ID K2GAG9_ENTNP Unreviewed; 243 AA. AC K2GAG9; DT 28-NOV-2012, integrated into UniProtKB/TrEMBL. DT 28-NOV-2012, sequence version 1. DT 16-OCT-2019, entry version 24. DE RecName: Full=Derlin {ECO:0000256|RuleBase:RU363059}; GN ORFNames=ENU1_125150 {ECO:0000313|EMBL:EKE39511.1}; OS Entamoeba nuttalli (strain P19) (Amoeba). OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Entamoebidae; Entamoeba. OX NCBI_TaxID=1076696 {ECO:0000313|EMBL:EKE39511.1}; RN [1] {ECO:0000313|EMBL:EKE39511.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=P19 {ECO:0000313|EMBL:EKE39511.1}; RA Hannick L., Karamycheva S., Lorenzi H., Caler E.; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May be involved in the degradation of misfolded CC endoplasmic reticulum (ER) luminal proteins. CC {ECO:0000256|RuleBase:RU363059}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|RuleBase:RU363059}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU363059}. CC -!- SIMILARITY: Belongs to the derlin family. CC {ECO:0000256|RuleBase:RU363059}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JH927512; EKE39511.1; -; Genomic_DNA. DR RefSeq; XP_008858158.1; XM_008859936.1. DR EnsemblProtists; EKE39511; EKE39511; ENU1_125150. DR GeneID; 20074335; -. DR EuPathDB; AmoebaDB:ENU1_125150; -. DR OMA; KYFQVWR; -. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR InterPro; IPR007599; DER1. DR Pfam; PF04511; DER1; 1. PE 3: Inferred from homology; KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU363059}; KW Membrane {ECO:0000256|RuleBase:RU363059}; KW Transmembrane {ECO:0000256|RuleBase:RU363059}; KW Transmembrane helix {ECO:0000256|RuleBase:RU363059}. FT TRANSMEM 6 28 Helical. {ECO:0000256|RuleBase:RU363059}. FT TRANSMEM 92 113 Helical. {ECO:0000256|RuleBase:RU363059}. FT TRANSMEM 119 135 Helical. {ECO:0000256|RuleBase:RU363059}. FT TRANSMEM 147 170 Helical. {ECO:0000256|RuleBase:RU363059}. FT TRANSMEM 176 196 Helical. {ECO:0000256|RuleBase:RU363059}. SQ SEQUENCE 243 AA; 28985 MW; 1296D845F8E9887C CRC64; MEILNVFAGY PIITRTILIM IISLFVLMKV RIIHISQLSF DVDAILSGEI WRLVTPFLVY SDRFSIWFIF ELLFISQALS QIEQTYRSWL HCLWVIFIGC SGILVLSFTF HFIDYVPGQL PLLFNSFSNF IIYLWSKQNR EQRVAMFFIF VIPLVYFPWI SLFLHVSFIS EAINDIYGIF IGHVVYWLET VFPMYYNWKP LELPKFLYDL FIHPIHLEEE QNPNIELNEE NQIEGQQLNE NDE //