ID K0JR33_SACES Unreviewed; 261 AA. AC K0JR33; DT 28-NOV-2012, integrated into UniProtKB/TrEMBL. DT 28-NOV-2012, sequence version 1. DT 03-SEP-2014, entry version 11. DE RecName: Full=Type III pantothenate kinase; DE EC=2.7.1.33; DE AltName: Full=PanK-III; DE AltName: Full=Pantothenic acid kinase; GN Name=coaX; OrderedLocusNames=BN6_03660; OS Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / OS NBRC 15066 / NRRL 15764). OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Pseudonocardineae; Pseudonocardiaceae; Saccharothrix. OX NCBI_TaxID=1179773; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764; RX PubMed=22958348; DOI=10.1186/1471-2164-13-465; RA Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J., RA Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.; RT "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and RT comparison to the other completely sequenced Pseudonocardiaceae."; RL BMC Genomics 13:465-465(2012). CC -!- FUNCTION: Catalyzes the phosphorylation of pantothenate (Pan), the CC first step in CoA biosynthesis (By similarity). CC -!- CATALYTIC ACTIVITY: ATP + (R)-pantothenate = ADP + (R)-4'- CC phosphopantothenate. CC -!- COFACTOR: Monovalent cations (By similarity). CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from CC (R)-pantothenate: step 1/5. CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the type III pantothenate kinase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HE804045; CCH27697.1; -; Genomic_DNA. DR RefSeq; WP_015097811.1; NC_019673.1. DR RefSeq; YP_007034570.1; NC_019673.1. DR EnsemblBacteria; CCH27697; CCH27697; BN6_03660. DR GeneID; 14348681; -. DR KEGG; sesp:BN6_03660; -. DR KO; K03525; -. DR UniPathway; UPA00241; UER00352. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004594; F:pantothenate kinase activity; IEA:UniProtKB-HAMAP. DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-HAMAP. DR HAMAP; MF_01274; Pantothen_kinase_3; 1. DR InterPro; IPR004619; Type_III_PanK. DR Pfam; PF03309; Pan_kinase; 1. DR TIGRFAMs; TIGR00671; baf; 1. PE 3: Inferred from homology; KW ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm; KW Kinase; Metal-binding; Nucleotide-binding; Transferase. FT NP_BIND 6 13 ATP (By similarity){EA15}. FT REGION 109 112 Substrate binding (By similarity). FT ACT_SITE 111 111 Proton acceptor (By similarity){EA15}. FT METAL 131 131 Monovalent cation (By similarity){EA15}. FT BINDING 134 134 ATP (By similarity){EA15}. FT BINDING 186 186 Substrate (By similarity){EA15}. SQ SEQUENCE 261 AA; 27793 MW; A31EB370C92CEE4E CRC64; MLLAIDVGNT NIVLGLYDGT GDKAALVRDW RMRTDARMTA DELALTMRGL LGEYADKITG ISALSTVPAV LRELRVMLGR YYSAVPKVLV EPGVRTGVPL LVDNPKEVGS DRVINTLAAH HLHSTACVVV DFGTSTNLDV ISAKGEFLGG ALAPGIEISV DALAARAAQL RKVELVRPRS VIGKNTVECL QSGIVYGFVG QVDGLVRRIV DELQVSEPGP VTVIATGGLA PLVVTESATI HAHVPDLTLL GLRLVFERNM R //