ID K7DT13_PANTR Unreviewed; 1155 AA. AC K7DT13; A0A2J8PA75; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 24-JAN-2024, entry version 62. DE RecName: Full=ATP-dependent RNA helicase DHX30 {ECO:0000256|ARBA:ARBA00039388}; DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552}; DE AltName: Full=DEAH box protein 30 {ECO:0000256|ARBA:ARBA00042917}; GN Name=DHX30 {ECO:0000313|EMBL:JAA42467.1, GN ECO:0000313|Ensembl:ENSPTRP00000071677.1, ECO:0000313|VGNC:VGNC:7968}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Pan. OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA42467.1}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000071677.1, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the human RT genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|EMBL:JAA42467.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA04141.1}, Skeletal muscle RC {ECO:0000313|EMBL:JAA42467.1}, Skin {ECO:0000313|EMBL:JAA24032.1}, and RC Smooth vascular {ECO:0000313|EMBL:JAA17169.1}; RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.; RT "De novo assembly of the reference chimpanzee transcriptome from NextGen RT mRNA sequences."; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPTRP00000071677.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2023) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; CC Evidence={ECO:0000256|ARBA:ARBA00001556}; CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid CC {ECO:0000256|ARBA:ARBA00004436}. CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily. CC {ECO:0000256|ARBA:ARBA00008792}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AACZ04000305; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; GABC01007197; JAA04141.1; -; mRNA. DR EMBL; GABF01004976; JAA17169.1; -; mRNA. DR EMBL; GABD01009068; JAA24032.1; -; mRNA. DR EMBL; GABE01002272; JAA42467.1; -; mRNA. DR RefSeq; XP_016796499.1; XM_016941010.1. DR SMR; K7DT13; -. DR Ensembl; ENSPTRT00000091857.1; ENSPTRP00000071677.1; ENSPTRG00000014877.5. DR VGNC; VGNC:7968; DHX30. DR GeneTree; ENSGT00940000158279; -. DR OMA; QYSCTEH; -. DR OrthoDB; 1095660at2759; -. DR Proteomes; UP000002277; Chromosome 3. DR Bgee; ENSPTRG00000014877; Expressed in dorsolateral prefrontal cortex and 20 other cell types or tissues. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC. DR CDD; cd17976; DEXHc_DHX30; 1. DR CDD; cd18791; SF2_C_RHA; 1. DR Gene3D; 1.20.120.1080; -; 1. DR Gene3D; 3.30.160.20; -; 2. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR InterPro; IPR011709; DEAD-box_helicase_OB_fold. DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom. DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS. DR InterPro; IPR007502; Helicase-assoc_dom. DR InterPro; IPR014001; Helicase_ATP-bd. DR InterPro; IPR001650; Helicase_C. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1. DR PANTHER; PTHR18934:SF257; ATP-DEPENDENT RNA HELICASE DHX30; 1. DR Pfam; PF00270; DEAD; 1. DR Pfam; PF21010; HA2_C; 1. DR Pfam; PF00271; Helicase_C; 1. DR Pfam; PF07717; OB_NTP_bind; 1. DR SMART; SM00487; DEXDc; 1. DR SMART; SM00847; HA2; 1. DR SMART; SM00490; HELICc; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1. DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1. DR PROSITE; PS51194; HELICASE_CTER; 1. PE 2: Evidence at transcript level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023271}; KW Mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00023271}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}. FT DOMAIN 405..573 FT /note="Helicase ATP-binding" FT /evidence="ECO:0000259|PROSITE:PS51192" FT DOMAIN 615..788 FT /note="Helicase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51194" FT REGION 111..160 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1155 AA; 129438 MW; D3417B4C609F6360 CRC64; MAASRDLLKE FPQPKNLLNS VIGRALGISH AKDKLVYVHT NGPKKKKVTL HIKWPKSVEV EGYGSKKIDA ERQAAAAACQ LFKGWGLLGP RNELFDAAKY RVLADRFGSP ADSWWRPEPT MPPTSWRQLN PESIRPGGPG GLSRSLGREE EEDEEEELEE GTIDVTDFLS MTQQDSHAPL RDSRGSSFEM TDDDSAIRAL TQFPLPKNLL AKVIQIATSS STAKNLMQFH TVGTKTKLST LTLLWPCPMT FVAKGRRKAE AENKAAALAC KKLKSLGLVD RNNEPLTHAM YNLASLRELG ETQRRPCTIQ VPEPILRKIE TFLNHYPVES SWIAPELRLQ SDDILPLGKD SGPLSDPITG KPYVPLLEAE EVRLSQSLLE LWRRRGPVWQ EAPQLPVDPH RDTILNAIEQ HPVVVISGDT GCGKTTRIPQ LLLERYVTEG RGARCNVIIT QPRRISAVSV AQRVSHELGP SLRRNVGFQV RLESKPPSRG GALLFCTVGI LLRKLQSNPS LEGVSHVIVD EVHERDVNTD FLLILLKGLQ RLNPALRLVL MSATGDNERF SRYFGGCPVI KVPGFMYPVK EHYLEDILAK LGKHQYLHRH RHHESEDECA LDLDLVTDLV LHIDARGEPG GILCFLPGWQ EIKGVQQRLQ EALGMHESKY LILPVHSNIP MMDQKAIFQQ PPVGVRKIVL ATNIAETSIT INDIVHVVDS GLHKEERYDL KTKVSCLETV WVSRANVIQR RGRAGRCQSG FAYHLFPRSR LEKMVPFQVP EILRTPLENL VLQAKIHMPE KTAVEFLSKA VDSPNIKAVD EAVILLQEIG VLDQREYLTT LGQRLAHIST DPRLAKAIVL AAIFRCLHPL LVVVSCLTRD PFSSSLQNRA EVDKVKALLS HDSGSDHLAF VRAVAGWEEV LRWQDRSSRE NYLEENLLYA PSLRFIHGLI KQFSENIYEA FLVGKPSDCT LASAQCNEYS EEEELVKGVL MAGLYPNLIQ VRQGKVTRQG KFKPNSVTYR TKSGNILLHK STINREATRL RSRWLTYFMA VKSNGSVFVR DSSQVHPLAV LLLTDGDVHI RDDGRRATIS LSDSDLLRLE GDSRTVRLLK ELRRALGRMV ERSLRSELAA LPPSVQEEHG QLLALLAELL RGPCGSFDVR KTADD //