IAKQELEREA EERRGEKGRA LSTRCQPLEL AGLGFAELQD LCRQLHARVD KVDEERYDIE AKVTKNITEI ADLTQKIFDL RGKFKRPTLR RVRISADAMM QALLGARAKE SLDLRAHLKQ VKKEDTEKEN REVGDWRKNI DALSGMEGRK KKFES //