ID I6TF46_9NEOP Unreviewed; 582 AA. AC I6TF46; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 18-JAN-2017, entry version 26. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5 {ECO:0000256|SAAS:SAAS00061106}; DE EC=1.6.5.3 {ECO:0000256|SAAS:SAAS00061108}; GN Name=ND5 {ECO:0000313|EMBL:AFM95199.1}; OS Actias selene (Indian moon moth). OG Mitochondrion {ECO:0000313|EMBL:AFM95199.1}. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; OC Bombycoidea; Saturniidae; Saturniinae; Saturniini; Actias. OX NCBI_TaxID=37776 {ECO:0000313|EMBL:AFM95199.1}; RN [1] {ECO:0000313|EMBL:AFM95199.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HF {ECO:0000313|EMBL:AFM95199.1}; RX PubMed=22688122; DOI=10.1016/j.gene.2012.06.003; RA Liu Q.N., Zhu B.J., Dai L.S., Wei G.Q., Liu C.L.; RT "The complete mitochondrial genome of the wild silkworm moth, Actias RT selene."; RL Gene 505:291-299(2012). RN [2] {ECO:0000313|EMBL:AFM95199.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HF {ECO:0000313|EMBL:AFM95199.1}; RA Liu C., Liu Q., Zhu B.; RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|SAAS:SAAS00061107}. CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + CC ubiquinol + 4 H(+)(Out). {ECO:0000256|SAAS:SAAS00061104}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|SAAS:SAAS00061113}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00061113}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JX186589; AFM95199.1; -; Genomic_DNA. DR RefSeq; YP_006504059.1; NC_018133.1. DR GeneID; 13230631; -. DR CTD; 4540; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR InterPro; IPR010934; NADH_DH_su5_C. DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr. DR InterPro; IPR001750; ND/Mrp_mem. DR Pfam; PF06455; NADH5_C; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01435; NPOXDRDTASE5. PE 4: Predicted; KW Electron transport {ECO:0000256|SAAS:SAAS00061110}; KW Membrane {ECO:0000256|SAAS:SAAS00448218, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|SAAS:SAAS00448066, KW ECO:0000313|EMBL:AFM95199.1}; KW Mitochondrion inner membrane {ECO:0000256|SAAS:SAAS00061114}; KW NAD {ECO:0000256|SAAS:SAAS00061109}; KW Oxidoreductase {ECO:0000256|SAAS:SAAS00061111}; KW Respiratory chain {ECO:0000256|SAAS:SAAS00061105}; KW Transmembrane {ECO:0000256|SAAS:SAAS00061112, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00061103, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00061102}; KW Ubiquinone {ECO:0000256|SAAS:SAAS00061120}. FT TRANSMEM 7 32 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 62 79 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 91 108 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 154 174 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 186 204 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 210 234 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 246 264 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 307 324 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 336 361 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 368 388 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 400 418 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 430 451 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 457 477 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 497 517 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 561 581 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 109 391 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. FT DOMAIN 396 577 NADH5_C. {ECO:0000259|Pfam:PF06455}. SQ SEQUENCE 582 AA; 67667 MW; 9BA80AF95CC0F731 CRC64; MFYKNYSICY ISFFFLFMYS MFNFMLMIYF IMNDLVYFFE WEIITLNSVS VVMSILLDWM SLLFMMFVCL ISSVVIYYSK SYMQSELNLD RFIILVLLFV FSMILLIISP NMVSILLGWD GLGLVSYCSV IYYQNLKSYN AGMLTALTNR IGDVFILMVI SWMLNYGSWD YISYLEFMKN DFMMEVIGVM IILAAMTKSA QIPFSSWLPA AMAAPTPVSA LVHSSTLVTV GVYLLNRFNM LLIDMFFFKI LLMLSILTMF MAGISANHEF DLKKIIALST LSQLGLMMSI LSMGFPNLAF FHLLTHAMFK ALLFMCAGVI IHMMNDIQDI RYMGGVSIYI PLTSLCLNIS NMALCGIPFL AGFYSKDLVL EMVSLSSLNF LVFFFYYIST GLTMFYTFRL LMYTMVMDFN LMVIYNLYDE DFIMLKSMMV LLFMSVISGS MLSWLIFSYP YMIYLPFNMK MMVIYVSLIG GILGYLVSNM KVYSVNKFLM TYSLSNFFCL MWFMPNLSTY GVTYYFLNLG QNLMKNIDLG WSELYSGQGM VNILKNNSIF YNIFQSNNMK IYLFSFVLWL FIMLMMITMI IY //