ID K7EMT4_HUMAN Unreviewed; 169 AA. AC K7EMT4; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 25-MAY-2022, entry version 39. DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 {ECO:0000256|ARBA:ARBA00018191}; DE AltName: Full=Complex I-B14.7 {ECO:0000256|ARBA:ARBA00030608}; DE AltName: Full=NADH-ubiquinone oxidoreductase subunit B14.7 {ECO:0000256|ARBA:ARBA00031497}; DE Flags: Fragment; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466639, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000466639, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000466639} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I), that is believed not to be CC involved in catalysis. Complex I functions in the transfer of electrons CC from NADH to the respiratory chain. The immediate electron acceptor for CC the enzyme is believed to be ubiquinone. CC {ECO:0000256|ARBA:ARBA00003195}. CC -!- SUBUNIT: Complex I is composed of 45 different subunits. CC {ECO:0000256|ARBA:ARBA00011533}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|ARBA:ARBA00004292}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004292}; Matrix side CC {ECO:0000256|ARBA:ARBA00004292}. CC -!- SIMILARITY: Belongs to the complex I NDUFA11 subunit family. CC {ECO:0000256|ARBA:ARBA00008699}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC024592; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC104532; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9606.ENSP00000466639; -. DR BioMuta; ENSG00000267740; -. DR MaxQB; K7EMT4; -. DR PaxDb; K7EMT4; -. DR PeptideAtlas; K7EMT4; -. DR Ensembl; ENST00000586349.5; ENSP00000466639.1; ENSG00000267740.5. DR UCSC; uc060sel.1; human. DR GeneCards; ENSG00000267740; -. DR VEuPathDB; HostDB:ENSG00000267740; -. DR eggNOG; ENOG502S6F6; Eukaryota. DR GeneTree; ENSGT00390000012434; -. DR InParanoid; K7EMT4; -. DR PhylomeDB; K7EMT4; -. DR TreeFam; TF314729; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; K7EMT4; protein. DR Bgee; ENSG00000267740; Expressed in sural nerve and 113 other tissues. DR ExpressionAtlas; K7EMT4; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005739; C:mitochondrion; IDA:HPA. DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:InterPro. DR InterPro; IPR039205; NDUFA11. DR PANTHER; PTHR21382; PTHR21382; 2. PE 3: Inferred from homology; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128}; KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}; KW Transport {ECO:0000256|ARBA:ARBA00022448}. FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000466639" FT NON_TER 169 FT /evidence="ECO:0000313|Ensembl:ENSP00000466639" SQ SEQUENCE 169 AA; 17270 MW; F69787580F18BCAE CRC64; XPKVFRQYWD IPDGTDCHRK AYSTTSIASV AGLTAAAYRV TLNPPGTFLE GVAKVGQYTF TADTGSERPR GSCCARLEAL ALPVYPAAAV GAVFGLTTCI SAHVREKPDD PLNYFLGGCA GGLTLGARTT LTHGSPGPSQ ATVAVAPLSG RAAVSAAGGC VFLLLPACV //