ID   K7EKM3_HUMAN            Unreviewed;       147 AA.
AC   K7EKM3;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 2.
DT   29-SEP-2021, entry version 43.
DE   SubName: Full=Troponin T, slow skeletal muscle {ECO:0000313|Ensembl:ENSP00000465686};
DE   Flags: Fragment;
GN   Name=TNNT1 {ECO:0000313|Ensembl:ENSP00000465686};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000465686, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000465686, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000465686}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC       the thin filament regulatory complex which confers calcium-sensitivity
CC       to striated muscle actomyosin ATPase activity.
CC       {ECO:0000256|ARBA:ARBA00003363}.
CC   -!- SIMILARITY: Belongs to the troponin T family.
CC       {ECO:0000256|ARBA:ARBA00008330}.
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DR   EMBL; AC010327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; K7EKM3; -.
DR   Antibodypedia; 4195; 273 antibodies.
DR   Ensembl; ENST00000589745; ENSP00000465686; ENSG00000105048.
DR   UCSC; uc061cwp.1; human.
DR   HGNC; HGNC:11948; TNNT1.
DR   OpenTargets; ENSG00000105048; -.
DR   VEuPathDB; HostDB:ENSG00000105048; -.
DR   GeneTree; ENSGT00940000160609; -.
DR   ChiTaRS; TNNT1; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000105048; Expressed in muscle organ and 157 other tissues.
DR   ExpressionAtlas; K7EKM3; baseline and differential.
DR   GO; GO:0005861; C:troponin complex; IEA:InterPro.
DR   GO; GO:0006937; P:regulation of muscle contraction; IEA:InterPro.
DR   Gene3D; 1.20.5.350; -; 1.
DR   InterPro; IPR027707; TNNT.
DR   InterPro; IPR001978; Troponin.
DR   InterPro; IPR038077; Troponin_sf.
DR   PANTHER; PTHR11521; PTHR11521; 1.
DR   Pfam; PF00992; Troponin; 2.
DR   SUPFAM; SSF90250; SSF90250; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW   Proteomics identification {ECO:0007829|MaxQB:K7EKM3,
KW   ECO:0007829|PeptideAtlas:K7EKM3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          85..105
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000465686"
SQ   SEQUENCE   147 AA;  17429 MW;  C23A1C4D9E69941E CRC64;
     XRTEKERERQ AKLAEEKMRK EEEEAKKRAE DDAKKKKVLS NMGAHFGGYL VKAEQKRGKR
     QTGREMKVRI LSERKKPLDI DYMGEEQLRE KAQELSDWIH QLESEKFDLM AKLKQQKYEI
     NVLYNRISHA QKFRKGAGKG RVGGRWK
//