ID J3KS13_HUMAN Unreviewed; 612 AA. AC J3KS13; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 22-APR-2020, entry version 59. DE SubName: Full=Clathrin heavy chain 1 {ECO:0000313|Ensembl:ENSP00000462252}; GN Name=CLTC {ECO:0000313|Ensembl:ENSP00000462252}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000462252, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000462252, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the RT human lineage."; RL Nature 440:1045-1049(2006). RN [2] {ECO:0000213|PubMed:19369195} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200; RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., RA Mann M., Daub H.; RT "Large-scale proteomics analysis of the human kinome."; RL Mol. Cell. Proteomics 8:1751-1764(2009). RN [3] {ECO:0000213|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [4] {ECO:0000213|PubMed:19608861} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19608861; DOI=10.1126/science.1175371; RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., RA Olsen J.V., Mann M.; RT "Lysine acetylation targets protein complexes and co-regulates major RT cellular functions."; RL Science 325:834-840(2009). RN [5] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [6] {ECO:0000213|PubMed:22223895} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22223895; DOI=10.1074/mcp.M111.015131; RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., RA Giglione C.; RT "Comparative large-scale characterisation of plant vs. mammal proteins RT reveals similar and idiosyncratic N-alpha acetylation features."; RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012). RN [7] {ECO:0000213|PubMed:22814378} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22814378; DOI=10.1073/pnas.1210303109; RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.; RT "N-terminal acetylome analyses and functional insights of the N-terminal RT acetyltransferase NatB."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). RN [8] {ECO:0000313|Ensembl:ENSP00000462252} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2012) to UniProtKB. RN [9] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [10] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [11] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC091271; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; J3KS13; -. DR MaxQB; J3KS13; -. DR PeptideAtlas; J3KS13; -. DR PRIDE; J3KS13; -. DR Antibodypedia; 4164; 478 antibodies. DR Ensembl; ENST00000579456; ENSP00000462252; ENSG00000141367. DR UCSC; uc060ida.1; human. DR EuPathDB; HostDB:ENSG00000141367.11; -. DR HGNC; HGNC:2092; CLTC. DR OpenTargets; ENSG00000141367; -. DR eggNOG; KOG0985; Eukaryota. DR eggNOG; ENOG410XPH1; LUCA. DR GeneTree; ENSGT00950000183166; -. DR HOGENOM; CLU_446148_0_0_1; -. DR ChiTaRS; CLTC; human. DR Proteomes; UP000005640; Chromosome 17. DR Bgee; ENSG00000141367; Expressed in dorsolateral prefrontal cortex and 239 other tissues. DR ExpressionAtlas; J3KS13; baseline and differential. DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro. DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro. DR GO; GO:0005768; C:endosome; IDA:HPA. DR GO; GO:0005764; C:lysosome; IDA:HPA. DR GO; GO:0072686; C:mitotic spindle; IDA:HPA. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule. DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro. DR Gene3D; 1.25.40.10; -; 1. DR Gene3D; 2.130.10.110; -; 1. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat. DR InterPro; IPR016025; Clathrin_H-chain_N. DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR Pfam; PF00637; Clathrin; 3. DR Pfam; PF01394; Clathrin_propel; 1. DR SMART; SM00299; CLH; 3. DR SUPFAM; SSF48371; SSF48371; 1. DR SUPFAM; SSF50989; SSF50989; 1. DR PROSITE; PS50236; CHCR; 3. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0000213|EPD:J3KS13, KW ECO:0000213|MaxQB:J3KS13, ECO:0000213|PeptideAtlas:J3KS13, KW ECO:0000213|ProteomicsDB:J3KS13}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT REPEAT 65..206 FT /note="CHCR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006" FT REPEAT 211..357 FT /note="CHCR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006" FT REPEAT 360..503 FT /note="CHCR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006" SQ SEQUENCE 612 AA; 70653 MW; EF3E5FDDE8E848FA CRC64; MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV VIIDMNDPSN PIRRPISADS AIMNPASKVI ALKAGKTLQI FNIEMKSKMK ARESYVETEL IFALAKTNRL AELEEFINGP NNAHIQQVGD RCYDEKMYDA AKLLYNNVSN FGRLASTLVH LGEYQAAVDG ARKANSTRTW KEVCFACVDG KEFRLAQMCG LHIVVHADEL EELINYYQDR GYFEELITML EAALGLERAH MGMFTELAIL YSKFKPQKMR EHLELFWSRV NIPKVLRAAE QAHLWAELVF LYDKYEEYDN AIITMMNHPT DAWKEGQFKD IITKVANVEL YYRAIQFYLE FKPLLLNDLL MVLSPRLDHT RAVNYFSKVK QLPLVKPYLR SVQNHNNKSV NESLNNLFIT EEDYQALRTS IDAYDNFDNI SLAQRLEKHE LIEFRRIAAY LFKGNNRWKQ SVELCKKDSL YKDAMQYASE SKDTELAEEL LQWFLQEEKR ECFGACLFTC YDLLRPDVVL ETAWRHNIMD FAMPYFIQVM KEYLTKVDKL DASESLRKEE EQATETQPIV YGQPQLMLTA GPSVAVPPQA PFGYGYTAPP YGQPQPGFGY SM //