ID I9R6Y0_HELPX Unreviewed; 287 AA. AC I9R6Y0; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 24-JAN-2024, entry version 27. DE RecName: Full=Endolytic murein transglycosylase {ECO:0000256|HAMAP-Rule:MF_02065}; DE EC=4.2.2.- {ECO:0000256|HAMAP-Rule:MF_02065}; DE AltName: Full=Peptidoglycan polymerization terminase {ECO:0000256|HAMAP-Rule:MF_02065}; GN Name=pabC {ECO:0000313|EMBL:EJB42311.1}; GN Synonyms=mltG {ECO:0000256|HAMAP-Rule:MF_02065}; GN ORFNames=HPHPA4_0798 {ECO:0000313|EMBL:EJB42311.1}; OS Helicobacter pylori Hp A-4. OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales; OC Helicobacteraceae; Helicobacter. OX NCBI_TaxID=992032 {ECO:0000313|EMBL:EJB42311.1, ECO:0000313|Proteomes:UP000003633}; RN [1] {ECO:0000313|EMBL:EJB42311.1, ECO:0000313|Proteomes:UP000003633} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hp A-4 {ECO:0000313|EMBL:EJB42311.1, RC ECO:0000313|Proteomes:UP000003633}; RX PubMed=23661595; DOI=10.1111/2049-632X.12045; RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M., RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K., RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.; RT "Genome sequences of 65 Helicobacter pylori strains isolated from RT asymptomatic individuals and patients with gastric cancer, peptic ulcer RT disease, or gastritis."; RL Pathog. Dis. 68:39-43(2013). CC -!- FUNCTION: Functions as a peptidoglycan terminase that cleaves nascent CC peptidoglycan strands endolytically to terminate their elongation. CC {ECO:0000256|HAMAP-Rule:MF_02065}. CC -!- SIMILARITY: Belongs to the transglycosylase MltG family. CC {ECO:0000256|HAMAP-Rule:MF_02065}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EJB42311.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AKOA01000004; EJB42311.1; -; Genomic_DNA. DR AlphaFoldDB; I9R6Y0; -. DR PATRIC; fig|992032.3.peg.772; -. DR Proteomes; UP000003633; Unassembled WGS sequence. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0008932; F:lytic endotransglycosylase activity; IEA:UniProtKB-UniRule. DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule. DR CDD; cd08010; MltG_like; 1. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1. DR HAMAP; MF_02065; MltG; 1. DR InterPro; IPR003770; MLTG-like. DR NCBIfam; TIGR00247; endolytic transglycosylase MltG; 1. DR PANTHER; PTHR30518:SF2; ENDOLYTIC MUREIN TRANSGLYCOSYLASE; 1. DR PANTHER; PTHR30518; UNCHARACTERIZED; 1. DR Pfam; PF02618; YceG; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP- KW Rule:MF_02065}; KW Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316, KW ECO:0000256|HAMAP-Rule:MF_02065}; KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_02065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02065}; KW Transferase {ECO:0000313|EMBL:EJB42311.1}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP- KW Rule:MF_02065}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP- KW Rule:MF_02065}. FT SITE 172 FT /note="Important for catalytic activity" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02065" SQ SEQUENCE 287 AA; 32580 MW; F26BC765A10CEEF8 CRC64; MVVVPQGSLK KVFFSLKEQG VDINALDLLL LRLMGMPKKG YIDMGDGALR KGDFLVRLIK AKAAQKSATL IPGETRYFFT QILSETYQLG VGDLNEAYES IAPRLNGSVI EDGVIWPDTY HLPLGEDAFK IMQALIGQSM KKHEALSKQW LGYYHKEEWF EKIILASIVQ KEAANIEEMP LIASVIFNRL KKGMPLQMDG ALNYQEFSHA KVTKERIKTD NTPYNTYKFK GLPKNPVGSV SLEAIRAVVF PKKTNFLYFV KMPDKKHAFS TTYKEHLKNI NLSNNHF //