ID K7A240_9ALTE Unreviewed; 200 AA. AC K7A240; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 29-MAY-2013, entry version 6. DE RecName: Full=Non-canonical purine NTP pyrophosphatase; DE EC=3.6.1.19; DE AltName: Full=Non-standard purine NTP pyrophosphatase; DE AltName: Full=Nucleoside-triphosphate diphosphatase; DE AltName: Full=Nucleoside-triphosphate pyrophosphatase; GN Name=mazG; ORFNames=GPLA_4129; OS Glaciecola polaris LMG 21857. OC Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales; OC Alteromonadaceae; Glaciecola. OX NCBI_TaxID=1129793; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=LMG 21857; RA Qin Q.L., Xie B.B., Shu Y.L., Zhang Y.Z.; RT "Genome Sequencing of Glaciecola polaris LMG 21857."; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Pyrophosphatase that hydrolyzes non-canonical purine CC nucleotides such as XTP and ITP/dITP to their respective CC monophosphate derivatives. Might exclude non-canonical purines CC from DNA precursor pool, thus preventing their incorporation into CC DNA and avoiding chromosomal lesions (By similarity). CC -!- CATALYTIC ACTIVITY: A nucleoside triphosphate + H(2)O = a CC nucleotide + diphosphate. CC -!- COFACTOR: Binds 1 divalent metal cation ion per subunit; can use CC either magnesium or manganese (By similarity). CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SIMILARITY: Belongs to the HAM1 NTPase family. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BAER01000124; GAC35008.1; -; Genomic_DNA. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. DR GO; GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IEA:HAMAP. DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. DR GO; GO:0009143; P:nucleoside triphosphate catabolic process; IEA:InterPro. DR GO; GO:0006163; P:purine nucleotide metabolic process; IEA:HAMAP. DR HAMAP; MF_01405; Non_canon_purine_NTPase; 1; -. DR InterPro; IPR002637; Ham1p-like. DR InterPro; IPR020922; NTPase. DR PANTHER; PTHR11067; PTHR11067; 1. DR Pfam; PF01725; Ham1p_like; 1. DR TIGRFAMs; TIGR00042; TIGR00042; 1. PE 3: Inferred from homology; KW Hydrolase; Magnesium; Manganese; Metal-binding; Nucleotide metabolism; KW Nucleotide-binding. FT REGION 9 14 Substrate binding (By similarity). FT REGION 70 71 Substrate binding (By similarity). FT METAL 70 70 Magnesium or manganese (By similarity). FT BINDING 158 158 Substrate (By similarity). FT BINDING 178 178 Substrate (By similarity). FT BINDING 184 184 Substrate (By similarity). SQ SEQUENCE 200 AA; 21492 MW; D7D7964716B6A2AE CRC64; MSRKIVLATG NKGKVAELSQ LLSPLDIDIV PQSEFNVPDV AETGTTFVEN AIIKARHAAK ITGLPAIADD SGLAVDALDG APGVYSARYA GSHATDTDNI DKLLEALKDV APAARHARFL CVLVYMRSAD DPTPIICQGE WHGKITTQRT GDSGFGYDPV FWVEQKQCTS AQLSKEQKNA LSHRGQALDQ LLITLSADFD //