ID J3KNX3_HUMAN Unreviewed; 851 AA. AC J3KNX3; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 31-OCT-2012, entry version 2. DE RecName: Full=6-phosphofructokinase; DE EC=2.7.1.11; DE AltName: Full=Phosphohexokinase; GN Name=PFKM; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16541075; DOI=10.1038/nature04569; RG Baylor College of Medicine Human Genome Sequencing Center Sequence RG Production Team; RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., RA Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., RA Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., RA Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., RA Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., RA Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., RA Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., RA Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., RA Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., RA Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., RA Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., RA Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., RA Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., RA Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., RA Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., RA Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., RA Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., RA Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., RA Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., RA Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., RA Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., RA Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., RA Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., RA Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., RA Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., RA Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., RA Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., RA Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., RA Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., RA Kucherlapati R., Weinstock G., Gibbs R.A., null.; RT "The finished DNA sequence of human chromosome 12."; RL Nature 440:346-351(2006). RN [2] RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2012) to UniProtKB. CC -!- CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + D- CC fructose 1,6-bisphosphate. CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- CC phosphate and glycerone phosphate from D-glucose: step 3/4. CC -!- SIMILARITY: Belongs to the phosphofructokinase family. Two domains CC subfamily. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC004801; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC074029; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001160158.1; NM_001166686.1. DR Ensembl; ENST00000340802; ENSP00000345771; ENSG00000152556. DR GeneID; 5213; -. DR HGNC; HGNC:8877; PFKM. DR UniPathway; UPA00109; UER00182. DR HAMAP; MF_00339; Phosphofructokinase; 1; -. DR InterPro; IPR009161; 6-phosphofructokinase_euk. DR InterPro; IPR022953; Phosphofructokinase. DR InterPro; IPR015912; Phosphofructokinase_CS. DR InterPro; IPR000023; Phosphofructokinase_dom. DR Pfam; PF00365; PFK; 2. DR PIRSF; PIRSF000533; ATP_PFK_euk; 1. DR PRINTS; PR00476; PHFRCTKINASE. DR SUPFAM; SSF53784; Ppfruckinase; 2. DR TIGRFAMs; TIGR02478; 6PF1K_euk; 1. DR PROSITE; PS00433; PHOSPHOFRUCTOKINASE; 2. PE 3: Inferred from homology; KW ATP-binding; Complete proteome; Glycolysis; Kinase; KW Nucleotide-binding; Reference proteome; Transferase. SQ SEQUENCE 851 AA; 93254 MW; A09ABE529E682EC4 CRC64; MHKDEFHLKF FMCVIQSRQL VRTPQRTAGE ASTSSMLIPK PPPKTDILKS LDTMDDPDTV GSIPVFKTEW IMTHEEHHAA KTLGIGKAIA VLTSGGDAQG MNAAVRAVVR VGIFTGARVF FVHEGYQGLV DGGDHIKEAT WESVSMMLQL GGTVIGSARC KDFREREGRL RAAYNLVKRG ITNLCVIGGD GSLTGADTFR SEWSDLLSDL QKAGKITDEE ATKSSYLNIV GLVGSIDNDF CGTDMTIGTD SALHRIMEIV DAITTTAQSH QRTFVLEVMG RHCGYLALVT SLSCGADWVF IPECPPDDDW EEHLCRRLSE TRTRGSRLNI IIVAEGAIDK NGKPITSEDI KNLVVKRLGY DTRVTVLGHV QRGGTPSAFD RILGSRMGVE AVMALLEGTP DTPACVVSLS GNQAVRLPLM ECVQVTKDVT KAMDEKKFDE ALKLRGRSFM NNWEVYKLLA HVRPPVSKSG SHTVAVMNVG APAAGMNAAV RSTVRIGLIQ GNRVLVVHDG FEGLAKGQIE EAGWSYVGGW TGQGGSKLGT KRTLPKKSFE QISANITKFN IQGLVIIGGF EAYTGGLELM EGRKQFDELC IPFVVIPATV SNNVPGSDFS VGADTALNTI CTTCDRIKQS AAGTKRRVFI IETMGGYCGY LATMAGLAAG ADAAYIFEEP FTIRDLQANV EHLVQKMKTT VKRGLVLRNE KCNENYTTDF IFNLYSEEGK GIFDSRKNVL GHMQQGGSPT PFDRNFATKM GAKAMNWMSG KIKESYRNGR IFANTPDSGC VLGMRKRALV FQPVAELKDQ TDFEHRIPKE QWWLKLRPIL KILAKYEIDL DTSDHAHLEH ITRKRSGEAA V //