ID J3KN39_HUMAN Unreviewed; 1059 AA. AC J3KN39; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 28-JUN-2023, entry version 89. DE SubName: Full=NACHT, LRR and PYD domains-containing protein 2 {ECO:0000313|Ensembl:ENSP00000479677.1}; DE SubName: Full=NLR family pyrin domain containing 2 {ECO:0000313|Ensembl:ENSP00000263437.6}; GN Name=NLRP2 {ECO:0000313|Ensembl:ENSP00000263437.6}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000263437.6, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000263437.6, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0007829|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0007829|PubMed:21406692} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [4] {ECO:0007829|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [5] {ECO:0000313|Ensembl:ENSP00000263437.6} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the NLRP family. CC {ECO:0000256|ARBA:ARBA00008665}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC011476; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001334932.1; NM_001348003.1. DR Antibodypedia; 19479; 335 antibodies from 39 providers. DR DNASU; 55655; -. DR Ensembl; ENST00000263437.10; ENSP00000263437.6; ENSG00000022556.16. DR Ensembl; ENST00000612740.4; ENSP00000479677.1; ENSG00000273992.4. DR GeneID; 55655; -. DR UCSC; uc010eso.4; human. DR CTD; 55655; -. DR HGNC; HGNC:22948; NLRP2. DR VEuPathDB; HostDB:ENSG00000022556; -. DR GeneTree; ENSGT00940000161714; -. DR OrthoDB; 55870at2759; -. DR BioGRID-ORCS; 55655; 21 hits in 1150 CRISPR screens. DR ChiTaRS; NLRP2; human. DR GenomeRNAi; 55655; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000022556; Expressed in placenta and 99 other tissues. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. DR CDD; cd08320; Pyrin_NALPs; 1. DR Gene3D; 1.10.533.10; Death Domain, Fas; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1. DR InterPro; IPR004020; DAPIN. DR InterPro; IPR011029; DEATH-like_dom_sf. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR007111; NACHT_NTPase. DR InterPro; IPR041267; NLRP_HD2. DR InterPro; IPR041075; NOD2_WH. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1. DR PANTHER; PTHR45690:SF14; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 2; 1. DR Pfam; PF13516; LRR_6; 4. DR Pfam; PF05729; NACHT; 1. DR Pfam; PF17776; NLRC4_HD2; 1. DR Pfam; PF17779; NOD2_WH; 1. DR Pfam; PF02758; PYRIN; 1. DR SMART; SM00368; LRR_RI; 8. DR SMART; SM01289; PYRIN; 1. DR SUPFAM; SSF47986; DEATH domain; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR SUPFAM; SSF52047; RNI-like; 1. DR PROSITE; PS50824; DAPIN; 1. DR PROSITE; PS50837; NACHT; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614}; KW Proteomics identification {ECO:0007829|EPD:J3KN39, KW ECO:0007829|MaxQB:J3KN39}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 1..94 FT /note="Pyrin" FT /evidence="ECO:0000259|PROSITE:PS50824" FT DOMAIN 204..402 FT /note="NACHT" FT /evidence="ECO:0000259|PROSITE:PS50837" FT COILED 1010..1041 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 1059 AA; 120196 MW; 55CAC1EF9719A3C2 CRC64; MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA DGKQLVEILT THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF NKRKPLSLGI TRKERPPLDV DEMLERFKTE AQETKGNVIC LGKEVFKGKK PDKDNRCRYI LKTKFREMWK SWPGDSKEVQ VMAERYKMLI PFSNPRVLPG PFSYTVVLYG PAGLGKTTLA QKLMLDWAED NLIHKFKYAF YLSCRELSRL GPCSFAELVF RDWPELQDDI PHILAQARKI LFVIDGFDEL GAAPGALIED ICGDWEKKKP VPVLLGSLLN RVMLPKAALL VTTRPRALRD LRILAEEPIY IRVEGFLEED RRAYFLRHFG DEDQAMRAFE LMRSNAALFQ LGSAPAVCWI VCTTLKLQME KGEDPVPTCL TRTGLFLRFL CSRFPQGAQL RGALRTLSLL AAQGLWAQTS VLHREDLERL GVQESDLRLF LDGDILRQDR VSKGCYSFIH LSFQQFLTAL FYTLEKEEEE DRDGHTWDIG DVQKLLSGVE RLRNPDLIQA GYYSFGLANE KRAKELEATF GCRMSPDIKQ ELLRCDISCK GGHSTVTDLQ ELLGCLYESQ EEELVKEVMA QFKEISLHLN AVDVVPSSFC VKHCRNLQKM SLQVIKENLP ENVTASESDA EVERSQDDQH MLPFWTDLCS IFGSNKDLMG LAINDSFLSA SLVRILCEQI ASDTCHLQRV VFKNISPADA HRNLCLALRG HKTVTYLTLQ GNDQDDMFPA LCEVLRHPEC NLRYLGLVSC SATTQQWADL SLALEVNQSL TCVNLSDNEL LDEGAKLLYT TLRHPKCFLQ RLSLENCHLT EANCKDLAAV LVVSRELTHL CLAKNPIGNT GVKFLCEGLR YPECKLQTLV LWNCDITSDG CCDLTKLLQE KSSLLCLDLG LNHIGVKGMK FLCEALRKPL CNLRCLWLWG CSIPPFSCED LCSALSCNQS LVTLDLGQNP LGSSGVKMLF ETLTCSSGTL RTLRLKIDDF NDELNKLLEE IEEKNPQLII DTEKHHPWAE RPSSHDFMI //