ID K1VKE6_TRIAC Unreviewed; 788 AA. AC K1VKE6; DT 28-NOV-2012, integrated into UniProtKB/TrEMBL. DT 28-NOV-2012, sequence version 1. DT 07-SEP-2016, entry version 30. DE RecName: Full=E3 ubiquitin-protein ligase {ECO:0000256|PIRNR:PIRNR001569}; DE EC=6.3.2.- {ECO:0000256|PIRNR:PIRNR001569}; GN ORFNames=A1Q2_06060 {ECO:0000313|EMBL:EKC99641.1}; OS Trichosporon asahii var. asahii (strain CBS 8904) (Yeast). OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; OC Tremellomycetes; Trichosporonales; Trichosporonaceae; Trichosporon. OX NCBI_TaxID=1220162 {ECO:0000313|EMBL:EKC99641.1, ECO:0000313|Proteomes:UP000006757}; RN [1] {ECO:0000313|EMBL:EKC99641.1, ECO:0000313|Proteomes:UP000006757} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CBS 8904 {ECO:0000313|EMBL:EKC99641.1, RC ECO:0000313|Proteomes:UP000006757}; RX PubMed=23193141; DOI=10.1128/EC.00264-12; RA Yang R.Y., Li H.T., Zhu H., Zhou G.P., Wang M., Wang L.; RT "Genome sequence of the Trichosporon asahii environmental strain CBS RT 8904."; RL Eukaryot. Cell 11:1586-1587(2012). CC -!- PATHWAY: Protein modification; protein ubiquitination. CC {ECO:0000256|PIRNR:PIRNR001569}. CC -!- SIMILARITY: Contains HECT (E6AP-type E3 ubiquitin-protein ligase) CC domain. {ECO:0000256|SAAS:SAAS00593614}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:EKC99641.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AMBO01000367; EKC99641.1; -; Genomic_DNA. DR EnsemblFungi; EKC99641; EKC99641; A1Q2_06060. DR OrthoDB; EOG092C016J; -. DR UniPathway; UPA00143; -. DR Proteomes; UP000006757; Unassembled WGS sequence. DR GO; GO:0005934; C:cellular bud tip; IEA:EnsemblFungi. DR GO; GO:0010008; C:endosome membrane; IEA:EnsemblFungi. DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:EnsemblFungi. DR GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi. DR GO; GO:0005634; C:nucleus; IEA:EnsemblFungi. DR GO; GO:0000151; C:ubiquitin ligase complex; IEA:EnsemblFungi. DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW. DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:EnsemblFungi. DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:EnsemblFungi. DR GO; GO:0034644; P:cellular response to UV; IEA:EnsemblFungi. DR GO; GO:0006333; P:chromatin assembly or disassembly; IEA:EnsemblFungi. DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IEA:EnsemblFungi. DR GO; GO:0007005; P:mitochondrion organization; IEA:EnsemblFungi. DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:EnsemblFungi. DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:EnsemblFungi. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:EnsemblFungi. DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi. DR GO; GO:0051865; P:protein autoubiquitination; IEA:EnsemblFungi. DR GO; GO:0006513; P:protein monoubiquitination; IEA:EnsemblFungi. DR GO; GO:0000209; P:protein polyubiquitination; IEA:EnsemblFungi. DR GO; GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi. DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:EnsemblFungi. DR GO; GO:0010794; P:regulation of dolichol biosynthetic process; IEA:EnsemblFungi. DR GO; GO:0032443; P:regulation of ergosterol biosynthetic process; IEA:EnsemblFungi. DR GO; GO:0031384; P:regulation of initiation of mating projection growth; IEA:EnsemblFungi. DR GO; GO:0010793; P:regulation of mRNA export from nucleus; IEA:EnsemblFungi. DR GO; GO:0010796; P:regulation of multivesicular body size; IEA:EnsemblFungi. DR GO; GO:0006808; P:regulation of nitrogen utilization; IEA:EnsemblFungi. DR GO; GO:0019220; P:regulation of phosphate metabolic process; IEA:EnsemblFungi. DR GO; GO:0032880; P:regulation of protein localization; IEA:EnsemblFungi. DR GO; GO:2000203; P:regulation of ribosomal large subunit export from nucleus; IEA:EnsemblFungi. DR GO; GO:2000232; P:regulation of rRNA processing; IEA:EnsemblFungi. DR GO; GO:2000238; P:regulation of tRNA export from nucleus; IEA:EnsemblFungi. DR GO; GO:2000235; P:regulation of tRNA processing; IEA:EnsemblFungi. DR GO; GO:0010795; P:regulation of ubiquinone biosynthetic process; IEA:EnsemblFungi. DR GO; GO:0042493; P:response to drug; IEA:EnsemblFungi. DR GO; GO:0034517; P:ribophagy; IEA:EnsemblFungi. DR GO; GO:0070086; P:ubiquitin-dependent endocytosis; IEA:EnsemblFungi. DR GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi. DR Gene3D; 2.60.40.150; -; 1. DR InterPro; IPR000008; C2_dom. DR InterPro; IPR024928; E3_ub_ligase_SMURF1. DR InterPro; IPR000569; HECT_dom. DR InterPro; IPR001202; WW_dom. DR Pfam; PF00168; C2; 1. DR Pfam; PF00632; HECT; 1. DR Pfam; PF00397; WW; 3. DR PIRSF; PIRSF001569; E3_ub_ligase_SMURF1; 1. DR SMART; SM00119; HECTc; 1. DR SMART; SM00456; WW; 3. DR SUPFAM; SSF49562; SSF49562; 1. DR SUPFAM; SSF51045; SSF51045; 3. DR SUPFAM; SSF56204; SSF56204; 1. DR PROSITE; PS50004; C2; 1. DR PROSITE; PS50237; HECT; 1. DR PROSITE; PS01159; WW_DOMAIN_1; 3. DR PROSITE; PS50020; WW_DOMAIN_2; 3. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006757}; KW Ligase {ECO:0000256|PIRNR:PIRNR001569, ECO:0000256|SAAS:SAAS00593615, KW ECO:0000313|EMBL:EKC99641.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000006757}; KW Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR001569, KW ECO:0000256|SAAS:SAAS00593691}. FT DOMAIN 1 45 C2. {ECO:0000259|PROSITE:PS50004}. FT DOMAIN 214 247 WW. {ECO:0000259|PROSITE:PS50020}. FT DOMAIN 308 341 WW. {ECO:0000259|PROSITE:PS50020}. FT DOMAIN 366 399 WW. {ECO:0000259|PROSITE:PS50020}. FT DOMAIN 455 788 HECT (E6AP-type E3 ubiquitin-protein FT ligase). {ECO:0000259|PROSITE:PS50237}. FT ACT_SITE 756 756 Glycyl thioester intermediate. FT {ECO:0000256|PIRSR:PIRSR001569-1}. SQ SEQUENCE 788 AA; 88701 MW; 4F249DDBE0A0CDBE CRC64; MKRTLNPYWN ENFDITVKDS SVVVVQIFDQ RKFKRRDQGF LGVINIKVSD VLDLELGGQE MLTKDLKKGS DNTPVNGKLI VYLSTQTSTP ITNPGPTPSA RPAAINTGGE SSTNSLNANN TSTPEPDSPA THNPRDSFAT GGSTTSNPTT ATTTTPSTTA INTNSTATMN SQQPSQTSPV APSQNHQQSA ISAVAGGAGS AGNTQFDSHS DQLGPLPHGW ERRIDHLGRQ YYVDHNTRTT TWSRPSSDQQ SNTNNAANST GVARAHHNTR LTAEDMLGAN TTGGSQTPNQ GQPTTIGSTN QATTVGSGPL PAGWEQRFTP EGRPYFVDHN TRTTTWVDPR RQQLLRVMAP NQPGVTVQQQ SVTTLGPLPS GWEMRLTSTA RVYFVDHNTK TTTWDDPRLP SSLDQNVPQY KRDFRRKLIY FRSQPALRSN TGQCHVKVSR NNIFEGSYTE IMRQTPNDLK KRLMIKFEGE DGLDYGGLSR EFFFLLSHEM FNPFYCLFEY SAHDNYTLQI NPNSGVNPEH LNYFKFIGRV VGLGIFHRRF LDAYFIVAFY KMILKKRISL ADLESVDASL HRSLTWMLEN DITDIIEETF SITEEHFGEM VTVDLKENGQ NIEVNEDNKK EYVDLVTEYR ISRRVSQQFE SFMSGFNEII PQELINVFDE RELELLIGGM SEIDVDDWQK HTDYRGYNPS DEVIEWFWKI VRSWPAERKS RLLQFTTGTS RIPVNGFKDL QGSDGPRRFT IEKAGEITQL PKSHTCFNRI DLPAYKTYES LEQKLTIAVD ETEGFGQE //