ID I6TRR8_HUMAN Unreviewed; 979 AA. AC I6TRR8; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 28-FEB-2018, entry version 33. DE SubName: Full=SND1-BRAF fusion {ECO:0000313|EMBL:AFN01665.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AFN01665.1}; RN [1] {ECO:0000313|EMBL:AFN01665.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=22745804; DOI=10.1371/journal.pone.0039653; RA Lee N.V., Lira M.E., Pavlicek A., Ye J., Buckman D., Bagrodia S., RA Srinivasa S.P., Zhao Y., Aparicio S., Rejto P.A., Christensen J.G., RA Ching K.A.; RT "A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF- RT 04217903 in GTL16 Cells though MAPK Activation."; RL PLoS ONE 7:e39653-e39653(2012). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JX013981; AFN01665.1; -; mRNA. DR ProteinModelPortal; I6TRR8; -. DR PeptideAtlas; I6TRR8; -. DR eggNOG; KOG2039; Eukaryota. DR eggNOG; COG1525; LUCA. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004518; F:nuclease activity; IEA:InterPro. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro. DR Gene3D; 2.40.50.90; -; 4. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR InterPro; IPR035437; SNase_OB-fold_sf. DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold. DR InterPro; IPR002071; Thermonucl_AS. DR Pfam; PF07714; Pkinase_Tyr; 1. DR Pfam; PF00565; SNase; 3. DR SMART; SM00220; S_TKc; 1. DR SMART; SM00318; SNc; 4. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. DR PROSITE; PS01284; TNASE_2; 1. DR PROSITE; PS50830; TNASE_3; 3. PE 2: Evidence at transcript level; FT DOMAIN 18 166 TNase-like. {ECO:0000259|PROSITE: FT PS50830}. FT DOMAIN 193 328 TNase-like. {ECO:0000259|PROSITE: FT PS50830}. FT DOMAIN 341 496 TNase-like. {ECO:0000259|PROSITE: FT PS50830}. FT DOMAIN 670 930 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. SQ SEQUENCE 979 AA; 109147 MW; 8B4B073875C717F1 CRC64; MASSAQSGGS SGGPAVPTVQ RGIIKMVLSG CAIIVRGQPR GGPPPERQIN LSNIRAGNLA RRAAATQPDA KDTPDEPWAF PAREFLRKKL IGKEVCFTIE NKTPQGREYG MIYLGKDTNG ENIAESLVAE GLATRREGMR ANNPEQNRLS ECEEQAKAAK KGMWSEGNGS HTIRDLKYTI ENPRHFVDSH HQKPVNAIIE HVRDGSVVRA LLLPDYYLVT VMLSGIKCPT FRREADGSET PEPFAAEAKF FTESRLLQRD VQIILESCHN QNILGTILHP NGNITELLLK EGFARCVDWS IAVYTRGAEK LRAAERFAKE RRLRIWRDYV APTANLDQKD KQFVAKVMQV LNADAIVVKL NSGDYKTIHL SSIRPPRLEG ENTQDKNKKL RPLYDIPYMF EAREFLRKKL IGKKVNVTVD YIRPASPATE TVPAFSERTC ATVTIGGINI AEALVSKGLA TVIRYRQDDD QRSSHYDELL AAEARAIKNG KGLHSKKEVP IHRVADISGD TQKAKQFLPF LQRAGRSEAV VEYVFSGSRL KLYLPKETCL ITFLLAGIEC PRGARNLPGL VQEGEPFSEE ATLFTKELVL QREDLIRDQG FRGDGGSTTG LSATPPASLP GSLTNVKALQ KSPGPQRERK SSSSSEDRNR MKTLGRRDSS DDWEIPDGQI TVGQRIGSGS FGTVYKGKWH GDVAVKMLNV TAPTPQQLQA FKNEVGVLRK TRHVNILLFM GYSTKPQLAI VTQWCEGSSL YHHLHIIETK FEMIKLIDIA RQTAQGMDYL HAKSIIHRDL KSNNIFLHED LTVKIGDFGL ATVKSRWSGS HQFEQLSGSI LWMAPEVIRM QDKNPYSFQS DVYAFGIVLY ELMTGQLPYS NINNRDQIIF MVGRGYLSPD LSKVRSNCPK AMKRLMAECL KKKRDERPLF PQILASIELL ARSLPKIHRS ASEPSLNRAG FQTEDFSLYA CASPKTPIQA GGYGAFPVH //