ID K2GAG9_ENTNP Unreviewed; 243 AA. AC K2GAG9; DT 28-NOV-2012, integrated into UniProtKB/TrEMBL. DT 28-NOV-2012, sequence version 1. DT 29-MAY-2024, entry version 40. DE RecName: Full=Derlin {ECO:0000256|RuleBase:RU363059}; GN ORFNames=ENU1_125150 {ECO:0000313|EMBL:EKE39511.1}; OS Entamoeba nuttalli (strain P19) (Amoeba). OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae; OC Entamoeba. OX NCBI_TaxID=1076696 {ECO:0000313|EMBL:EKE39511.1, ECO:0000313|Proteomes:UP000006769}; RN [1] {ECO:0000313|EMBL:EKE39511.1, ECO:0000313|Proteomes:UP000006769} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=P19 {ECO:0000313|EMBL:EKE39511.1, RC ECO:0000313|Proteomes:UP000006769}; RA Hannick L., Karamycheva S., Lorenzi H., Caler E.; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May be involved in the degradation of misfolded endoplasmic CC reticulum (ER) luminal proteins. {ECO:0000256|RuleBase:RU363059}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363059}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477, CC ECO:0000256|RuleBase:RU363059}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the derlin family. CC {ECO:0000256|ARBA:ARBA00008917, ECO:0000256|RuleBase:RU363059}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JH927512; EKE39511.1; -; Genomic_DNA. DR RefSeq; XP_008858158.1; XM_008859936.1. DR AlphaFoldDB; K2GAG9; -. DR EnsemblProtists; EKE39511; EKE39511; ENU1_125150. DR GeneID; 20074335; -. DR VEuPathDB; AmoebaDB:ENU1_125150; -. DR OMA; MSRIFND; -. DR OrthoDB; 23521at2759; -. DR Proteomes; UP000006769; Unassembled WGS sequence. DR GO; GO:0000839; C:Hrd1p ubiquitin ligase ERAD-L complex; IEA:TreeGrafter. DR GO; GO:0051787; F:misfolded protein binding; IEA:TreeGrafter. DR GO; GO:1990381; F:ubiquitin-specific protease binding; IEA:TreeGrafter. DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:TreeGrafter. DR InterPro; IPR007599; DER1. DR InterPro; IPR035952; Rhomboid-like_sf. DR PANTHER; PTHR11009; DER1-LIKE PROTEIN, DERLIN; 1. DR PANTHER; PTHR11009:SF32; DERLIN; 1. DR Pfam; PF04511; DER1; 1. DR SUPFAM; SSF144091; Rhomboid-like; 1. PE 3: Inferred from homology; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, KW ECO:0000256|RuleBase:RU363059}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363059}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU363059}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU363059}. FT TRANSMEM 6..28 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363059" FT TRANSMEM 92..113 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363059" FT TRANSMEM 119..135 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363059" FT TRANSMEM 147..170 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363059" FT TRANSMEM 176..196 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363059" SQ SEQUENCE 243 AA; 28985 MW; 1296D845F8E9887C CRC64; MEILNVFAGY PIITRTILIM IISLFVLMKV RIIHISQLSF DVDAILSGEI WRLVTPFLVY SDRFSIWFIF ELLFISQALS QIEQTYRSWL HCLWVIFIGC SGILVLSFTF HFIDYVPGQL PLLFNSFSNF IIYLWSKQNR EQRVAMFFIF VIPLVYFPWI SLFLHVSFIS EAINDIYGIF IGHVVYWLET VFPMYYNWKP LELPKFLYDL FIHPIHLEEE QNPNIELNEE NQIEGQQLNE NDE //