ID J3QT58_HUMAN Unreviewed; 182 AA. AC J3QT58; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 03-MAY-2023, entry version 69. DE SubName: Full=Carboxypeptidase A2 {ECO:0000313|Ensembl:ENSP00000395582.1}; DE SubName: Full=Carboxypeptidase A2 isoform 2 {ECO:0000313|EMBL:ALQ33449.1}; GN Name=CPA2 {ECO:0000313|EMBL:ALQ33449.1, GN ECO:0000313|Ensembl:ENSP00000395582.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000395582.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000395582.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., RA Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000313|EMBL:ALQ33449.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26871637; DOI=10.1016/j.cell.2016.01.029; RA Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T., RA Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K., RA Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q., RA Trigg S.A., Tam S., Ghamsari L., Sahni N., Yi S., Rodriguez M.D., RA Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J., RA Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P., RA Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.; RT "Widespread Expansion of Protein Interaction Capabilities by Alternative RT Splicing."; RL Cell 164:805-817(2016). RN [3] {ECO:0000313|Ensembl:ENSP00000395582.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2023) to UniProtKB. CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|ARBA:ARBA00001947}; CC -!- SIMILARITY: Belongs to the peptidase M14 family. CC {ECO:0000256|ARBA:ARBA00005988}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC024085; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KU177991; ALQ33449.1; -; mRNA. DR Ensembl; ENST00000416698.1; ENSP00000395582.1; ENSG00000158516.12. DR UCSC; uc064hyv.1; human. DR HGNC; HGNC:2297; CPA2. DR VEuPathDB; HostDB:ENSG00000158516; -. DR GeneTree; ENSGT00940000160121; -. DR HOGENOM; CLU_019326_5_0_1; -. DR ChiTaRS; CPA2; human. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000158516; Expressed in body of pancreas and 100 other tissues. DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:InterPro. DR Gene3D; 3.30.70.340; Metallocarboxypeptidase-like; 1. DR Gene3D; 3.40.630.10; Zn peptidases; 1. DR InterPro; IPR036990; M14A-like_propep. DR InterPro; IPR003146; M14A_act_pep. DR InterPro; IPR000834; Peptidase_M14. DR PANTHER; PTHR11705:SF71; CARBOXYPEPTIDASE A2; 1. DR PANTHER; PTHR11705; PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B; 1. DR Pfam; PF00246; Peptidase_M14; 1. DR Pfam; PF02244; Propep_M14; 1. DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1. DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1. PE 1: Evidence at protein level; KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645, KW ECO:0000313|EMBL:ALQ33449.1}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Hydrolase {ECO:0000256|ARBA:ARBA00023049}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049}; KW Protease {ECO:0000256|ARBA:ARBA00023049}; KW Proteomics identification {ECO:0007829|MaxQB:J3QT58, KW ECO:0007829|PeptideAtlas:J3QT58}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. FT SIGNAL 1..16 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 17..182 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5014579734" FT DOMAIN 27..100 FT /note="Carboxypeptidase activation peptide" FT /evidence="ECO:0000259|Pfam:PF02244" FT DOMAIN 128..166 FT /note="Peptidase M14 carboxypeptidase A" FT /evidence="ECO:0000259|Pfam:PF00246" FT REGION 159..182 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 182 AA; 20832 MW; 6F707DB75CF57A7E CRC64; MRLILFFGAL FGHIYCLETF VGDQVLEIVP SNEEQIKNLL QLEAQEHLQL DFWKSPTTPG ETAHVRVPFV NVQAVKVFLE SQGIAYSIMI EDVQVLLDKE NEEMLFNRRR ERSGNFNFGA YHTLEEISQE MDNLVAEHPG LVSKVNIGSS FENRPMNVLK KSSGRMQKDD GQLNPKPQRQ TP //