ID K7EN02_HUMAN Unreviewed; 185 AA. AC K7EN02; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 19-JAN-2022, entry version 50. DE SubName: Full=Troponin I, cardiac muscle {ECO:0000313|Ensembl:ENSP00000466729}; GN Name=TNNI3 {ECO:0000313|Ensembl:ENSP00000466729}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466729, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000466729, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000466729} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC010327; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF459707; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; K7EN02; -. DR IntAct; K7EN02; 1. DR PeptideAtlas; K7EN02; -. DR PRIDE; K7EN02; -. DR Antibodypedia; 4354; 2565 antibodies from 51 providers. DR Ensembl; ENST00000588882; ENSP00000466729; ENSG00000129991. DR UCSC; uc061cxc.1; human. DR HGNC; HGNC:11947; TNNI3. DR OpenTargets; ENSG00000129991; -. DR VEuPathDB; HostDB:ENSG00000129991; -. DR GeneTree; ENSGT01030000234588; -. DR HOGENOM; CLU_098686_1_0_1; -. DR ChiTaRS; TNNI3; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000129991; Expressed in apex of heart and 127 other tissues. DR ExpressionAtlas; K7EN02; baseline and differential. DR GO; GO:0005861; C:troponin complex; IEA:InterPro. DR GO; GO:0030049; P:muscle filament sliding; IEA:UniProt. DR Gene3D; 1.20.5.350; -; 1. DR InterPro; IPR001978; Troponin. DR InterPro; IPR038077; Troponin_sf. DR Pfam; PF00992; Troponin; 1. DR SUPFAM; SSF90250; SSF90250; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Muscle protein {ECO:0000256|ARBA:ARBA00023179}; KW Proteomics identification {ECO:0007829|MaxQB:K7EN02, KW ECO:0007829|PeptideAtlas:K7EN02}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT COILED 24..49 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 65..85 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 185 AA; 21328 MW; D5E86E3AC136DB49 CRC64; MILPCSISPW QKKSKISASR KLQLKTLLLQ IAKQELEREA EERRGEKGRA LSTRCQPLEL AGLGFAELQD LCRQLHARVD KVDEERYDIE AKVTKNITEI ADLTQKIFDL RGKFKRPTLR RVRISADAMM QALLGARAKE SLDLRAHLKQ VKKEDTEKEN REVGDWRKNI DALSGMEGRK KKFES //