ID J9XVC2_SIV Unreviewed; 887 AA. AC J9XVC2; DT 28-NOV-2012, integrated into UniProtKB/TrEMBL. DT 28-NOV-2012, sequence version 1. DT 14-OCT-2015, entry version 18. DE RecName: Full=Endogenous retrovirus group K member 21 Env polyprotein {ECO:0000256|SAAS:SAAS00159138}; DE AltName: Full=Endogenous retrovirus group K member 113 Env polyprotein {ECO:0000256|SAAS:SAAS00159454}; DE AltName: Full=Endogenous retrovirus group K member 13-1 Env polyprotein {ECO:0000256|SAAS:SAAS00159120}; DE AltName: Full=Endogenous retrovirus group K member 18 Env polyprotein {ECO:0000256|SAAS:SAAS00159191}; DE AltName: Full=Endogenous retrovirus group K member 19 Env polyprotein {ECO:0000256|SAAS:SAAS00159354}; DE AltName: Full=Endogenous retrovirus group K member 24 Env polyprotein {ECO:0000256|SAAS:SAAS00159416}; DE AltName: Full=Endogenous retrovirus group K member 25 Env polyprotein {ECO:0000256|SAAS:SAAS00159197}; DE AltName: Full=Endogenous retrovirus group K member 6 Env polyprotein {ECO:0000256|SAAS:SAAS00158998}; DE AltName: Full=Endogenous retrovirus group K member 7 Env polyprotein {ECO:0000256|SAAS:SAAS00159103}; DE AltName: Full=Endogenous retrovirus group K member 8 Env polyprotein {ECO:0000256|SAAS:SAAS00159133}; DE AltName: Full=Endogenous retrovirus group K member 9 Env polyprotein {ECO:0000256|SAAS:SAAS00159347}; DE AltName: Full=Envelope glycoprotein gp160 {ECO:0000256|SAAS:SAAS00139992}; OS Simian immunodeficiency virus - sm. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11712 {ECO:0000313|EMBL:AFS33706.1}; RN [1] {ECO:0000313|EMBL:AFS33706.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=783 {ECO:0000313|EMBL:AFS33706.1}; RX PubMed=23035225; DOI=10.1128/JVI.02174-12; RA Dang Q., Whitted S., Goeken R.M., Brenchley J.M., Matsuda K., RA Brown C.R., Lafont B.A., Starost M.F., Iyengar R., Plishka R.J., RA Buckler-White A., Hirsch V.M.; RT "Development of neurological disease is associated with increased RT immune activation in simian immunodeficiency virus-infected RT macaques."; RL J. Virol. 86:13795-13799(2012). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ686972; AFS33706.1; -; Genomic_RNA. DR GO; GO:0044174; C:host cell endosome; IEA:UniProtKB-KW. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR Gene3D; 2.170.40.20; -; 2. DR InterPro; IPR000777; HIV1_GP160. DR InterPro; IPR000328; Retroviral_envelope_protein. DR Pfam; PF00516; GP120; 1. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; SSF56502; 3. PE 4: Predicted; KW Apoptosis {ECO:0000256|SAAS:SAAS00140089}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00132312}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|SAAS:SAAS00132404}; KW Host cell membrane {ECO:0000256|SAAS:SAAS00139780}; KW Host endosome {ECO:0000256|SAAS:SAAS00139996}; KW Host membrane {ECO:0000256|SAAS:SAAS00140080}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00139787}; KW Membrane {ECO:0000256|SAAS:SAAS00140028, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|SAAS:SAAS00140092, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00140305, KW ECO:0000256|SAM:Phobius}; KW Viral attachment to host cell {ECO:0000256|SAAS:SAAS00140366}; KW Viral envelope protein {ECO:0000256|SAAS:SAAS00140357, KW ECO:0000313|EMBL:AFS33706.1}; KW Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00132213}; KW Virion {ECO:0000256|SAAS:SAAS00139810}; KW Virus entry into host cell {ECO:0000256|SAAS:SAAS00140077}. FT TRANSMEM 698 719 Helical. {ECO:0000256|SAM:Phobius}. FT COILED 645 672 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 887 AA; 102186 MW; 1B26ACDC118B61CF CRC64; MGCLGNQLLI ALLLVSVLEI WCVQYVTVFY GVPAWKNATI PLFCATRNRD TWGTTQCLPD NDDYSELAVN ITEAFDAWDN TVTEQAIEDV WNLFETSIKP CVKLTPLCIA MRCNKTETDR WGLTGEAGTA TTTKSTTSPT TTTVTPKVIN EGDSCIKNDS CAGLEQEPMI GCKFNMTGLK RDKKTEYNET WYARDLICEQ SANESESKCY MQHCNTSVIQ ESCDKHYWDA IRFRYCAPPG YALLRCNDSN YSGFAPNCSK VVVSSCTRMM ETQTSTWFGF NGTRAENRTY IYWHGNSNRT IISLNKFYNL TMKCRRPGNK TVLPVTIMSG LVFHSQPINE RPKQAWCRFG GNWSEAIQEV KETLVKHPRY TGTNETRKIN LTAPAGGDPE VTFMWTNCRG EFLYCKMNWF LNWVEDRDQN GSRWKQQKNS EQQKRNYVPC HIRQIINTWH KVGKNVYLPP REGDLTCNST VTSLIAEIDW INNNETNITM SAEVAQLYRL ELGDYKLVEI TPIGLAPTNV RRYTTTGASR NKXGVFVLGF LGFLATAGSA MGAASLTLSA QSRTLLAGIV QQQQQLLDVV KRQQELLRLT VWGTKNLQTR VTAIEKYLKD QAQLNSWGCA FRQVCHTTVQ WPNNSLVPNW NNMTWQEWER QVDFLEANIT QLLEEAQIQQ EKNMYELQKL NSWDIFGNWF DLTSWLRYIQ YGVLIVLGVV GLRIVIYVVQ MLARLRQGYR PVFSPPPVYV QQIPIHKDQE PPTKEGEEGE GGDRGGSKSW PWQIEYIHFL IRQLIRLLTW LFSSCRDWLL RIYQTLQPVL QRLSRTLQRV REVIRIERAY LQYGWSYFQE AAQAWWRFAR ETLASAWRDI WETLGRVGRG ILAIPRRVRQ GLELTLL //