ID J9XVC2_SIV Unreviewed; 887 AA. AC J9XVC2; DT 28-NOV-2012, integrated into UniProtKB/TrEMBL. DT 28-NOV-2012, sequence version 1. DT 20-JUN-2018, entry version 38. DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|RuleBase:RU363095}; DE Contains: DE RecName: Full=Surface protein gp120 {ECO:0000256|RuleBase:RU363095}; DE Short=SU {ECO:0000256|RuleBase:RU363095}; DE AltName: Full=Glycoprotein 120 {ECO:0000256|RuleBase:RU363095}; DE Short=gp120 {ECO:0000256|RuleBase:RU363095}; DE Contains: DE RecName: Full=Transmembrane protein gp41 {ECO:0000256|RuleBase:RU363095}; DE Short=TM {ECO:0000256|RuleBase:RU363095}; OS Simian immunodeficiency virus - sm. OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11712 {ECO:0000313|EMBL:AFS33706.1}; RN [1] {ECO:0000313|EMBL:AFS33706.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=783 {ECO:0000313|EMBL:AFS33706.1}; RX PubMed=23035225; DOI=10.1128/JVI.02174-12; RA Dang Q., Whitted S., Goeken R.M., Brenchley J.M., Matsuda K., RA Brown C.R., Lafont B.A., Starost M.F., Iyengar R., Plishka R.J., RA Buckler-White A., Hirsch V.M.; RT "Development of neurological disease is associated with increased RT immune activation in simian immunodeficiency virus-infected RT macaques."; RL J. Virol. 86:13795-13799(2012). CC -!- SUBUNIT: The mature envelope protein (Env) consists of a CC homotrimer of non-covalently associated gp120-gp41 heterodimers. CC The resulting complex protrudes from the virus surface as a spike. CC {ECO:0000256|RuleBase:RU363095}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS00937286}; Peripheral membrane protein CC {ECO:0000256|SAAS:SAAS00937286}. Host cell membrane CC {ECO:0000256|SAAS:SAAS00936930}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00936930}. Host endosome membrane CC {ECO:0000256|SAAS:SAAS00937040}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00937040}. Virion membrane CC {ECO:0000256|SAAS:SAAS00796993}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00796993}. CC -!- DOMAIN: The 17 amino acids long immunosuppressive region is CC present in many retroviral envelope proteins. Synthetic peptides CC derived from this relatively conserved sequence inhibit immune CC function in vitro and in vivo. {ECO:0000256|RuleBase:RU363095}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ686972; AFS33706.1; -; Genomic_RNA. DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule. DR CDD; cd09909; HIV-1-like_HR1-HR2; 1. DR Gene3D; 2.170.40.20; -; 2. DR InterPro; IPR036377; Gp120_core_sf. DR InterPro; IPR000328; GP41-like. DR InterPro; IPR000777; HIV1_Gp120. DR Pfam; PF00516; GP120; 1. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; SSF56502; 3. PE 4: Predicted; KW Apoptosis {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00936854}; KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU363095}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00487956}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|RuleBase:RU363095, ECO:0000256|SAAS:SAAS00487637}; KW Host cell membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00936840}; KW Host endosome {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00936869}; KW Host membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00937255}; KW Host-virus interaction {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797036}; KW Membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797370}; KW Transmembrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797262}; KW Transmembrane helix {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797734}; KW Viral attachment to host cell {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797747}; KW Viral envelope protein {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797156, ECO:0000313|EMBL:AFS33706.1}; KW Viral penetration into host cytoplasm {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00132213}; KW Virion {ECO:0000256|RuleBase:RU363095, ECO:0000256|SAAS:SAAS00796948}; KW Virus entry into host cell {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797206}. FT TRANSMEM 698 719 Helical. {ECO:0000256|RuleBase:RU363095}. FT DOMAIN 24 532 GP120. {ECO:0000259|Pfam:PF00516}. FT DOMAIN 551 744 GP41. {ECO:0000259|Pfam:PF00517}. FT COILED 645 672 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 887 AA; 102186 MW; 1B26ACDC118B61CF CRC64; MGCLGNQLLI ALLLVSVLEI WCVQYVTVFY GVPAWKNATI PLFCATRNRD TWGTTQCLPD NDDYSELAVN ITEAFDAWDN TVTEQAIEDV WNLFETSIKP CVKLTPLCIA MRCNKTETDR WGLTGEAGTA TTTKSTTSPT TTTVTPKVIN EGDSCIKNDS CAGLEQEPMI GCKFNMTGLK RDKKTEYNET WYARDLICEQ SANESESKCY MQHCNTSVIQ ESCDKHYWDA IRFRYCAPPG YALLRCNDSN YSGFAPNCSK VVVSSCTRMM ETQTSTWFGF NGTRAENRTY IYWHGNSNRT IISLNKFYNL TMKCRRPGNK TVLPVTIMSG LVFHSQPINE RPKQAWCRFG GNWSEAIQEV KETLVKHPRY TGTNETRKIN LTAPAGGDPE VTFMWTNCRG EFLYCKMNWF LNWVEDRDQN GSRWKQQKNS EQQKRNYVPC HIRQIINTWH KVGKNVYLPP REGDLTCNST VTSLIAEIDW INNNETNITM SAEVAQLYRL ELGDYKLVEI TPIGLAPTNV RRYTTTGASR NKXGVFVLGF LGFLATAGSA MGAASLTLSA QSRTLLAGIV QQQQQLLDVV KRQQELLRLT VWGTKNLQTR VTAIEKYLKD QAQLNSWGCA FRQVCHTTVQ WPNNSLVPNW NNMTWQEWER QVDFLEANIT QLLEEAQIQQ EKNMYELQKL NSWDIFGNWF DLTSWLRYIQ YGVLIVLGVV GLRIVIYVVQ MLARLRQGYR PVFSPPPVYV QQIPIHKDQE PPTKEGEEGE GGDRGGSKSW PWQIEYIHFL IRQLIRLLTW LFSSCRDWLL RIYQTLQPVL QRLSRTLQRV REVIRIERAY LQYGWSYFQE AAQAWWRFAR ETLASAWRDI WETLGRVGRG ILAIPRRVRQ GLELTLL //