ID   J3KSH6_HUMAN            Unreviewed;       145 AA.
AC   J3KSH6;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   19-JAN-2022, entry version 62.
DE   SubName: Full=Transcription factor HES-7 {ECO:0000313|Ensembl:ENSP00000462491};
DE   Flags: Fragment;
GN   Name=HES7 {ECO:0000313|Ensembl:ENSP00000462491};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000462491, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000462491, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000462491}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
CC   -!- SUBUNIT: Transcription repression requires formation of a complex with
CC       a corepressor protein of the Groucho/TLE family.
CC       {ECO:0000256|ARBA:ARBA00023791}.
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DR   EMBL; AC129492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; J3KSH6; -.
DR   PeptideAtlas; J3KSH6; -.
DR   PRIDE; J3KSH6; -.
DR   Antibodypedia; 6182; 225 antibodies from 27 providers.
DR   Ensembl; ENST00000577735; ENSP00000462491; ENSG00000179111.
DR   UCSC; uc060aya.1; human.
DR   HGNC; HGNC:15977; HES7.
DR   OpenTargets; ENSG00000179111; -.
DR   VEuPathDB; HostDB:ENSG00000179111; -.
DR   GeneTree; ENSGT00730000111282; -.
DR   HOGENOM; CLU_068550_5_0_1; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000179111; Expressed in cerebellar hemisphere and 108 other tissues.
DR   ExpressionAtlas; J3KSH6; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR032644; HES-7.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003650; Orange_dom.
DR   PANTHER; PTHR10985:SF84; PTHR10985:SF84; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS51054; ORANGE; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|PeptideAtlas:J3KSH6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT   DOMAIN          4..61
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          89..119
FT                   /note="Orange"
FT                   /evidence="ECO:0000259|PROSITE:PS51054"
FT   REGION          122..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..145
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         145
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000462491"
SQ   SEQUENCE   145 AA;  16406 MW;  4E6F534501A603C4 CRC64;
     MRRSGEMLKP LVEKRRRDRI NRSLEELRLL LLERTRDQNL RNPKLEKAEI LEFAVGYLRE
     RSRVEPPAAA APGVPRSPVQ DAEALASCYL SGFRECLLRL AAFAHDASPA ARAQLFSALH
     GYLRPKPPRP KPVDPRPPAP RPSLD
//