ID I6QDQ4_9HIV1 Unreviewed; 90 AA. AC I6QDQ4; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 02-JUN-2021, entry version 29. DE RecName: Full=Protein Rev {ECO:0000256|ARBA:ARBA00020269, ECO:0000256|RuleBase:RU364044}; DE AltName: Full=Regulator of expression of viral proteins {ECO:0000256|ARBA:ARBA00017910, ECO:0000256|RuleBase:RU364044}; DE Flags: Fragment; GN Name=rev {ECO:0000256|RuleBase:RU364044, ECO:0000313|EMBL:AFK88280.1}; OS Human immunodeficiency virus 1. OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AFK88280.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AFK88280.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CH58wk4.3B3 {ECO:0000313|EMBL:AFK88280.1}; RX PubMed=22693447; DOI=10.1371/journal.ppat.1002721; RA Bar K.J., Tsao C.Y., Iyer S.S., Decker J.M., Yang Y., Bonsignori M., RA Chen X., Hwang K.K., Montefiori D.C., Liao H.X., Hraber P., Fischer W., RA Li H., Wang S., Sterrett S., Keele B.F., Ganusov V.V., Perelson A.S., RA Korber B.T., Georgiev I., McLellan J.S., Pavlicek J.W., Gao F., RA Haynes B.F., Hahn B.H., Kwong P.D., Shaw G.M.; RT "Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and RT Select for Virus Escape."; RL PLoS Pathog. 8:E1002721-E1002721(2012). CC -!- FUNCTION: Escorts unspliced or incompletely spliced viral pre-mRNAs CC (late transcripts) out of the nucleus of infected cells. These pre- CC mRNAs carry a recognition sequence called Rev responsive element (RRE) CC located in the env gene, that is not present in fully spliced viral CC mRNAs (early transcripts). This function is essential since most viral CC proteins are translated from unspliced or partially spliced pre-mRNAs CC which cannot exit the nucleus by the pathway used by fully processed CC cellular mRNAs. {ECO:0000256|RuleBase:RU364044}. CC -!- SUBUNIT: Homomultimer; when bound to the RRE. Multimeric assembly is CC essential for activity. {ECO:0000256|RuleBase:RU364044}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000256|RuleBase:RU364044}. CC Host nucleus, host nucleolus {ECO:0000256|ARBA:ARBA00004307, CC ECO:0000256|RuleBase:RU364044}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ957745; AFK88280.1; -; Genomic_RNA. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. DR InterPro; IPR000625; REV_protein. DR Pfam; PF00424; REV; 1. PE 4: Predicted; KW Host cytoplasm {ECO:0000256|RuleBase:RU364044}; KW Host nucleus {ECO:0000256|RuleBase:RU364044}; KW mRNA transport {ECO:0000256|ARBA:ARBA00022816, KW ECO:0000256|RuleBase:RU364044}; KW RNA-binding {ECO:0000256|RuleBase:RU364044}; KW Transport {ECO:0000256|RuleBase:RU364044}. FT REGION 1..22 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 43..90 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 59..75 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AFK88280.1" SQ SEQUENCE 90 AA; 9975 MW; 0205AEE207F29122 CRC64; PPPSSEGTRQ ARRNRRRRWR ERQRQIQRIS GWILSTYLGR SAEPVPLPLP PLERLTLGSN EDCGTSGSQG VGSPQVLVES PAVLESGTKE //