ID J3QT58_HUMAN Unreviewed; 182 AA. AC J3QT58; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 12-APR-2017, entry version 33. DE SubName: Full=Carboxypeptidase A2 {ECO:0000313|Ensembl:ENSP00000395582}; DE SubName: Full=Carboxypeptidase A2 isoform 2 {ECO:0000313|EMBL:ALQ33449.1}; GN Name=CPA2 {ECO:0000313|EMBL:ALQ33449.1, GN ECO:0000313|Ensembl:ENSP00000395582}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000395582, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., RA Waterston R.H., Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000395582} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [3] {ECO:0000313|Ensembl:ENSP00000395582} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2012) to UniProtKB. RN [4] {ECO:0000313|EMBL:ALQ33449.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26871637; DOI=10.1016/j.cell.2016.01.029; RA Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T., RA Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K., RA Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q., RA Trigg S.A., Tam S., Ghamsari L., Sahni N., Yi S., Rodriguez M.D., RA Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J., RA Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P., RA Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.; RT "Widespread Expansion of Protein Interaction Capabilities by RT Alternative Splicing."; RL Cell 164:805-817(2016). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC024085; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KU177991; ALQ33449.1; -; mRNA. DR UniGene; Hs.490038; -. DR ProteinModelPortal; J3QT58; -. DR SMR; J3QT58; -. DR STRING; 9606.ENSP00000222481; -. DR PaxDb; J3QT58; -. DR Ensembl; ENST00000416698; ENSP00000395582; ENSG00000158516. DR UCSC; uc064hyv.1; human. DR HGNC; HGNC:2297; CPA2. DR OpenTargets; ENSG00000158516; -. DR eggNOG; KOG2650; Eukaryota. DR eggNOG; COG2866; LUCA. DR GeneTree; ENSGT00760000119103; -. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000158516; -. DR ExpressionAtlas; J3QT58; baseline and differential. DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR Gene3D; 3.30.70.340; -; 1. DR InterPro; IPR003146; M14A_act_pep. DR InterPro; IPR000834; Peptidase_M14. DR InterPro; IPR009020; Propept_inh. DR Pfam; PF00246; Peptidase_M14; 1. DR Pfam; PF02244; Propep_M14; 1. DR SUPFAM; SSF54897; SSF54897; 1. PE 1: Evidence at protein level; KW Carboxypeptidase {ECO:0000313|EMBL:ALQ33449.1}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Hydrolase {ECO:0000313|EMBL:ALQ33449.1}; KW Protease {ECO:0000313|EMBL:ALQ33449.1}; KW Proteomics identification {ECO:0000213|PeptideAtlas:J3QT58}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 182 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5009701322. FT DOMAIN 27 100 Propep_M14. {ECO:0000259|Pfam:PF02244}. FT DOMAIN 128 166 Peptidase_M14. {ECO:0000259|Pfam: FT PF00246}. SQ SEQUENCE 182 AA; 20832 MW; 6F707DB75CF57A7E CRC64; MRLILFFGAL FGHIYCLETF VGDQVLEIVP SNEEQIKNLL QLEAQEHLQL DFWKSPTTPG ETAHVRVPFV NVQAVKVFLE SQGIAYSIMI EDVQVLLDKE NEEMLFNRRR ERSGNFNFGA YHTLEEISQE MDNLVAEHPG LVSKVNIGSS FENRPMNVLK KSSGRMQKDD GQLNPKPQRQ TP //