ID I6TF46_9NEOP Unreviewed; 582 AA. AC I6TF46; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 01-APR-2015, entry version 14. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5 {ECO:0000256|RuleBase:RU003404, ECO:0000256|SAAS:SAAS00061106}; DE EC=1.6.5.3 {ECO:0000256|RuleBase:RU003404, ECO:0000256|SAAS:SAAS00061108}; GN Name=ND5 {ECO:0000313|EMBL:AFM95199.1}; OS Actias selene (Indian moon moth). OG Mitochondrion {ECO:0000313|EMBL:AFM95199.1}. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; OC Bombycoidea; Saturniidae; Saturniinae; Saturniini; Actias. OX NCBI_TaxID=37776 {ECO:0000313|EMBL:AFM95199.1}; RN [1] {ECO:0000313|EMBL:AFM95199.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HF {ECO:0000313|EMBL:AFM95199.1}; RX PubMed=22688122; DOI=10.1016/j.gene.2012.06.003; RA Liu Q.N., Zhu B.J., Dai L.S., Wei G.Q., Liu C.L.; RT "The complete mitochondrial genome of the wild silkworm moth, Actias RT selene."; RL Gene 505:291-299(2012). RN [2] {ECO:0000313|EMBL:AFM95199.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HF {ECO:0000313|EMBL:AFM95199.1}; RA Liu C., Liu Q., Zhu B.; RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|SAAS:SAAS00061107}. CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + CC ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003404, CC ECO:0000256|SAAS:SAAS00061104}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU003404, ECO:0000256|SAAS:SAAS00061113}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU003404, CC ECO:0000256|SAAS:SAAS00061113}. CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. CC {ECO:0000256|RuleBase:RU003404}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JX186589; AFM95199.1; -; Genomic_DNA. DR RefSeq; YP_006504059.1; NC_018133.1. DR GeneID; 13230631; -. DR CTD; 4540; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR InterPro; IPR001516; H_transport_N. DR InterPro; IPR010934; NADH_DH_su5_C. DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr. DR InterPro; IPR001750; ND/Mrp_mem. DR Pfam; PF06455; NADH5_C; 1. DR Pfam; PF00361; Oxidored_q1; 1. DR Pfam; PF00662; Oxidored_q1_N; 1. DR PRINTS; PR01435; NPOXDRDTASE5. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|SAAS:SAAS00061110}; KW Membrane {ECO:0000256|SAAS:SAAS00061101}; KW Mitochondrion {ECO:0000256|RuleBase:RU000318, KW ECO:0000256|RuleBase:RU003404}; KW Mitochondrion inner membrane {ECO:0000256|SAAS:SAAS00061114}; KW NAD {ECO:0000256|RuleBase:RU000317, ECO:0000256|SAAS:SAAS00061109}; KW Oxidoreductase {ECO:0000256|RuleBase:RU000317, KW ECO:0000256|SAAS:SAAS00029640}; KW Respiratory chain {ECO:0000256|SAAS:SAAS00061105}; KW Transmembrane {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00061112}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00061103}; KW Transport {ECO:0000256|SAAS:SAAS00061102}; KW Ubiquinone {ECO:0000256|RuleBase:RU000318, KW ECO:0000256|RuleBase:RU003404}. SQ SEQUENCE 582 AA; 67667 MW; 9BA80AF95CC0F731 CRC64; MFYKNYSICY ISFFFLFMYS MFNFMLMIYF IMNDLVYFFE WEIITLNSVS VVMSILLDWM SLLFMMFVCL ISSVVIYYSK SYMQSELNLD RFIILVLLFV FSMILLIISP NMVSILLGWD GLGLVSYCSV IYYQNLKSYN AGMLTALTNR IGDVFILMVI SWMLNYGSWD YISYLEFMKN DFMMEVIGVM IILAAMTKSA QIPFSSWLPA AMAAPTPVSA LVHSSTLVTV GVYLLNRFNM LLIDMFFFKI LLMLSILTMF MAGISANHEF DLKKIIALST LSQLGLMMSI LSMGFPNLAF FHLLTHAMFK ALLFMCAGVI IHMMNDIQDI RYMGGVSIYI PLTSLCLNIS NMALCGIPFL AGFYSKDLVL EMVSLSSLNF LVFFFYYIST GLTMFYTFRL LMYTMVMDFN LMVIYNLYDE DFIMLKSMMV LLFMSVISGS MLSWLIFSYP YMIYLPFNMK MMVIYVSLIG GILGYLVSNM KVYSVNKFLM TYSLSNFFCL MWFMPNLSTY GVTYYFLNLG QNLMKNIDLG WSELYSGQGM VNILKNNSIF YNIFQSNNMK IYLFSFVLWL FIMLMMITMI IY //