ID K0JR33_SACES Unreviewed; 261 AA. AC K0JR33; DT 28-NOV-2012, integrated into UniProtKB/TrEMBL. DT 28-NOV-2012, sequence version 1. DT 16-OCT-2013, entry version 8. DE RecName: Full=Type III pantothenate kinase; DE EC=2.7.1.33; DE AltName: Full=PanK-III; DE AltName: Full=Pantothenic acid kinase; GN Name=coaX; OrderedLocusNames=BN6_03660; OS Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / OS NBRC 15066 / NRRL 15764). OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Pseudonocardineae; Pseudonocardiaceae; Saccharothrix. OX NCBI_TaxID=1179773; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764; RX PubMed=22958348; DOI=10.1186/1471-2164-13-465; RA Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J., RA Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.; RT "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and RT comparison to the other completely sequenced Pseudonocardiaceae."; RL BMC Genomics 13:465-465(2012). CC -!- FUNCTION: Catalyzes the phosphorylation of pantothenate (Pan), the CC first step in CoA biosynthesis (By similarity). CC -!- CATALYTIC ACTIVITY: ATP + (R)-pantothenate = ADP + (R)-4'- CC phosphopantothenate. CC -!- COFACTOR: Monovalent cations (By similarity). CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from CC (R)-pantothenate: step 1/5. CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the type III pantothenate kinase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HE804045; CCH27697.1; -; Genomic_DNA. DR RefSeq; YP_007034570.1; NC_019673.1. DR EnsemblBacteria; CCH27697; CCH27697; BN6_03660. DR GeneID; 14348681; -. DR KEGG; sesp:BN6_03660; -. DR KO; K03525; -. DR UniPathway; UPA00241; UER00352. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004594; F:pantothenate kinase activity; IEA:UniProtKB-HAMAP. DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-HAMAP. DR HAMAP; MF_01274; Pantothen_kinase_3; 1; -. DR InterPro; IPR004619; Type_III_PanK. DR Pfam; PF03309; Pan_kinase; 1. DR TIGRFAMs; TIGR00671; baf; 1. PE 3: Inferred from homology; KW ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm; KW Kinase; Metal-binding; Nucleotide-binding; Transferase. FT NP_BIND 6 13 ATP (By similarity). FT REGION 109 112 Substrate binding (By similarity). FT ACT_SITE 111 111 Proton acceptor (By similarity). FT METAL 131 131 Monovalent cation (By similarity). FT BINDING 134 134 ATP (By similarity). FT BINDING 186 186 Substrate (By similarity). SQ SEQUENCE 261 AA; 27793 MW; A31EB370C92CEE4E CRC64; MLLAIDVGNT NIVLGLYDGT GDKAALVRDW RMRTDARMTA DELALTMRGL LGEYADKITG ISALSTVPAV LRELRVMLGR YYSAVPKVLV EPGVRTGVPL LVDNPKEVGS DRVINTLAAH HLHSTACVVV DFGTSTNLDV ISAKGEFLGG ALAPGIEISV DALAARAAQL RKVELVRPRS VIGKNTVECL QSGIVYGFVG QVDGLVRRIV DELQVSEPGP VTVIATGGLA PLVVTESATI HAHVPDLTLL GLRLVFERNM R //