ID J0NTQ7_HELPX Unreviewed; 773 AA. AC J0NTQ7; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 09-JAN-2013, entry version 4. DE RecName: Full=DNA gyrase subunit B; DE EC=5.99.1.3; GN Name=gyrB; OS Helicobacter pylori Hp H-19. OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; OC Helicobacteraceae; Helicobacter. OX NCBI_TaxID=992066; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hp H-19; RA Blanchard T.G., Czinn S.J., McCracken C., Abolude K., Maroo A., RA Santana-Cruz I., Tallon L.J., Ficke F.W.F.; RT "Genome sequence of Helicobacter pylori Hp H-19."; RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: DNA gyrase negatively supercoils closed circular double- CC stranded DNA in an ATP-dependent manner and also catalyzes the CC interconversion of other topological isomers of double-stranded CC DNA rings, including catenanes and knotted rings (By similarity). CC -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining CC of double-stranded DNA. CC -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA CC breakage and rejoining; the B chain catalyzes ATP hydrolysis. The CC enzyme forms an A2B2 tetramer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the type II topoisomerase family. CC -!- SIMILARITY: Contains 1 Toprim domain. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AKPE01000004; EJB89767.1; -; Genomic_DNA. DR GO; GO:0005694; C:chromosome; IEA:InterPro. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:HAMAP. DR GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:HAMAP. DR GO; GO:0006265; P:DNA topological change; IEA:InterPro. DR GO; GO:0006261; P:DNA-dependent DNA replication; IEA:HAMAP. DR Gene3D; 3.30.565.10; ATP_bd_ATPase; 1. DR Gene3D; 3.30.230.10; Ribosomal_S5_D2-type_fold; 1. DR Gene3D; 3.40.50.670; Topo_IIA_B/N_ab; 2. DR HAMAP; MF_01898; GyrB; 1; -. DR InterPro; IPR003594; ATPase-like_ATP-bd. DR InterPro; IPR011557; GyrB. DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold. DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr. DR InterPro; IPR001241; Topo_IIA. DR InterPro; IPR013759; Topo_IIA_B/N_ab. DR InterPro; IPR002288; Topo_IIA_B_C. DR InterPro; IPR013506; Topo_IIA_bsu_dom2. DR InterPro; IPR013760; Topo_IIA_cen. DR InterPro; IPR018522; TopoIIA_CS. DR InterPro; IPR006171; Toprim_domain. DR Pfam; PF00204; DNA_gyraseB; 1. DR Pfam; PF00986; DNA_gyraseB_C; 1. DR Pfam; PF02518; HATPase_c; 1. DR Pfam; PF01751; Toprim; 1. DR PRINTS; PR00418; TPI2FAMILY. DR SMART; SM00387; HATPase_c; 1. DR SMART; SM00433; TOP2c; 1. DR SUPFAM; SSF55874; ATP_bd_ATPase; 1. DR SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 1. DR SUPFAM; SSF56719; Topo_IIA_cen; 1. DR TIGRFAMs; TIGR01059; gyrB; 1. DR PROSITE; PS00177; TOPOISOMERASE_II; 1. PE 3: Inferred from homology; KW ATP-binding; Cytoplasm; Isomerase; Nucleotide-binding; Topoisomerase. FT DOMAIN 417 528 Toprim (By similarity). SQ SEQUENCE 773 AA; 87503 MW; F25F88C038BE5E1C CRC64; MQNYQSHSIK VLKGLEGVRK RPGMYIGDTN IGGLHHMVYE VVDNAVDESM AGFCDTINIT LTEEGSCIVE DNGRGIPVDI HPTEKIPACT VVLTILHAGG KFDNDTYKVS GGLHGVGVSV VNALSKRLIM TIKKEGQIYR QEFEKGIPIS ELEIIGKTKS AKESGTTIEF FPDESVMEVV EFQAGILQKR FREMAYLNDG LKISFKEEKT QLQETYFYED GLKQFVKDSA KKELLTPIIA FKSMDEEMRT SIEVALAYAD DYNENTLSFV NNIKTSEGGT HEAGFKMGLS KAILQYIDNN IKTKDSRPIS EDIKEGLIAV VSLKMSEPLF EGQTKSKLGS SYARALVSKL VYDKIHQFLE ENPNEAKIIA NKALLAAKAR EASKKARELT RKKDNLSVGT LPGKLADCQS KDPLESEIFL VEGDSAGGSA KQGRDRVFQA ILPLKGKILN VEKSHLSKIL KSEEIKNMIT AFGCGIQESF DIERLRYHKI IIMTDADVDG SHIQTLLMTF FYRYLRPLIE QGHVYIAQAP LYKYKKGKTE IYLKDSVALD HFLIEHGINS VDIEGIGKND LMNLLKVVHH YRYTLLELEK RYNLLEVLRF LIETKDALSL DMKVLEKSIL EKLEGLNYQI LRSFATEESL HLHAQTPKGL VEFNLDDNLF KEVLFEEANY TYQKLMEYNL DFLENKDILA FLEEVENHAK KGANIQRYKG LGEMNPNDLW ETTMHKENRS LIKLKIEDLE KTDAIFSLCM GDEVEPRRAF IQAHAKDVKQ LDV //