ID   J3KSH6_HUMAN            Unreviewed;       145 AA.
AC   J3KSH6;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   17-JUN-2020, entry version 55.
DE   SubName: Full=Transcription factor HES-7 {ECO:0000313|Ensembl:ENSP00000462491};
DE   Flags: Fragment;
GN   Name=HES7 {ECO:0000313|Ensembl:ENSP00000462491};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000462491, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000462491, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000462491}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00812946}.
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DR   EMBL; AC129492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; J3KSH6; -.
DR   PeptideAtlas; J3KSH6; -.
DR   PRIDE; J3KSH6; -.
DR   Antibodypedia; 6182; 195 antibodies.
DR   Ensembl; ENST00000577735; ENSP00000462491; ENSG00000179111.
DR   UCSC; uc060aya.1; human.
DR   EuPathDB; HostDB:ENSG00000179111.8; -.
DR   HGNC; HGNC:15977; HES7.
DR   OpenTargets; ENSG00000179111; -.
DR   eggNOG; ENOG410KCUT; Eukaryota.
DR   eggNOG; ENOG4112CME; LUCA.
DR   GeneTree; ENSGT00730000111282; -.
DR   HOGENOM; CLU_068550_5_0_1; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000179111; Expressed in cerebellar hemisphere and 90 other tissues.
DR   ExpressionAtlas; J3KSH6; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR   CDD; cd00083; HLH; 1.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR032644; HES-7.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003650; Orange_dom.
DR   PANTHER; PTHR10985:SF84; PTHR10985:SF84; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS51054; ORANGE; 1.
PE   1: Evidence at protein level;
KW   Nucleus {ECO:0000256|SAAS:SAAS00812956};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:J3KSH6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transcription {ECO:0000256|SAAS:SAAS00812945};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00812944}.
FT   DOMAIN          4..61
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          89..119
FT                   /note="Orange"
FT                   /evidence="ECO:0000259|PROSITE:PS51054"
FT   REGION          122..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..145
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         145
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000462491"
SQ   SEQUENCE   145 AA;  16406 MW;  4E6F534501A603C4 CRC64;
     MRRSGEMLKP LVEKRRRDRI NRSLEELRLL LLERTRDQNL RNPKLEKAEI LEFAVGYLRE
     RSRVEPPAAA APGVPRSPVQ DAEALASCYL SGFRECLLRL AAFAHDASPA ARAQLFSALH
     GYLRPKPPRP KPVDPRPPAP RPSLD
//