ID J9KB04_ACYPI Unreviewed; 485 AA. AC J9KB04; DT 31-OCT-2012, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 1. DT 18-SEP-2019, entry version 43. DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007}; DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007}; GN Name=100169524 {ECO:0000313|EnsemblMetazoa:ACYPI010135-PA}; OS Acyrthosiphon pisum (Pea aphid). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; OC Aphidomorpha; Aphidoidea; Aphididae; Macrosiphini; Acyrthosiphon. OX NCBI_TaxID=7029 {ECO:0000313|EnsemblMetazoa:ACYPI010135-PA, ECO:0000313|Proteomes:UP000007819}; RN [1] {ECO:0000313|EnsemblMetazoa:ACYPI010135-PA} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LSR1 {ECO:0000313|EnsemblMetazoa:ACYPI010135-PA}; RA Jiang H., Abraham K., Ali S., Alsbrooks S.L., Anim B.N., Anosike U.S., RA Attaway T., Bandaranaike D.P., Battles P.K., Bell S.N., Bell A.V., RA Beltran B., Bickham C., Bustamante Y., Caleb T., Canada A., RA Cardenas V., Carter K., Chacko J., Chandrabose M.N., Chavez D., RA Chavez A., Chen L., Chu H.-S., Claassen K.J., Cockrell R., Collins M., RA Cooper J.A., Cree A., Curry S.M., Da Y., Dao M.D., Das B., RA Davila M.-L., Davy-Carroll L., Denson S., Dinh H., Ebong V.E., RA Edwards J.R., Egan A., El-Daye J., Escobedo L., Fernandez S., RA Fernando P.R., Flagg N., Forbes L.D., Fowler R.G., Fu Q., Gabisi R.A., RA Ganer J., Garbino Pronczuk A., Garcia R.M., Garner T., Garrett T.E., RA Gonzalez D.A., Hamid H., Hawkins E.S., Hirani K., Hogues M.E., RA Hollins B., Hsiao C.-H., Jabil R., James M.L., Jhangiani S.N., RA Johnson B., Johnson Q., Joshi V., Kalu J.B., Kam C., Kashfia A., RA Keebler J., Kisamo H., Kovar C.L., Lago L.A., Lai C.-Y., Laidlaw J., RA Lara F., Le T.-K., Lee S.L., Legall F.H., Lemon S.J., Lewis L.R., RA Li B., Liu Y., Liu Y.-S., Lopez J., Lozado R.J., Lu J., Madu R.C., RA Maheshwari M., Maheshwari R., Malloy K., Martinez E., Mathew T., RA Mercado I.C., Mercado C., Meyer B., Montgomery K., Morgan M.B., RA Munidasa M., Nazareth L.V., Nelson J., Ng B.M., Nguyen N.B., RA Nguyen P.Q., Nguyen T., Obregon M., Okwuonu G.O., Onwere C.G., RA Orozco G., Parra A., Patel S., Patil S., Perez A., Perez Y., Pham C., RA Primus E.L., Pu L.-L., Puazo M., Qin X., Quiroz J.B., Reese J., RA Richards S., Rives C.M., Robberts R., Ruiz S.J., Ruiz M.J., RA Santibanez J., Schneider B.W., Sisson I., Smith M., Sodergren E., RA Song X.-Z., Song B.B., Summersgill H., Thelus R., Thornton R.D., RA Trejos Z.Y., Usmani K., Vattathil S., Villasana D., Walker D.L., RA Wang S., Wang K., White C.S., Williams A.C., Williamson J., Wilson K., RA Woghiren I.O., Woodworth J.R., Worley K.C., Wright R.A., Wu W., RA Young L., Zhang L., Zhang J., Zhu Y., Muzny D.M., Weinstock G., RA Gibbs R.A.; RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EnsemblMetazoa:ACYPI010135-PA} RP IDENTIFICATION. RG EnsemblMetazoa; RL Submitted (JUN-2015) to UniProtKB. CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- CC phosphate and glycerone phosphate from D-glucose: step 1/4. CC {ECO:0000256|SAAS:SAAS01216704}. CC -!- SIMILARITY: Belongs to the hexokinase family. CC {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672880}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ABLF02024587; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_001949411.1; XM_001949376.4. DR STRING; 7029.ACYPI010135-PA; -. DR EnsemblMetazoa; ACYPI010135-RA; ACYPI010135-PA; ACYPI010135. DR GeneID; 100169524; -. DR KEGG; api:100169524; -. DR eggNOG; KOG1369; Eukaryota. DR eggNOG; COG5026; LUCA. DR InParanoid; J9KB04; -. DR KO; K00844; -. DR OMA; ISGKYMG; -. DR OrthoDB; 1153545at2759; -. DR PhylomeDB; J9KB04; -. DR UniPathway; UPA00109; UER00180. DR Proteomes; UP000007819; Unassembled WGS sequence. DR GO; GO:0005623; C:cell; IEA:GOC. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0005536; F:glucose binding; IEA:InterPro. DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro. DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW. DR InterPro; IPR001312; Hexokinase. DR InterPro; IPR019807; Hexokinase_BS. DR InterPro; IPR022673; Hexokinase_C. DR InterPro; IPR022672; Hexokinase_N. DR PANTHER; PTHR19443; PTHR19443; 1. DR Pfam; PF00349; Hexokinase_1; 1. DR Pfam; PF03727; Hexokinase_2; 1. DR PROSITE; PS00378; HEXOKINASE_1; 1. DR PROSITE; PS51748; HEXOKINASE_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|RuleBase:RU362007, KW ECO:0000256|SAAS:SAAS00216502}; KW Complete proteome {ECO:0000313|Proteomes:UP000007819}; KW Glycolysis {ECO:0000256|RuleBase:RU362007, KW ECO:0000256|SAAS:SAAS00216492}; KW Kinase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00216507}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU362007, KW ECO:0000256|SAAS:SAAS00672883}; KW Reference proteome {ECO:0000313|Proteomes:UP000007819}; KW Transferase {ECO:0000256|RuleBase:RU362007, KW ECO:0000256|SAAS:SAAS00672884}. FT DOMAIN 35 231 Hexokinase_1. {ECO:0000259|Pfam:PF00349}. FT DOMAIN 237 469 Hexokinase_2. {ECO:0000259|Pfam:PF03727}. SQ SEQUENCE 485 AA; 53854 MW; 0026A9A6C4B08364 CRC64; MRTKPEMMGQ LRPAFSELNI SEGFEFDTEL VTNEIKEDCK SLLLSNEQLT TLMKDMDGAI RNGLGKDTNP SSIVKCYVTY VQDLPNGTER GKFLALDLGG TNFRVLLIEL GENNYFHMDS EIFKVPAHIQ TGKGSELFDH IAKCLAEFIK KHNLDNKKAL PLGFTFSFPL RQVGLTKGYL NSWTKGFNCS GVVDEDVVRL LKEAIKRRKD VEIDVCGILN DTTGTIMSCA WKNPNTKIGV IVGTGCNACY VEKVENAELF DGDKTKPHVI VNTEWGAFGD DGKLDAVRTK YDREIDEDSL NPGRQRFEKM ISGMYMGEIV RLAIVDLANQ NKLFEGRLSE QMKTKGAFGT SFVSDIEGDK ANYKETLKVL SEMGINDPSL VDCANVRYIC ECVSRRSAHL VSAGLAALLN KMDEKSVTIG VDGSVYRFHP YFHKLMVEKT KQLTKSDIKF DLMLSEDGSG RGAALVAAVA VRDELPSMTN GFSAK //